Science 4 January 1991: Vol. 251. no. 4989, pp. 72 - 75 DOI: 10.1126/science.1846048

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Articles

Drug-sensitive FGFR2 mutations in endometrial carcinoma.

A. Dutt, H. B. Salvesen, T.-H. Chen, A. H. Ramos, R. C. Onofrio, C. Hatton, R. Nicoletti, W. Winckler, R. Grewal, M. Hanna, et al. (2008)
PNAS 105, 8713-8717
 |  Abstract »  |  Full Text »  |  PDF »

Specific Heparan Sulfate Structures Modulate FGF10-mediated Submandibular Gland Epithelial Morphogenesis and Differentiation.

V. N. Patel, K. M. Likar, S. Zisman-Rozen, S. N. Cowherd, K. S. Lassiter, I. Sher, E. A. Yates, J. E. Turnbull, D. Ron, and M. P. Hoffman (2008)
J. Biol. Chem. 283, 9308-9317
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Fibroblast Growth Factor Receptor 2 Isoform Switching in Mammary Oncogenesis.

J. Y. Cha, Q. T. Lambert, G. W. Reuther, and C. J. Der (2008)
Mol. Cancer Res. 6, 435-445
 |  Abstract »  |  Full Text »  |  PDF »

Compensatory paracrine mechanisms that define the urothelial response to injury in partial bladder outlet obstruction.

T. S. Lendvay, R. Sweet, C.-H. Han, T. Soygur, J.-F. Cheng, J. C. Plaire, J. S. Charleston, L. B. Charleston, S. Bagai, K. Cochrane, et al. (2007)
Am J Physiol Renal Physiol 293, F1147-F1156
 |  Abstract »  |  Full Text »  |  PDF »

KGF promotes integrin {alpha}5 expression through CCAAT/enhancer-binding protein-beta.

P. Koria and S. T. Andreadis (2007)
Am J Physiol Cell Physiol 293, C1020-C1031
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte Growth Factor/Fibroblast Growth Factor-7-regulated Cell Migration and Invasion through Activation of NF-{kappa}B Transcription Factors.

J. Niu, Z. Chang, B. Peng, Q. Xia, W. Lu, P. Huang, M.-S. Tsao, and P. J. Chiao (2007)
J. Biol. Chem. 282, 6001-6011
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors..

P. W. Finch and J. S. Rubin (2006)
J Natl Cancer Inst 98, 812-824
 |  Abstract »  |  Full Text »  |  PDF »

Biomimetic Delivery of Keratinocyte Growth Factor upon Cellular Demand for Accelerated Wound Healing in Vitro and in Vivo.

D. J. Geer, D. D. Swartz, and S. T. Andreadis (2005)
Am. J. Pathol. 167, 1575-1586
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Epithelial Cells by Keratincoyte Growth Factor Signaling.

P. Ray (2005)
Proceedings of the ATS 2, 221-225
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of primordial follicle assembly and development.

M. K. Skinner (2005)
Hum. Reprod. Update 11, 461-471
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.

K. Ulrich, M. Stern, M. E. Goddard, J. Williams, J. Zhu, A. Dewar, H. A. Painter, P. K. Jeffery, D. R. Gill, S. C. Hyde, et al. (2005)
Am J Physiol Lung Cell Mol Physiol 288, L1179-L1192
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.

O. A. Ibrahimi, F. Zhang, A. V. Eliseenkova, N. Itoh, R. J. Linhardt, and M. Mohammadi (2004)
Hum. Mol. Genet. 13, 2313-2324
 |  Abstract »  |  Full Text »  |  PDF »

Activated Hepatic Stellate Cells Express Keratinocyte Growth Factor in Chronic Liver Disease.

H. Steiling, M. Muhlbauer, F. Bataille, J. Scholmerich, S. Werner, and C. Hellerbrand (2004)
Am. J. Pathol. 165, 1233-1241
 |  Abstract »  |  Full Text »  |  PDF »

Nucleotide Exchange Factor ECT2 Interacts with the Polarity Protein Complex Par6/Par3/Protein Kinase C{zeta} (PKC{zeta}) and Regulates PKC{zeta} Activity.

X.-F. Liu, H. Ishida, R. Raziuddin, and T. Miki (2004)
Mol. Cell. Biol. 24, 6665-6675
 |  Abstract »  |  Full Text »  |  PDF »

Expression analysis of an FGFR2 IIIc 5' splice site mutation (1084+3A->G).

R Kan, S R F Twigg, J Berg, L Wang, F Jin, and A O M Wilkie (2004)
J. Med. Genet. 41, e108
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Deregulation and Mislocalization of the Cytokinesis Regulator ECT2 Activate the Rho Signaling Pathways Leading to Malignant Transformation.

S.'i. Saito, X.-F. Liu, K. Kamijo, R. Raziuddin, T. Tatsumoto, I. Okamoto, X. Chen, C.-C. Lee, M. V. Lorenzi, N. Ohara, et al. (2004)
J. Biol. Chem. 279, 7169-7179
 |  Abstract »  |  Full Text »  |  PDF »

A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells.

M. Platica, E. Ivan, J. F. Holland, A. Ionescu, S. Chen, J. Mandeli, P. D. Unger, and O. Platica (2004)
PNAS 101, 1560-1565
 |  Abstract »  |  Full Text »  |  PDF »

Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity.

E. Preger, I. Ziv, A. Shabtay, I. Sher, M. Tsang, I. B. Dawid, Y. Altuvia, and D. Ron (2004)
PNAS 101, 1229-1234
 |  Abstract »  |  Full Text »  |  PDF »

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay.

E. J. WAGNER, M. L. CURTIS, N. D. ROBSON, A. P. BARANIAK, P. S. EIS, and M. A. GARCIA-BLANCO (2003)
RNA 9, 1552-1561
 |  Abstract »  |  Full Text »  |  PDF »

BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.

P. T. Tsai, R. A. Lee, and H. Wu (2003)
Blood 102, 3947-3953
 |  Abstract »  |  Full Text »  |  PDF »

Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia.

P. Ray, Y. Devaux, D. B. Stolz, M. Yarlagadda, S. C. Watkins, Y. Lu, L. Chen, X.-f. Yang, and A. Ray (2003)
PNAS 100, 6098-6103
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Mitogen-Activated Protein Kinase Pathway by Keratinocyte Growth Factor or Fibroblast Growth Factor-10 Promotes Cell Proliferation in Human Endometrial Carcinoma Cells.

F. Taniguchi, T. Harada, Y. Sakamoto, N. Yamauchi, S. Yoshida, T. Iwabe, and N. Terakawa (2003)
J. Clin. Endocrinol. Metab. 88, 773-780
 |  Abstract »  |  Full Text »  |  PDF »

A Non-sequence-specific Double-stranded RNA Structural Element Regulates Splicing of Two Mutually Exclusive Exons of Fibroblast Growth Factor Receptor 2 (FGFR2).

S. J. Muh, R. H. Hovhannisyan, and R. P. Carstens (2002)
J. Biol. Chem. 277, 50143-50154
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Keratinocyte Growth Factor 1 Expression by Lipopolysaccharide Is Regulated by CD-14 and Toll-Like Receptors 2 and 4.

E. E. Putnins, A.-R. Sanaie, Q. Wu, and J. D. Firth (2002)
Infect. Immun. 70, 6541-6548
 |  Abstract »  |  Full Text »  |  PDF »

Dermatan Sulfate Binds and Potentiates Activity of Keratinocyte Growth Factor (FGF-7).

J. M. Trowbridge, J. A. Rudisill, D. Ron, and R. L. Gallo (2002)
J. Biol. Chem. 277, 42815-42820
 |  Abstract »  |  Full Text »  |  PDF »

Protection of the intestinal mucosa by intraepithelial gamma delta T cells.

Y. Chen, K. Chou, E. Fuchs, W. L. Havran, and R. Boismenu (2002)
PNAS 99, 14338-14343
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.

S. Rossi, B. R. Blazar, C. L. Farrell, D. M. Danilenko, D. L. Lacey, K. I. Weinberg, W. Krenger, and G. A. Hollander (2002)
Blood 100, 682-691
 |  Abstract »  |  Full Text »  |  PDF »

rHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease.

F. R. Byrne, C. L. Farrell, R. Aranda, K. L. Rex, S. Scully, H. L. Brown, S. A. Flores, L. H. Gu, D. M. Danilenko, D. L. Lacey, et al. (2002)
Am J Physiol Gastrointest Liver Physiol 282, G690-G701
 |  Abstract »  |  Full Text »  |  PDF »

Laser Capture Microdissection and Real-Time Reverse Transcriptase/ Polymerase Chain Reaction of Bronchiolar Epithelium after Bleomycin.

T. Betsuyaku, G. L. Griffin, M. A. Watson, and R. M. Senior (2001)
Am. J. Respir. Cell Mol. Biol. 25, 278-284
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system.

S. T. ANDREADIS, K. E. HAMOEN, M. L. YARMUSH, and J. R. MORGAN (2001)
FASEB J 15, 898-906
 |  Abstract »  |  Full Text »  |  PDF »

Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.

K. Yu, A. B. Herr, G. Waksman, and D. M. Ornitz (2000)
PNAS 97, 14536-14541
 |  Abstract »  |  Full Text »  |  PDF »

Up-Modulation of the Expression of Functional Keratinocyte Growth Factor Receptors Induced by High Cell Density in the Human Keratinocyte HaCaT Cell Line.

A. Capone, V. Visco, F. Belleudi, C. Marchese, G. Cardinali, M. Bellocci, M. Picardo, L. Frati, and M. R. Torrisi (2000)
Cell Growth Differ. 11, 607-614
 |  Abstract »  |  Full Text »

Keratinocyte Growth Factor: Expression by Endometrial Epithelia of the Porcine Uterus.

H. Ka, T. E. Spencer, G. A. Johnson, and F. W. Bazer (2000)
Biol Reprod 62, 1772-1778
 |  Abstract »  |  Full Text »

Tumor Necrosis Factor-alpha -converting Enzyme Is Required for Cleavage of erbB4/HER4.

C. Rio, J. D. Buxbaum, J. J. Peschon, and G. Corfas (2000)
J. Biol. Chem. 275, 10379-10387
 |  Abstract »  |  Full Text »  |  PDF »

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway.

S. Murakami, M. Kan, W. L. McKeehan, and B. de Crombrugghe (2000)
PNAS 97, 1113-1118
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Keratinocyte Growth Factor in the Endometrium of Rhesus Macaques during the Luteal-Follicular Transition.

O. D. Slayden, J. S. Rubin, D. L. Lacey, and R. M. Brenner (2000)
J. Clin. Endocrinol. Metab. 85, 275-285
 |  Abstract »  |  Full Text »

Similarities and Differences between the Effects of Heparin and Glypican-1 on the Bioactivity of Acidic Fibroblast Growth Factor and the Keratinocyte Growth Factor.

B. Berman, O. Ostrovsky, M. Shlissel, T. Lang, D. Regan, I. Vlodavsky, R. Ishai-Michaeli, and D. Ron (1999)
J. Biol. Chem. 274, 36132-36138
 |  Abstract »  |  Full Text »  |  PDF »

Mapping Ligand Binding Domains in Chimeric Fibroblast Growth Factor Receptor Molecules. MULTIPLE REGIONS DETERMINE LIGAND BINDING SPECIFICITY.

A. Chellaiah, W. Yuan, M. Chellaiah, and D. M. Ornitz (1999)
J. Biol. Chem. 274, 34785-34794
 |  Abstract »  |  Full Text »  |  PDF »

Mutations Uncouple Human Fibroblast Growth Factor (FGF)-7 Biological Activity and Receptor Binding and Support Broad Specificity in the Secondary Receptor Binding Site of FGFs.

I. Sher, A. Weizman, S. Lubinsky-Mink, T. Lang, N. Adir, D. Schomburg, and D. Ron (1999)
J. Biol. Chem. 274, 35016-35022
 |  Abstract »  |  Full Text »  |  PDF »

Human ECT2 Is an Exchange Factor for Rho GTPases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis.

T. Tatsumoto, X. Xie, R. Blumenthal, I. Okamoto, and T. Miki (1999)
J. Cell Biol. 147, 921-928
 |  Abstract »  |  Full Text »  |  PDF »

The Acidic Domain and First Immunoglobulin-Like Loop of Fibroblast Growth Factor Receptor 2 Modulate Downstream Signaling through Glycosaminoglycan Modification.

K. Sakaguchi, M. V. Lorenzi, D. P. Bottaro, and T. Miki (1999)
Mol. Cell. Biol. 19, 6754-6764
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte growth factor stimulates bronchial epithelial cell proliferation in vitro and in vivo.

P. H. Michelson, M. Tigue, R. J. Panos, and P. H. S. Sporn (1999)
Am J Physiol Lung Cell Mol Physiol 277, L737-L742
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Characterization of a Mouse Homolog of Bacterial ClpX, a Novel Mammalian Class II Member of the Hsp100/Clp Chaperone Family.

S. Santagata, D. Bhattacharyya, F.-H. Wang, N. Singha, A. Hodtsev, and E. Spanopoulou (1999)
J. Biol. Chem. 274, 16311-16319
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte Growth Factor Protects Alveolar Epithelium and Endothelium from Oxygen-Induced Injury in Mice.

C. Barazzone, Y. R. Donati, A. F. Rochat, C. Vesin, C.-D. Kan, J. C. Pache, and P. F. Piguet (1999)
Am. J. Pathol. 154, 1479-1487
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and characterization of a naturally occurring soluble form of TGF-beta type I receptor.

M. E. Choi (1999)
Am J Physiol Renal Physiol 276, F88-F95
 |  Abstract »  |  Full Text »  |  PDF »

Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features.

C. Lopez-Otin and E. P. Diamandis (1998)
Endocr. Rev. 19, 365-396
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue.

A. De Bellis, C. Crescioli, C. Grappone, S. Milani, P. Ghiandi, G. Forti, and M. Serio (1998)
J. Clin. Endocrinol. Metab. 83, 2186-2191
 |  Abstract »  |  Full Text »

Mammogenic Hormones Differentially Modulate Keratinocyte Growth Factor (KGF)-Induced Proliferation and KGF Receptor Expression in Cultured Mouse Mammary Gland Epithelium.

V. K. Pedchenko and W. T. Imagawa (1998)
Endocrinology 139, 2519-2526
 |  Abstract »  |  Full Text »  |  PDF »

An Intronic Sequence Element Mediates Both Activation and Repression of Rat Fibroblast Growth Factor Receptor 2 Pre-mRNA Splicing.

R. P. Carstens, W. L. McKeehan, and M. A. Garcia-Blanco (1998)
Mol. Cell. Biol. 18, 2205-2217
 |  Abstract »  |  Full Text »

Receptor-mediated endocytosis of keratinocyte growth factor.

C Marchese, P Mancini, F Belleudi, A Felici, R Gradini, T Sansolini, L Frati, and M. Torrisi (1998)
J. Cell Sci. 111, 3517-3527
 |  Abstract »  |  PDF »

A Novel Juxtamembrane Domain Isoform of HER4/ErbB4. ISOFORM-SPECIFIC TISSUE DISTRIBUTION AND DIFFERENTIAL PROCESSING IN RESPONSE TO PHORBOL ESTER.

K. Elenius, G. Corfas, S. Paul, C. J. Choi, C. Rio, G. D. Plowman, and M. Klagsbrun (1997)
J. Biol. Chem. 272, 26761-26768
 |  Abstract »  |  Full Text »  |  PDF »

A Homeo-interaction Sequence in the Ectodomain of the Fibroblast Growth Factor Receptor.

F. Wang, M. Kan, K. McKeehan, J.-H. Jang, S. Feng, and W. L. McKeehan (1997)
J. Biol. Chem. 272, 23887-23895
 |  Abstract »  |  Full Text »  |  PDF »

Cell Type-specific Inhibition of Keratinocyte Collagenase-1 Expression by Basic Fibroblast Growth Factor and Keratinocyte Growth Factor. A COMMON RECEPTOR PATHWAY.

B. K. Pilcher, J. Gaither-Ganim, W. C. Parks, and H. G. Welgus (1997)
J. Biol. Chem. 272, 18147-18154
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a 79-kDa Heparin-binding Fibroblast Growth Factor (FGF) Receptor in Rat Hepatocytes and Its Correlation with the Different Growth Responses to FGF-1 between Hepatocyte Subpopulations.

T. Tanahashi, M. Suzuki, T. Imamura, and Y. Mitsui (1996)
J. Biol. Chem. 271, 8221-8227
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte Growth Factor Inhibits Cross-linked Envelope Formation and Nucleosomal Fragmentation in Cultured Human Keratinocytes.

M. D. Hines and B. L. Allen-Hoffmann (1996)
J. Biol. Chem. 271, 6245-6251
 |  Abstract »  |  Full Text »  |  PDF »

Copper and Calcium Binding Motifs in the Extracellular Domains of Fibroblast Growth Factor Receptors.

G. Patstone and P. Maher (1996)
J. Biol. Chem. 271, 3343-3346
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte growth factor is required for hair development but not for wound healing..

L Guo, L Degenstein, and E Fuchs (1996)
Genes & Dev. 10, 165-175
 |  Abstract »  |  PDF »

Conservation of Ligand Specificity between the Mammalian and Amphibian Fibroblast Growth Factor Receptors.

K. M. Patrie, A. J. Kudla, B. B. Olwin, and I.-M. Chiu (1995)
J. Biol. Chem. 270, 29018-29024
 |  Abstract »  |  Full Text »  |  PDF »

Alternately Spliced NH[IMAGE]-terminal Immunoglobulin-like Loop I in the Ectodomain of the Fibroblast Growth Factor (FGF) Receptor 1 Lowers Affinity for both Heparin and FGF-1.

F. Wang, M. Kan, G. Yan, J. Xu, and W. L. McKeehan (1995)
J. Biol. Chem. 270, 10231-10235
 |  Abstract »  |  Full Text »  |  PDF »

Fibroblast Growth Factor (FGF) 3 from Xenopus laevis (XFGF3) Binds with High Affinity to FGF Receptor 2.

M. Mathieu, P. Kiefer, I. Mason, and C. Dickson (1995)
J. Biol. Chem. 270, 6779-6787
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Scatter Factor/Hepatocyte Growth Factor Gene Promoter.

A. Plaschke-Schlütter, Jür. Behrens, E. Gherardi, and W. Birchmeier (1995)
J. Biol. Chem. 270, 830-836
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of epithelial cell growth by intraepithelial gamma delta T cells.

R Boismenu and W. Havran (1994)
Science 266, 1253-1255
 |  Abstract »  |  PDF »

Isolation and developmental expression of the amphibian homolog of the fibroblast growth factor receptor 3.

D. Shi, V Fromentoux, C Launay, M Umbhauer, and J. Boucaut (1994)
J. Cell Sci. 107, 417-425
 |  Abstract »  |  PDF »

Heterogeneity in the expression of fibroblast growth factor receptors during limb regeneration in newts (Notophthalmus viridescens).

M. Poulin, K. Patrie, M. Botelho, R. Tassava, and I. Chiu (1993)
Development 119, 353-361
 |  Abstract »  |  PDF »

Basic fibroblast growth factor (bFGF) acts intracellularly to cause the transdifferentiation of avian neural crest-derived Schwann cell precursors into melanocytes.

L Sherman, K. Stocker, R Morrison, and G Ciment (1993)
Development 118, 1313-1326
 |  Abstract »  |  PDF »

Amplification and cloning of sugarcane sucrose synthase cDNA by anchored PCR..

A S Kumar, P H Moore, and A Maretzki (1992)
Genome Res. 2, 70-75
 |  Abstract »  |  PDF »

Growth factors and cancer.

S. Aaronson (1991)
Science 254, 1146-1153
 |  Abstract »  |  PDF »

Identification of Residues Important Both for Primary Receptor Binding and Specificity in Fibroblast Growth Factor-7.

I. Sher, T. Lang, S. Lubinsky-Mink, J. Kuhn, N. Adir, S. Chatterjee, D. Schomburg, and D. Ron (2000)
J. Biol. Chem. 275, 34881-34886
 |  Abstract »  |  Full Text »  |  PDF »

Association of the Signaling Adaptor FRS2 with Fibroblast Growth Factor Receptor 1 (Fgfr1) Is Mediated by Alternative Splicing of the Juxtamembrane Domain.

H. R. Burgar, H. D. Burns, J. L. Elsden, M. D. Lalioti, and J. K. Heath (2002)
J. Biol. Chem. 277, 4018-4023
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of Heparin Saccharides on the Formation of Specific Fibroblast Growth Factor (FGF) and FGF Receptor Complexes.

O. Ostrovsky, B. Berman, J. Gallagher, B. Mulloy, D. G. Fernig, M. Delehedde, and D. Ron (2002)
J. Biol. Chem. 277, 2444-2453
 |  Abstract »  |  Full Text »  |  PDF »

Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis.

Y. Zhang, H. Wang, S. Toratani, J. D. Sato, M. Kan, W. L. McKeehan, and T. Okamoto (2001)
PNAS 98, 11336-11340
 |  Abstract »  |  Full Text »  |  PDF »

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