Science 4 January 1991: Vol. 251. no. 4989, pp. 70 - 72 DOI: 10.1126/science.1702555

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Articles

Induction of Exosome Release in Primary B Cells Stimulated via CD40 and the IL-4 Receptor.

S. C. Saunderson, P. C. Schuberth, A. C. Dunn, L. Miller, B. D. Hock, P. A. MacKay, N. Koch, R. W. Jack, and A. D. McLellan (2008)
J. Immunol. 180, 8146-8152
 |  Abstract »  |  Full Text »  |  PDF »

STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation.

S. A. Diehl, H. Schmidlin, M. Nagasawa, S. D. van Haren, M. J. Kwakkenbos, E. Yasuda, T. Beaumont, F. A. Scheeren, and H. Spits (2008)
J. Immunol. 180, 4805-4815
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Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4.

S. Willimott, M. Baou, S. Huf, S. Deaglio, and S. D. Wagner (2007)
Haematologica 92, 1359-1366
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CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation.

J. M. Carr, M. J. Carrasco, J. E. D. Thaventhiran, P. J. Bambrough, M. Kraman, A. D. Edwards, A. Al-Shamkhani, and D. T. Fearon (2006)
PNAS 103, 19454-19459
 |  Abstract »  |  Full Text »  |  PDF »

Agonistic Monoclonal Antibody Against CD40 Receptor Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis.

S. J. Schwulst, M. H. Grayson, P. J. DiPasco, C. G. Davis, T. S. Brahmbhatt, T. A. Ferguson, and R. S. Hotchkiss (2006)
J. Immunol. 177, 557-565
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Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus.

C. Mancao, M. Altmann, B. Jungnickel, and W. Hammerschmidt (2005)
Blood 106, 4339-4344
 |  Abstract »  |  Full Text »  |  PDF »

Reliability of Platelet-Derived Endothelial Cell Growth Factor as a Prognostic Factor for Oral and Oropharyngeal Carcinomas.

H. Tsuzuki, H. Sunaga, T. Ito, N. Narita, C. Sugimoto, and S. Fujieda (2005)
Arch Otolaryngol Head Neck Surg 131, 1071-1078
 |  Abstract »  |  Full Text »  |  PDF »

A Role for c-fos/Activator Protein 1 in B Lymphocyte Terminal Differentiation.

Y. Ohkubo, M. Arima, E. Arguni, S. Okada, K. Yamashita, S. Asari, S. Obata, A. Sakamoto, M. Hatano, J. O-Wang, et al. (2005)
J. Immunol. 174, 7703-7710
 |  Abstract »  |  Full Text »  |  PDF »

Regression of Epstein-Barr Virus-Induced B-Cell Transformation In Vitro Involves Virus-Specific CD8+ T Cells as the Principal Effectors and a Novel CD4+ T-Cell Reactivity.

N. H. Gudgeon, G. S. Taylor, H. M. Long, T. A. Haigh, and A. B. Rickinson (2005)
J. Virol. 79, 5477-5488
 |  Abstract »  |  Full Text »  |  PDF »

Tracking CD40 signaling during germinal center development.

K. Basso, U. Klein, H. Niu, G. A. Stolovitzky, Y. Tu, A. Califano, G. Cattoretti, and R. Dalla-Favera (2004)
Blood 104, 4088-4096
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Donor and Recipient CD40 Expression in Cardiac Allograft Rejection: Induction of Th1 Responses and Influence of Donor-Derived Dendritic Cells.

M. J. Nathan, J. E. Mold, S. C. Wood, K. Csencsits, G. Lu, E. J. Eichwald, and D. K. Bishop (2004)
J. Immunol. 172, 6626-6633
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr Virus Nuclear Antigen Leader Protein Induces Expression of Thymus- and Activation-Regulated Chemokine in B Cells.

M. Kanamori, S. Watanabe, R. Honma, M. Kuroda, S. Imai, K. Takada, N. Yamamoto, Y. Nishiyama, and Y. Kawaguchi (2004)
J. Virol. 78, 3984-3993
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation and differentiation in isogenic populations of peripheral B cells activated by Epstein-Barr virus or T cell-derived mitogens.

J. O'Nions and M. J. Allday (2004)
J. Gen. Virol. 85, 881-895
 |  Abstract »  |  Full Text »  |  PDF »

RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy.

C. M. Coughlin, B. A. Vance, S. A. Grupp, and R. H. Vonderheide (2004)
Blood 103, 2046-2054
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression.

S. Mouhamad, L. Besnault, M. T. Auffredou, C. Leprince, M. F. Bourgeade, G. Leca, and A. Vazquez (2004)
J. Immunol. 172, 2084-2091
 |  Abstract »  |  Full Text »  |  PDF »

Identification, Isolation, and Culture of HLA-A2-Specific B Lymphocytes Using MHC Class I Tetramers.

A. Mulder, C. Eijsink, M. J. Kardol, M. E. I. Franke-van Dijk, S. H. van der Burg, M. Kester, I. I. N. Doxiadis, and F. H. J. Claas (2003)
J. Immunol. 171, 6599-6603
 |  Abstract »  |  Full Text »  |  PDF »

CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses.

B. O. Lee, J. Moyron-Quiroz, J. Rangel-Moreno, K. L. Kusser, L. Hartson, F. Sprague, F. E. Lund, and T. D. Randall (2003)
J. Immunol. 171, 5707-5717
 |  Abstract »  |  Full Text »  |  PDF »

CD40 Stimulation of Human Peripheral B Lymphocytes: Distinct Response from Naive and Memory Cells.

J. F. Fecteau and S. Neron (2003)
J. Immunol. 171, 4621-4629
 |  Abstract »  |  Full Text »  |  PDF »

Membrane-anchored CD40 Is Processed by the Tumor Necrosis Factor-{alpha}-converting Enzyme: IMPLICATIONS FOR CD40 SIGNALING.

C. Contin, V. Pitard, T. Itai, S. Nagata, J.-F. Moreau, and J. Dechanet-Merville (2003)
J. Biol. Chem. 278, 32801-32809
 |  Abstract »  |  Full Text »  |  PDF »

Intravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG.

M. J. de Grandmont, C. Racine, A. Roy, R. Lemieux, and S. Neron (2003)
Blood 101, 3065-3073
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cell-Induced Differentiation of EBV-Transformed Lymphoblastoid Cells Is Associated with Diminished Recognition by EBV-Specific CD8+ Cytotoxic T Cells.

A. Khanolkar, Z. Fu, L. J. Underwood, K. L. Bondurant, R. Rochford, and M. J. Cannon (2003)
J. Immunol. 170, 3187-3194
 |  Abstract »  |  Full Text »  |  PDF »

CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays.

C.-M. Hogerkorp, S. Bilke, T. Breslin, S. Ingvarsson, and C. A. K. Borrebaeck (2003)
Blood 101, 2307-2313
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Pemphigus Phenotype by a Mouse Monoclonal Antibody Against the Amino-Terminal Adhesive Interface of Desmoglein 3.

K. Tsunoda, T. Ota, M. Aoki, T. Yamada, T. Nagai, T. Nakagawa, S. Koyasu, T. Nishikawa, and M. Amagai (2003)
J. Immunol. 170, 2170-2178
 |  Abstract »  |  Full Text »  |  PDF »

LMP-1's Transmembrane Domains Encode Multiple Functions Required for LMP-1's Efficient Signaling.

A. Kaykas, K. Worringer, and B. Sugden (2002)
J. Virol. 76, 11551-11560
 |  Abstract »  |  Full Text »  |  PDF »

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.

M. S. von Bergwelt-Baildon, R. H. Vonderheide, B. Maecker, N. Hirano, K. S. Anderson, M. O. Butler, Z. Xia, W. Y. Zeng, K. W. Wucherpfennig, L. M. Nadler, et al. (2002)
Blood 99, 3319-3325
 |  Abstract »  |  Full Text »  |  PDF »

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

F. Jundt, I. Anagnostopoulos, R. Forster, S. Mathas, H. Stein, and B. Dorken (2002)
Blood 99, 3398-3403
 |  Abstract »  |  Full Text »  |  PDF »

CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion.

N J Gallagher, A G Eliopoulos, A Agathangelo, J Oates, J Crocker, and L S Young (2002)
Mol. Pathol. 55, 110-120
 |  Abstract »  |  Full Text »  |  PDF »

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF-p53 signaling.

A. Shvarts, T. R. Brummelkamp, F. Scheeren, E. Koh, G. Q. Daley, H. Spits, and R. Bernards (2002)
Genes & Dev. 16, 681-686
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Human CD8 T Regulatory Cells by CD40 Ligand-activated Plasmacytoid Dendritic Cells.

M. Gilliet and Y.-J. Liu (2002)
J. Exp. Med. 195, 695-704
 |  Abstract »  |  Full Text »  |  PDF »

Opposing Effects of Anti-Activation-Inducible Lymphocyte- Immunomodulatory Molecule/Inducible Costimulator Antibody on the Development of Acute Versus Chronic Graft-Versus-Host Disease.

S.-h. Ogawa, G. Nagamatsu, M. Watanabe, S. Watanabe, T. Hayashi, S. Horita, K. Nitta, H. Nihei, K. Tezuka, and R. Abe (2001)
J. Immunol. 167, 5741-5748
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Study of Recombinant Human CD40 Ligand in Cancer Patients.

R. H. Vonderheide, J. P. Dutcher, J. E. Anderson, S. G. Eckhardt, K. F. Stephans, B. Razvillas, S. Garl, M. D. Butine, V. P. Perry, R. J. Armitage, et al. (2001)
J. Clin. Oncol. 19, 3280-3287
 |  Abstract »  |  Full Text »  |  PDF »

Is the 135S Poliovirus Particle an Intermediate during Cell Entry?.

Y. Huang, J. M. Hogle, and M. Chow (2000)
J. Virol. 74, 8757-8761
 |  Abstract »  |  Full Text »

Functional Analysis of the CD4+ T-Cell Response to Epstein-Barr Virus: T-Cell-Mediated Activation of Resting B Cells and Induction of Viral BZLF1 Expression.

Z. Fu and M. J. Cannon (2000)
J. Virol. 74, 6675-6679
 |  Abstract »  |  Full Text »

Regulation of CD30 Antigen Expression and Its Potential Significance for Human Disease.

M. E. Kadin (2000)
Am. J. Pathol. 156, 1479-1484
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Stromal Cell-Derived Factor-1 as a Chemoattractant for Follicular Center Lymphoma B Cells.

A. Corcione, L. Ottonello, G. Tortolina, P. Facchetti, I. Airoldi, R. Guglielmino, P. Dadati, M. Truini, S. Sozzani, F. Dallegri, et al. (2000)
J Natl Cancer Inst 92, 628-635
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of NF-{kappa}B Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells.

R. R. Furman, Z. Asgary, J. O. Mascarenhas, H.-C. Liou2, and E. J. Schattner (2000)
J. Immunol. 164, 2200-2206
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-Mediated Cytotoxicity of Chronic Lymphocytic Leukemia Cells.

D. J. Medina, W. Sheay, L. Goodell, P. Kidd, E. White, A. B. Rabson, and R. K. Strair (1999)
Blood 94, 3499-3508
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous Growth of Kaposi's Sarcoma Herpesvirus-Associated Infected Primary Effusion Lymphoma Cells.

K. D. Jones, Y. Aoki, Y. Chang, P. S. Moore, R. Yarchoan, and G. Tosato (1999)
Blood 94, 2871-2879
 |  Abstract »  |  Full Text »  |  PDF »

Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses.

J. Uchida, T. Yasui, Y. Takaoka-Shichijo, M. Muraoka, W. Kulwichit, N. Raab-Traub, and H. Kikutani (1999)
Science 286, 300-303
 |  Abstract »  |  Full Text »

CD40-Mediated Induction of CD4 and CXCR4 on B Lymphocytes Correlates with Restricted Susceptibility to Human Immunodeficiency Virus Type 1 Infection: Potential Role of B Lymphocytes as a Viral Reservoir.

S. Moir, R. Lapointe, A. Malaspina, M. Ostrowski, C. E. Cole, T.-W. Chun, J. Adelsberger, M. Baseler, P. Hwu, and A. S. Fauci (1999)
J. Virol. 73, 7972-7980
 |  Abstract »  |  Full Text »  |  PDF »

Surface Membrane-expressed CD40 Is Present on Tumor Cells from Squamous Cell Cancer of the Head and Neck in Vitro and in Vivo and Regulates Cell Growth in Tumor Cell Lines.

M. R. Posner, L. A. Cavacini, M. P. Upton, K. C. Tillman, E. R. Gornstein, and C. M. Norris Jr. (1999)
Clin. Cancer Res. 5, 2261-2270
 |  Abstract »  |  Full Text »  |  PDF »

CD40 signaling induces B cell responsiveness to multiple members of the {gamma} chain-common cytokine family.

P. Griebel, T. Beskorwayne, A. Van den Broeke, and G. Ferrari (1999)
Int. Immunol. 11, 1139-1147
 |  Abstract »  |  Full Text »  |  PDF »

Differential Responses to CD40 Ligation Among Burkitt Lymphoma Lines That Are Uniformly Responsive to Epstein-Barr Virus Latent Membrane Protein 1.

N. V. Henriquez, E. Floettmann, M. Salmon, M. Rowe, and A. B. Rickinson (1999)
J. Immunol. 162, 3298-3307
 |  Abstract »  |  Full Text »  |  PDF »

Mouse IL-13 Enhances Antibody Production In Vivo and Acts Directly on B Cells In Vitro to Increase Survival and Hence Antibody Production.

Y. H. Lai and T. R. Mosmann (1999)
J. Immunol. 162, 78-87
 |  Abstract »  |  Full Text »  |  PDF »

CD27/CD70 Interaction Augments IgE Secretion by Promoting the Differentiation of Memory B Cells into Plasma Cells.

H. Nagumo, K. Agematsu, K. Shinozaki, S. Hokibara, S. Ito, M. Takamoto, T. Nikaido, K. Yasui, Y. Uehara, A. Yachie, et al. (1998)
J. Immunol. 161, 6496-6502
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a Critical Role for IL-2 in CD40-Mediated Activation of Naive B Cells by Primary CD4 T Cells.

C. Johnson-Leger, J. R. Christenson, M. Holman, and G. G. B. Klaus (1998)
J. Immunol. 161, 4618-4626
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes.

B. Dubois, C. Massacrier, B. Vanbervliet, J. Fayette, F. Briere, J. Banchereau, and C. Caux (1998)
J. Immunol. 161, 2223-2231
 |  Abstract »  |  Full Text »  |  PDF »

A Pivotal Role of Cyclin D3 and Cyclin-Dependent Kinase Inhibitor p27 in the Regulation of IL-2-, IL-4-, or IL-10-Mediated Human B Cell Proliferation.

E. F. Wagner, M. Hleb, N. Hanna, and S. Sharma (1998)
J. Immunol. 161, 1123-1131
 |  Abstract »  |  Full Text »  |  PDF »

TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption.

B. S. Kwon, S. Wang, N. Udagawa, V. Haridas, Z. H. Lee, K. K. Kim, K.-o. Oh, J. Greene, Y. Li, J. Su, et al. (1998)
FASEB J 12, 845-854
 |  Abstract »  |  Full Text »

Affinity Maturation in Lyn Kinase-Deficient Mice with Defective Germinal Center Formation.

J. Kato, N. Motoyama, I. Taniuchi, H. Takeshita, M. Toyoda, K. Masuda, and T. Watanabe (1998)
J. Immunol. 160, 4788-4795
 |  Abstract »  |  Full Text »  |  PDF »

Functional Diversity of the CD8+ T-Cell Response to Epstein-Barr Virus (EBV): Implications for the Pathogenesis of EBV-Associated Lymphoproliferative Disorders.

R. A. Nazaruk, R. Rochford, M. V. Hobbs, and M. J. Cannon (1998)
Blood 91, 3875-3883
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Tumor Necrosis Factor Receptor-Associated Factor Signaling Proteins with the Latent Membrane Protein 1 PXQXT Motif Is Essential for Induction of Epidermal Growth Factor Receptor Expression.

W. E. Miller, J. L. Cheshire, and N. Raab-Traub (1998)
Mol. Cell. Biol. 18, 2835-2844
 |  Abstract »  |  Full Text »

Apoptosis of Malignant Human B Cells by Ligation of CD20 With Monoclonal Antibodies.

D. Shan, J. A. Ledbetter, and O. W. Press (1998)
Blood 91, 1644-1652
 |  Abstract »  |  Full Text »  |  PDF »

Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor.

A. Corcione, L. Ottonello, G. Tortolina, P. Tasso, F. Ghiotto, I. Airoldi, G. Taborelli, F. Malavasi, F. Dallegri, and V. Pistoia (1997)
Blood 90, 4493-4501
 |  Abstract »  |  Full Text »  |  PDF »

Antibodies to HLA Class I alpha 1 Domain Trigger Apoptosis of CD40-Activated Human B Lymphocytes.

L. Genestier, G. Meffre, P. Garrone, J.-J. Pin, Y.-J. Liu, J. Banchereau, and J.-P. Revillard (1997)
Blood 90, 726-735
 |  Abstract »  |  Full Text »  |  PDF »

A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation.

B. S. Kwon, K. B. Tan, J. Ni, K. K. Kim, Y.-J. Kim, S. Wang, R. Gentz, G.-L. Yu, J. Harrop, S. D. Lyn, et al. (1997)
J. Biol. Chem. 272, 14272-14276
 |  Abstract »  |  Full Text »  |  PDF »

Soluble and Membrane-bound Forms of Signaling Lymphocytic Activation Molecule (SLAM) Induce Proliferation and Ig Synthesis by Activated Human B Lymphocytes.

J. Punnonen, B. G. Cocks, J. M. Carballido, B. Bennett, D. Peterson, G. Aversa, and J. E. d. Vries (1997)
J. Exp. Med. 185, 993-1004
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes.

B. Dubois, B. Vanbervliet, J. Fayette, C. Massacrier, C. V. Kooten, F. Briere, J. Banchereau, and C. Caux (1997)
J. Exp. Med. 185, 941-952
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Human Germinal Center B Cells In Vitro.

J. D. Pound and J. Gordon (1997)
Blood 89, 919-928
 |  Abstract »  |  Full Text »  |  PDF »

CD40 Ligation on Human Cord Blood CD34+ Hematopoietic Progenitors Induces Their Proliferation and Differentiation into Functional Dendritic Cells.

L. Flores-Romo, P. Bjorck, V. Duvert, C. van Kooten, S. Saeland, and J. Banchereau (1997)
J. Exp. Med. 185, 341-350
 |  Abstract »  |  Full Text »  |  PDF »

Thymic Overexpression of CD40 Ligand Disrupts Normal Thymic Epithelial Organization.

R. J. Dunn, C. J. Luedecker, H. S. Haugen, C. H. Clegg, and A. G. Farr (1997)
J. Histochem. Cytochem. 45, 129-142
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis.

V. Sarma, Z. Lin, L. Clark, B. M. Rust, M. Tewari, R. J. Noelle, and V. M. Dixit (1995)
J. Biol. Chem. 270, 12343-12346
 |  Abstract »  |  Full Text »  |  PDF »

Immunoglobulin VH3 gene products: natural ligands for HIV gp120.

L Berberian, L Goodglick, T. Kipps, and J Braun (1993)
Science 261, 1588-1591
 |  Abstract »  |  PDF »

Induction of apoptosis by the low-affinity NGF receptor.

S Rabizadeh, J Oh, L. Zhong, J Yang, C. Bitler, L. Butcher, and D. Bredesen (1993)
Science 261, 345-348
 |  Abstract »  |  PDF »

CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.

R. Allen, R. Armitage, M. Conley, H Rosenblatt, N. Jenkins, N. Copeland, M. Bedell, S Edelhoff, C. Disteche, D. Simoneaux, et al. (1993)
Science 259, 990-993
 |  Abstract »

CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.

R. Carter and D. Fearon (1992)
Science 256, 105-107
 |  Abstract »  |  PDF »

CD45 Is Required for CD40-induced Inhibition of DNA Synthesis and Regulation of c-Jun NH2-terminal Kinase and p38 in BAL-17 B Cells.

Y. Arimura, M. Ogimoto, K. Mitomo, T. Katagiri, K.-i. Yamamoto, S. Volarevic, K. Mizuno, and H. Yakura (2001)
J. Biol. Chem. 276, 8550-8556
 |  Abstract »  |  Full Text »  |  PDF »

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