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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1743 - 1745
DOI: 10.1126/science.2176747
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Articles

Science, Vol 250, Issue 4988, 1743-1745
Copyright © 1990 by American Association for the Advancement of Science

articles

Early enhancement of calcium currents by H-ras oncoproteins injected into Hermissenda neurons

C Collin, AG Papageorge, DR Lowy, and DL Alkon

Laboratory of Molecular and Cellular Neurobiology, NINDS-NIH, Bethesda, MD 20892.

Influx of calcium through membrane channels is an important initial step in signal transduction of growth signals. Therefore, the effects of Ras protein injection on calcium currents across the soma membrane of an identified neuron of the snail Hermissenda were examined. With the use of these post-mitotic cells, a voltage-sensitive, inward calcium current was increased 10 to 20 minutes after Harvey-ras oncoproteins were injected. The effects of oncogenic Harvey ras p21 protein (v-Ras) occurred quickly and were sustained, whereas the effects of proto-oncogenic ras protein (c-Ras) were transient. This relative potency is consistent with the activities of these oncoproteins in stimulating cell proliferation. Thus, this calcium channel may be a target for Ras action.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)