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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1732 - 1735
DOI: 10.1126/science.1702902
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Articles

Science, Vol 250, Issue 4988, 1732-1735
Copyright © 1990 by American Association for the Advancement of Science

articles

Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver

J Vacher and SM Tilghman

Howard Hughes Medical Institute, Department of Biology, Princeton University, NJ 08544.

Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.


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