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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1729 - 1732
DOI: 10.1126/science.2270488
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Articles
Science, Vol 250, Issue 4988, 1729-1732
Copyright © 1990 by American Association for the Advancement of Science
Hemolin: an insect-immune protein belonging to the immunoglobulin superfamily
SC Sun,
I Lindstrom,
HG Boman,
I Faye,
and
O Schmidt
Department of Microbiology, University of Stockholm, Sweden.
Insects have an efficient defense system against infections. Their antibacterial immune proteins have been well characterized. However, the molecular mechanisms by which insects recognize foreignness are not yet known. Data are presented showing that hemolin (previously named P4), a bacteria-inducible hemolymph protein of the giant silk moth Hyalophora cecropia, belongs to the immunoglobulin superfamily. Functional analyses indicate that hemolin is one of the first hemolymph components to bind to the bacterial surface, taking part in a protein complex formation that is likely to initiate the immune response.
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