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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1726 - 1729
DOI: 10.1126/science.2125368
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Articles

Science, Vol 250, Issue 4988, 1726-1729
Copyright © 1990 by American Association for the Advancement of Science

articles

Peripheral clonal elimination of functional T cells

LA Jones, LT Chin, DL Longo, and AM Kruisbeek

Biological Response Modifiers Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

A major mechanism for generating tolerance in developing T cells is the intrathymic clonal deletion of T cells that have receptors for those self antigens that are presented on hematopoietic cells. The mechanisms of tolerance induction to antigens not expressed in the thymus remain unclear. Tolerance to self antigens can be generated extrathymically through the induction of clonal nonresponsiveness in T cells with self-reactive receptors. A second mechanism of extrathymic tolerance was identified: clonal elimination of mature T cells with self-reactive receptors that had previously displayed functional reactivity.


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