Related Content
Search Google Scholar for:
|
|
Science 21 December 1990:
Vol. 250. no. 4988, pp. 1715 - 1720
DOI: 10.1126/science.2270486
|
|
Articles
Science, Vol 250, Issue 4988, 1715-1720
Copyright © 1990 by American Association for the Advancement of Science
Inheritance of proliferative breast disease in breast cancer kindreds
MH Skolnick,
LA Cannon-Albright,
DE Goldgar,
JH Ward,
CJ Marshall,
GB Schumann,
H Hogle,
WP McWhorter,
EC Wright,
TD Tran,
and
al. et
Utah Regional Cancer Center, University of Utah Medical Center, Salt Lake City 84132.
Previous studies have emphasized that genetic susceptibility to breast cancer is rare and is expressed primarily as premenopausal breast cancer, bilateral breast cancer, or both. Proliferative breast disease (PBD) is a significant risk factor for the development of breast cancer and appears to be a precursor lesion. PBD and breast cancer were studied in 103 women from 20 kindreds that were selected for the presence of two first degree relatives with breast cancer and in 31 control women. Physical examination, screening mammography, and four-quadrant fine-needle breast aspirates were performed. Cytologic analysis of breast aspirates revealed PBD in 35% of clinically normal female first degree relatives of breast cancer cases and in 13% of controls. Genetic analysis suggests that genetic susceptibility causes both PBD and breast cancer in these kindreds. This study supports the hypothesis that this susceptibility is responsible for a considerable portion of breast cancer, including unilateral and postmenopausal breast cancer.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Comparison of Ductal Lavage and Random Periareolar Fine Needle Aspiration as Tissue Acquisition Methods in Early Breast Cancer Prevention Trials.
- B. Arun, V. Valero, C. Logan, K. Broglio, E. Rivera, A. Brewster, G. Yin, M. Green, H. Kuerer, Y. Gong, et al. (2007)
Clin. Cancer Res.
13, 4943-4948
| Abstract »
| Full Text »
| PDF »
- Population-Based Analysis of Prognostic Factors and Survival in Familial Melanoma.
- S. R. Florell, K. M. Boucher, G. Garibotti, J. Astle, R. Kerber, G. Mineau, C. Wiggins, R. D. Noyes, A. Tsodikov, L. A. Cannon-Albright, et al. (2005)
J. Clin. Oncol.
23, 7168-7177
| Abstract »
| Full Text »
| PDF »
- Breast-tissue sampling for risk assessment and prevention.
- C J Fabian, B F Kimler, M S Mayo, and S A Khan (2005)
Endocr. Relat. Cancer
12, 185-213
| Abstract »
| Full Text »
| PDF »
- Risk assessment and management of high risk familial breast cancer.
- D G R Evans and F Lalloo (2002)
J. Med. Genet.
39, 865-871
| Abstract »
| Full Text »
| PDF »
- Management of women with a family history of breast cancer in the North West Region of England: training for implementing a vision of the future.
- M McAllister, K O'Malley, P Hopwood, B Kerr, A Howell, and D G R Evans (2002)
J. Med. Genet.
39, 531-535
| Full Text »
| PDF »
- Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation.
- H. Meijers-Heijboer, B. van Geel, W. L.J. van Putten, S. C. Henzen-Logmans, C. Seynaeve, M. B.E. Menke-Pluymers, C. C.M. Bartels, L. C. Verhoog, A. M.W. van den Ouweland, M. F. Niermeijer, et al. (2001)
N. Engl. J. Med.
345, 159-164
| Abstract »
| Full Text »
| PDF »
- Tamoxifen, Raloxifene, and the Prevention of Breast Cancer.
- V. C. Jordan and M. Morrow (1999)
Endocr. Rev.
20, 253-278
| Abstract »
| Full Text »
- Psychological Issues in Genetic Testing for Breast Cancer Susceptibility.
- C. Lerman and R. Croyle (1994)
Arch Intern Med
154, 609-616
| Abstract »
| PDF »
- Fortnightly Review: Familial breast cancer.
- D G R Evans, I S Fentiman, K McPherson, D Asbury, B A J Ponder, and A Howell (1994)
BMJ
308, 183-187
| Abstract »
| Full Text »
- Breast cancer: two steps closer to understanding.
- K Wright (1990)
Science
250, 1659
| PDF »
|
|
