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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1707 - 1708
DOI: 10.1126/science.2270484
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Articles

Science, Vol 250, Issue 4988, 1707-1708
Copyright © 1990 by American Association for the Advancement of Science

articles

Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome

AN Mayeno, F Lin, CS Foote, DA Loegering, MM Ames, CW Hedberg, and GJ Gleich

Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan N alpha-animal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1'-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of L-Tryptophan Supplementation on Eosinophils and Eotaxin in Guinea Pigs.
J. L. Stahl, E. B. Cook, M. A. Pariza, M. E. Cook, and F. M. Graziano (2001)
Experimental Biology and Medicine 226, 177-184
   Abstract »    Full Text »
Dot-like focal contacts in adherent eosinophils, their redistribution into peripheral belts, and correlated effects on cell migration and protected zone formation.
A Tourkin, M Bonner, E Mantrova, E. LeRoy, and S Hoffman (1996)
J. Cell Sci. 109, 2169-2177
   Abstract »    PDF »
A new cofactor in a prokaryotic enzyme: tryptophan tryptophylquinone as the redox prosthetic group in methylamine dehydrogenase.
W. McIntire, D. Wemmer, A Chistoserdov, and M. Lidstrom (1991)
Science 252, 817-824
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)