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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1694 - 1699
DOI: 10.1126/science.2176744
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Articles

Science, Vol 250, Issue 4988, 1694-1699
Copyright © 1990 by American Association for the Advancement of Science

articles

Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator

IJ Mohr, R Clark, S Sun, EJ Androphy, P MacPherson, and MR Botchan

Department of Molecular and Cell Biology, University of California, Berkely 94720.

The mechanism by which transcription factors stimulate DNA replication in eukaryotes is unknown. Bovine papillomavirus DNA synthesis requires the products of the viral E1 gene and the transcriptional activator protein encoded by the E2 gene. Experimental data showed that the 68-kilodalton (kD) E1 protein formed a complex with the 48-kD E2 transcription factor. This complex bound specifically to the viral origin of replication, which contains multiple binding sites for E2. Repressor proteins encoded by the E2 open reading frame failed to complex with E1 suggesting that the 162-amino acid region of E2 that participates in transactivation contained critical determinants for interaction with E1. The physical association between a replication protein and a transcription factor suggests that transcriptional activator proteins may function in targeting replication initiator proteins to their respective origins of replication.


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Distinct Roles of Two Binding Sites for the Bovine Papillomavirus (BPV) E2 Transactivator on BPV DNA Replication.
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Transcription Factor YY1 Represses Cell-Free Replication from Human Papillomavirus Origins.
K.-Y. Lee, T. R. Broker, and L. T. Chow (1998)
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J. Virol. 72, 3925-3934
   Abstract »    Full Text »    PDF »
Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation.
C. W. Lehman and M. R. Botchan (1998)
PNAS 95, 4338-4343
   Abstract »    Full Text »    PDF »
Characterization of the DNA-Binding Domain of the Bovine Papillomavirus Replication Initiator E1.
G. Chen and A. Stenlund (1998)
J. Virol. 72, 2567-2576
   Abstract »    Full Text »    PDF »
The Carboxyl-Terminal Region of the Human Papillomavirus Type 16 E1 Protein Determines E2 Protein Specificity during DNA Replication.
N. Zou, J.-S. Liu, S.-R. Kuo, T. R. Broker, and L. T. Chow (1998)
J. Virol. 72, 3436-3441
   Abstract »    Full Text »    PDF »
Association of the Human Papillomavirus Type 11 E1 Protein with Histone H1.
C. S. Swindle and J. A. Engler (1998)
J. Virol. 72, 1994-2001
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Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin.
M. H. Skiadopoulos and A. A. McBride (1998)
J. Virol. 72, 2079-2088
   Abstract »    Full Text »    PDF »
Differential Requirements for Conserved E2 Binding Sites in the Life Cycle of Oncogenic Human Papillomavirus Type 31.
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J. Virol. 72, 1071-1077
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The Papillomavirus Minor Capsid Protein, L2, Induces Localization of the Major Capsid Protein, L1, and the Viral Transcription/Replication Protein, E2, to PML Oncogenic Domains.
P. M. Day, R. B. S. Roden, D. R. Lowy, and J. T. Schiller (1998)
J. Virol. 72, 142-150
   Abstract »    Full Text »    PDF »
Transient Viral DNA Replication and Repression of Viral Transcription Are Supported by the C-Terminal Domain of the Bovine Papillomavirus Type 1 E1 Protein.
M. C. Ferran and A. A. McBride (1998)
J. Virol. 72, 796-801
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The Functions of Human Papillomavirus Type 11 E1, E2, and E2C Proteins in Cell-free DNA Replication.
J.-S. Liu, S.-R. Kuo, T. R. Broker, and L. T. Chow (1995)
J. Biol. Chem. 270, 27283-27291
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Site-specific DNA-binding Proteins Important for Replication and Transcription Have Multiple Activities.
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Cold Spring Harb Symp Quant Biol 58, 403-413
   Abstract »    PDF »
A yeast chromosomal origin of DNA replication defined by multiple functional elements.
Y Marahrens and B Stillman (1992)
Science 255, 817-823
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Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 trans-activator..
S S Prakash, S R Grossman, R B Pepinsky, L A Laimins, and E J Androphy (1992)
Genes & Dev. 6, 105-116
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The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex..
N Dostatni, P F Lambert, R Sousa, J Ham, P M Howley, and M Yaniv (1991)
Genes & Dev. 5, 1657-1671
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Oct-3 and the beginning of mammalian development.
M. Rosner, M. Vigano, P. Rigby, H Arnheiter, and L. Staudt (1991)
Science 253, 144-145
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Transcription Factor E2 Regulates BPV-1 DNA Replication In Vitro by Direct Protein-Protein Interaction.
L. Yang, I. Mohr, R. Li, T. Nottoli, S. Sun, and M. Botchan (1991)
Cold Spring Harb Symp Quant Biol 56, 335-346
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Mechanism and Requirements for Bovine Papillomavirus, Type 1, E1 Initiator Complex Assembly Promoted by the E2 Transcription Factor Bound to Distal Sites.
C. M. Sanders and A. Stenlund (2001)
J. Biol. Chem. 276, 23689-23699
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Characterization of Recombinant HPV6 and 11 E1 Helicases. EFFECT OF ATP ON THE INTERACTION OF E1 WITH E2 AND MAPPING OF A MINIMAL HELICASE DOMAIN.
P. W. White, A. Pelletier, K. Brault, S. Titolo, E. Welchner, L. Thauvette, M. Fazekas, M. G. Cordingley, and J. Archambault (2001)
J. Biol. Chem. 276, 22426-22438
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