Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Active Motif, Inc.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 December 1990:
Vol. 250. no. 4986, pp. 1426 - 1429
DOI: 10.1126/science.2255914
Prev | Table of Contents | Next

Articles

Science, Vol 250, Issue 4986, 1426-1429
Copyright © 1990 by American Association for the Advancement of Science

articles

Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity

PD Aplan, DP Lombardi, AM Ginsberg, J Cossman, VL Bertness, and IR Kirsch

National Cancer Institute-Navy Medical Oncology Branch, Naval Hospital, Bethesda, MD 20889-5105.

A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL. The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL. Similar to 1;14 translocations, this deletion disrupts the SCL 5' regulatory region. This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin or a T cell receptor. Two other T cell lines, CEM and RPMI 8402, have essentially identical deletions. Thus, in lymphocytes, growth-affecting genes other than immune receptors risk rearrangements.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies.
M. Zhang and P. C. Swanson (2008)
J. Biol. Chem. 283, 6717-6727
   Abstract »    Full Text »    PDF »
p16INK4A tumor suppressor gene expression and CD3{epsilon} deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
M. Fasseu, P. D. Aplan, M. Chopin, N. Boissel, J.-C. Bories, J. Soulier, H. von Boehmer, F. Sigaux, and A. Regnault (2007)
Blood 110, 2610-2619
   Abstract »    Full Text »    PDF »
The Zebra fish cassiopeia Mutant Reveals that SIL Is Required for Mitotic Spindle Organization.
K. L. Pfaff, C. T. Straub, K. Chiang, D. M. Bear, Y. Zhou, and L. I. Zon (2007)
Mol. Cell. Biol. 27, 5887-5897
   Abstract »    Full Text »    PDF »
V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development.
J. M. Murray, J. P. O'Neill, T. Messier, J. Rivers, V. E. Walker, B. McGonagle, L. Trombley, L. G. Cowell, G. Kelsoe, F. McBlane, et al. (2006)
J. Immunol. 177, 5393-5404
   Abstract »    Full Text »    PDF »
Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites.
G. A. Follows, P. Dhami, B. Gottgens, A. W. Bruce, P. J. Campbell, S. C. Dillon, A. M. Smith, C. Koch, I. J. Donaldson, M. A. Scott, et al. (2006)
Genome Res. 16, 1310-1319
   Abstract »    Full Text »    PDF »
Leukemia and lymphoma: a cost of doing business for adaptive immunity..
M. S. Schlissel, C. R. Kaffer, and J. D. Curry (2006)
Genes & Dev. 20, 1539-1544
   Full Text »    PDF »
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates.
D. Huangfu and K. V. Anderson (2006)
Development 133, 3-14
   Abstract »    Full Text »    PDF »
Sil Phosphorylation in a Pin1 Binding Domain Affects the Duration of the Spindle Checkpoint.
S. Campaner, P. Kaldis, S. Izraeli, and I. R. Kirsch (2005)
Mol. Cell. Biol. 25, 6660-6672
   Abstract »    Full Text »    PDF »
SCL Expression at Critical Points in Human Hematopoietic Lineage Commitment.
Y. Zhang, K. J. Payne, Y. Zhu, M. A. Price, Y. K. Parrish, E. Zielinska, L. W. Barsky, and G. M. Crooks (2005)
Stem Cells 23, 852-860
   Abstract »    Full Text »    PDF »
Involvement of Illegitimate V(D)J Recombination or Microhomology-Mediated Nonhomologous End-Joining in the Formation of Intragenic Deletions of the Notch1 Gene in Mouse Thymic Lymphomas.
H. Tsuji, H. Ishii-Ohba, T. Katsube, H. Ukai, S. Aizawa, M. Doi, K. Hioki, and T. Ogiu (2004)
Cancer Res. 64, 8882-8890
   Abstract »    Full Text »    PDF »
Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in {gamma}-ray-induced thymic lymphomas and in normal thymus of the mouse.
J. Sakata, J. Inoue, H. Ohi, H. Kosugi-Okano, Y. Mishima, K. Hatakeyama, O. Niwa, and R. Kominami (2004)
Carcinogenesis 25, 1069-1075
   Abstract »    Full Text »    PDF »
Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia.
B. J. P. Huntly, A. Bench, and A. R. Green (2003)
Blood 102, 1160-1168
   Abstract »    Full Text »    PDF »
A molecular dosimetry approach to assess human exposure to environmental tobacco smoke in pubs.
A. Besaratinia, L.M. Maas, E.M.C. Brouwer, E.J.C. Moonen, T.M.C.M. De Kok, G.J. Wesseling, S. Loft, J.C.S. Kleinjans, and F.J. Van Schooten (2002)
Carcinogenesis 23, 1171-1176
   Abstract »    Full Text »    PDF »
Phosphorylation by Mitogen-activated Protein Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription Factor in Endothelial Cells.
T. Tang, J. L. Arbiser, and S. J. Brandt (2002)
J. Biol. Chem. 277, 18365-18372
   Abstract »    Full Text »    PDF »
Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors.
C. J. Williams, I. Grandal, D. J. Vesprini, U. Wojtyra, J. S. Danska, and C. J. Guidos (2001)
Mol. Cell. Biol. 21, 400-413
   Abstract »    Full Text »
V(D)J recombinase-mediated transposition of the BCL2 gene to the IGH locus in follicular lymphoma.
J.-W. Vaandrager, E. Schuuring, K. Philippo, and P. M. Kluin (2000)
Blood 96, 1947-1952
   Abstract »    Full Text »    PDF »
Postcleavage Sequence Specificity in V(D)J Recombination.
E. A. Agard and S. M. Lewis (2000)
Mol. Cell. Biol. 20, 5032-5040
   Abstract »    Full Text »
Acquired DNA mutations associated with in vivo hydroxyurea exposure.
V. N. Hanft, S. R. Fruchtman, C. V. Pickens, W. F. Rosse, T. A. Howard, and R. E. Ware (2000)
Blood 95, 3589-3593
   Abstract »    Full Text »    PDF »
Erythroid-specific Inhibition of the tal-1 Intragenic Promoter Is Due to Binding of a Repressor to a Novel Silencer.
C. Courtes, N. Lecointe, L. Le Cam, F. Baudoin, C. Sardet, and D. Mathieu-Mahul (2000)
J. Biol. Chem. 275, 949-958
   Abstract »    Full Text »    PDF »
Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient Mice.
D. S. Chervinsky, X.-F. Zhao, D. H. Lam, M. Ellsworth, K. W. Gross, and P. D. Aplan (1999)
Mol. Cell. Biol. 19, 5025-5035
   Abstract »    Full Text »    PDF »
The SCL Gene: From Case Report to Critical Hematopoietic Regulator.
C. G. Begley and A. R. Green (1999)
Blood 93, 2760-2770
   Full Text »    PDF »
Development and Validation of a Quantitative Polymerase Chain Reaction Assay to Evaluate Minimal Residual Disease for T-Cell Acute Lymphoblastic Leukemia and Follicular Lymphoma.
G. A. Hosler, R. O. Bash, X. Bai, V. Jain, and R. H. Scheuermann (1999)
Am. J. Pathol. 154, 1023-1035
   Abstract »    Full Text »    PDF »
Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns.
M. Yoshioka, P. M. Vacek, T. Poseno, R. Silver, and B. A. Finette (1999)
PNAS 96, 586-591
   Abstract »    Full Text »    PDF »
The Hematopoietic Transcription Factor SCL Binds the p44 Subunit of TFIIH.
X.-F. Zhao and P. D. Aplan (1999)
J. Biol. Chem. 274, 1388-1393
   Abstract »    Full Text »    PDF »
The Mechanism of Chromosome 7 Inversion in Human Lymphocytes Expressing Chimeric {gamma}{beta} TCR.
C. Retiere, F. Halary, M.-A. Peyrat, F. Le Deist, M. Bonneville, and M.-M. Hallet (1999)
J. Immunol. 162, 903-910
   Abstract »    Full Text »    PDF »
ETV6-AML1 Translocation Breakpoints Cluster Near a Purine/Pyrimidine Repeat Region in the ETV6 Gene.
S. P. Thandla, J. E. Ploski, S. Z. Raza-Egilmez, P. P. Chhalliyil, A. W. Block, P. J. de Jong, and P. D. Aplan (1999)
Blood 93, 293-299
   Abstract »    Full Text »    PDF »
Transcription Factor SCL Is Required for c-kit Expression and c-Kit Function in Hemopoietic Cells.
G. Krosl, G. He, M. Lefrancois, F. Charron, P.-H. Romeo, P. Jolicoeur, I. R. Kirsch, M. Nemer, and T. Hoang (1998)
J. Exp. Med. 188, 439-450
   Abstract »    Full Text »    PDF »
Multiplex Reverse Transcription-Polymerase Chain Reaction for Simultaneous Screening of 29 Translocations and Chromosomal Aberrations in Acute Leukemia.
N. Pallisgaard, P. Hokland, D. C. Riishoj, B. Pedersen, and P. Jorgensen (1998)
Blood 92, 574-588
   Abstract »    Full Text »    PDF »
Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia.
F. M. Uckun, M. G. Sensel, L. Sun, P. G. Steinherz, M. E. Trigg, N. A. Heerema, H. N. Sather, G. H. Reaman, and P. S. Gaynon (1998)
Blood 91, 735-746
   Full Text »    PDF »
SCL specifies hematopoietic mesoderm in Xenopus embryos.
P. Mead, C. Kelley, P. Hahn, O Piedad, and L. Zon (1998)
Development 125, 2611-2620
   Abstract »    PDF »
Disruption of the Multiple Tumor Suppressor Gene MTS1/p16INK4a/CDKN2 by Illegitimate V(D)J Recombinase Activity in T-Cell Acute Lymphoblastic Leukemias.
J.-M. Cayuela, B. Gardie, and F. Sigaux (1997)
Blood 90, 3720-3726
   Abstract »    Full Text »    PDF »
Target-dependent Effect of Phosphorylation on the DNA Binding Activity of the TAL1/SCL Oncoprotein.
K. S.S. Prasad and S. J. Brandt (1997)
J. Biol. Chem. 272, 11457-11462
   Abstract »    Full Text »    PDF »
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia..
S P Hunger, K Ohyashiki, K Toyama, and M L Cleary (1992)
Genes & Dev. 6, 1608-1620
   Abstract »    PDF »
Chromosome aberrations and cancer.
E Solomon, J Borrow, and A. Goddard (1991)
Science 254, 1153-1160
   Abstract »    PDF »
Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints.
S. C. Raghavan, I. R. Kirsch, and M. R. Lieber (2001)
J. Biol. Chem. 276, 29126-29133
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)