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Science 7 December 1990:
Vol. 250. no. 4986, pp. 1421 - 1423
DOI: 10.1126/science.2175047
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Articles

Science, Vol 250, Issue 4986, 1421-1423
Copyright © 1990 by American Association for the Advancement of Science

articles

Efficient incorporation of human CD4 protein into avian leukosis virus particles

JA Young, P Bates, K Willert, and HE Varmus

Department of Microbiology and Immunology, University of California School of Medicine, San Francisco 94143.

Virus envelope (Env) proteins are thought to contain specific signals for selective uptake by virus particles. In the course of attempting to define these signals by testing virus incorporation of CD4-Env chimeric proteins, normal human CD4 was found to be efficiently and selectively assembled into avian leukosis virus particles in quail cells. Viruses bearing CD4 at their surface may be useful reagents in the design of retrovirus-mediated gene therapy for the acquired immune deficiency syndrome.


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