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Science 7 December 1990:
Vol. 250. no. 4986, pp. 1377 - 1382
DOI: 10.1126/science.2255907
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Articles

Science, Vol 250, Issue 4986, 1377-1382
Copyright © 1990 by American Association for the Advancement of Science

articles

How big is the universe of exons?

RL Dorit, L Schoenbach, and W Gilbert

Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.

If genes have been assembled from exon subunits, the frequency with which exons are reused leads to an estimate of the size of the underlying exon universe. An exon database was constructed from available protein sequences, and homologous exons were identified on the basis of amino acid identity; statistically significant matches were determined by Monte Carlo methods. It is estimated that only 1000 to 7000 exons were needed to construct all proteins.


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