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Science 30 November 1990:
Vol. 250. no. 4985, pp. 1269 - 1273
DOI: 10.1126/science.1978758
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Articles

Science, Vol 250, Issue 4985, 1269-1273
Copyright © 1990 by American Association for the Advancement of Science

articles

Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells

P Fisch, M Malkovsky, S Kovats, E Sturm, E Braakman, BS Klein, SD Voss, LW Morrissey, R DeMars, WJ Welch, and al. et

Department of Human Oncology, University of Wisconsin, Madison 53792.

All human gamma delta T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments V gamma 9 and V delta 2 recognize antigens from mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood gamma delta T cells. Stimulation of human V gamma 9/V delta 2 T cells is not restricted by human leukocyte antigens (HLA), including nonpolymorphic beta 2-microglobulin (beta 2M)-associated class Ib molecules. These data may be important for understanding the role of gamma delta T cells in autoimmunity and in responses to microorganisms and tumors.


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