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Science 30 November 1990:
Vol. 250. no. 4985, pp. 1266 - 1269
DOI: 10.1126/science.2173861
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Articles

Science, Vol 250, Issue 4985, 1266-1269
Copyright © 1990 by American Association for the Advancement of Science

articles

Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells

HR Wirtz and LG Dobbs

Cardiovascular Research Institute, University of California, San Francisco 94143-0130.

Deep inflation of the lung stimulates surfactant secretion by unknown mechanisms. The hypothesis that mechanical distension directly stimulates type II cells to secrete surfactant was tested by stretching type II cells cultured on silastic membranes. The intracellular Ca2+ concentration was measured in single cells, before and after stretching. A single stretch of alveolar type II cells caused a transient (less than 60 seconds) increase in cytosolic Ca2+ followed by a sustained (15 to 30 minutes) stimulation of surfactant secretion. Both Ca2+ mobilization and exocytosis exhibited dose-dependence to the magnitude of the stretch-stimulus. Thus, mechanical factors can trigger complex cellular events in nonneuron, nonmuscle cells and may be involved in regulating normal lung functions.


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Stretch induces cytokine release by alveolar epithelial cells in vitro.
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Prostaglandin E2 integrates the effects of fluid distension and glucocorticoid on lung maturation.
J. S. Torday, H. Sun, and J. Qin (1998)
Am J Physiol Lung Cell Mol Physiol 274, L106-L111
   Abstract »    Full Text »    PDF »
Wound-induced calcium waves in alveolar type II cells.
L. E. Hinman, G. J. Beilman, K. E. Groehler, and P. J. Sammak (1997)
Am J Physiol Lung Cell Mol Physiol 273, L1242-L1248
   Abstract »    Full Text »    PDF »
Extended Preservation of Ischemic Pulmonary Graft by Postmortem Alveolar Expansion.
D. E. M. Van Raemdonck, N. C. P. Jannis, F. R. L. Rega, P. R. J. De Leyn, W. J. Flameng, and T. E. Lerut (1997)
Ann. Thorac. Surg. 64, 801-808
   Abstract »    Full Text »
Vascular Distension and Continued Ventilation Are Protective in Lung Ischemia/Reperfusion.
H. SCHÜTTE, G. HERMLE, W. SEEGER, and F. GRIMMINGER (1997)
Am. J. Respir. Crit. Care Med. 157, 171-177
   Abstract »    Full Text »
Natriuretic Peptides Inhibit DNA Synthesis in Cardiac Fibroblasts.
L. Cao and D. G. Gardner (1995)
Hypertension 25, 227-234
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