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Science 30 November 1990:
Vol. 250. no. 4985, pp. 1259 - 1262
DOI: 10.1126/science.2244209
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Articles

Science, Vol 250, Issue 4985, 1259-1262
Copyright © 1990 by American Association for the Advancement of Science

articles

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

FJ Rauscher 3rd, JF Morris, OE Tournay, DM Cook, and T Curran

Wistar Institute, Philadelphia, PA 19104.

The Wilms' tumor locus (WTL) at 11p13 contains a gene that encodes a zinc finger-containing protein that has characteristics of a DNA-binding protein. However, binding of this protein to DNA in a sequence-specific manner has not been demonstrated. A synthetic gene was constructed that contained the zinc finger region, and the protein was expressed in Escherichia coli. The recombinant protein was used to identify a specific DNA binding site from a pool of degenerate oligonucleotides. The binding sites obtained were similar to the sequence recognized by the early growth response-1 (EGR-1) gene product, a zinc finger-containing protein that is induced by mitogenic stimuli. A mutation in the zinc finger region of the protein originally identified in a Wilms' tumor patient abolished its DNA-binding activity. These results suggest that the WTL protein may act at the DNA binding site of a growth factor-inducible gene and that loss of DNA-binding activity contributes to the tumorigenic process.


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J. Biol. Chem. 272, 33056-33061
   Abstract »    Full Text »    PDF »
PAX 8 Regulates Human WT1 Transcription through a Novel DNA Binding Site.
G. C. Fraizer, R. Shimamura, X. Zhang, and G. F. Saunders (1997)
J. Biol. Chem. 272, 30678-30687
   Abstract »    Full Text »    PDF »
The Kruppel-associated Box (KRAB)-Zinc Finger Protein Kid-1 and the Wilms' Tumor Protein WT1, Two Transcriptional Repressor Proteins, Bind to Heteroduplex DNA.
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J. Biol. Chem. 272, 27908-27912
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Regulation of Osteoclastogenesis by Antisense Oligodeoxynucleotides Specific to Zinc Finger Nuclear Transcription Factors Egr-1 and WT1 in Rat Bone Marrow Culture System.
T. Kukita, A. Kukita, H. Harada, and T. Iijima (1997)
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Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein.
J.-Y. Li, M. A. English, H. J. Ball, P. L. Yeyati, S. Waxman, and J. D. Licht (1997)
J. Biol. Chem. 272, 22447-22455
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FGF-1–Induced Platelet-Derived Growth Factor-A Chain Gene Expression in Endothelial Cells Involves Transcriptional Activation by Early Growth Response Factor-1.
G. J. Delbridge and L. M. Khachigian (1997)
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J. Biol. Chem. 272, 19609-19614
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Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer.
G. B. Silberstein, K. Van Horn, P. Strickland, C. T. Roberts Jr., and C. W. Daniel (1997)
PNAS 94, 8132-8137
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Transcription Factors, Normal Myeloid Development, and Leukemia.
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Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology.
V. Schumacher, S. Schneider, A. Figge, G. Wildhardt, D. Harms, D. Schmidt, A. Weirich, R. Ludwig, and B. Royer-Pokora (1997)
PNAS 94, 3972-3977
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E. Karnieli, H. Werner, F. J. Rauscher III, L. E. Benjamin, and D. LeRoith (1996)
J. Biol. Chem. 271, 19304-19309
   Abstract »    Full Text »    PDF »
Differential Function of Wilms' Tumor Gene WT1 Splice Isoforms in Transcriptional Regulation.
S. M. Hewitt, G. C. Fraizer, Y.-J. Wu, F. J. Rauscher III, and G. F. Saunders (1996)
J. Biol. Chem. 271, 8588-8592
   Abstract »    Full Text »    PDF »
A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms.
W. Bruening and J. Pelletier (1996)
J. Biol. Chem. 271, 8646-8654
   Abstract »    Full Text »    PDF »
The Transcriptional Effect of WT1 Is Modulated by Choice of Expression Vector.
J. C. Reddy, S. Hosono, and J. D. Licht (1995)
J. Biol. Chem. 270, 29976-29982
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Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells.
L. M. Khachigian, A. J. Williams, and T. Collins (1995)
J. Biol. Chem. 270, 27679-27686
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Repression of the c-myb Gene by WT1 Protein in T and B Cell Lines.
S. McCann, J. Sullivan, J. Guerra, M. Arcinas, and L. M. Boxer (1995)
J. Biol. Chem. 270, 23785-23789
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The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis..
S Maheswaran, C Englert, P Bennett, G Heinrich, and D A Haber (1995)
Genes & Dev. 9, 2143-2156
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WT1-mediated Transcriptional Activation Is Inhibited by Dominant Negative Mutant Proteins.
J. C. Reddy, J. C. Morris, J. Wang, M. A. English, D. A. Haber, Y. Shi, and J. D. Licht (1995)
J. Biol. Chem. 270, 10878-10884
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Identification of a Nuclear Factor-I Family Protein-binding Site in the Silencer Region of the Cartilage Matrix Protein Gene.
P. Szabó, J. Moitra, A. Rencendorj, Gáb. Rákhely, T. Rauch, and I. Kiss (1995)
J. Biol. Chem. 270, 10212-10221
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Characterization of the Human Inosine-5`-monophosphate Dehydrogenase Type II Gene.
A. G. Zimmermann, J. Spychala, and B. S. Mitchell (1995)
J. Biol. Chem. 270, 6808-6814
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Promoter Elements of the Mouse Acetylcholinesterase Gene.
A. Mutero, S. Camp, and P. Taylor (1995)
J. Biol. Chem. 270, 1866-1872
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Repression of Pax-2 by WT1 during normal kidney development.
G Ryan, V Steele-Perkins, J. Morris, F. Rauscher, and G. Dressler (1995)
Development 121, 867-875
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RNA editing in the Wilms' tumor susceptibility gene, WT1..
P M Sharma, M Bowman, S L Madden, F J Rauscher, and S Sukumar (1994)
Genes & Dev. 8, 720-731
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Novel Oncogenic Mutations in the WT1 Wilms' Tumor Suppressor Gene: A t(11;22) Fuses the Ewing's Sarcoma Gene, EWS1, to WT1 in Desmoplastic Small Round Cell Tumor.
F.J. Rauscher III, L.E. Benjamin, W.J. Fredericks, and J.F. Morris (1994)
Cold Spring Harb Symp Quant Biol 59, 137-146
   Abstract »    PDF »
Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268..
K Yamagata, W E Kaufmann, A Lanahan, M Papapavlou, C A Barnes, K I Andreasson, and P F Worley (1994)
Learn. Mem. 1, 140-152
   Abstract »    PDF »
WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.
D. Haber, S Park, S Maheswaran, C Englert, G. Re, D. Hazen-Martin, D. Sens, and A. Garvin (1993)
Science 262, 2057-2059
   Abstract »    PDF »
Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues.
S. Mundlos, J. Pelletier, A. Darveau, M. Bachmann, A. Winterpacht, and B. Zabel (1993)
Development 119, 1329-1341
   Abstract »    PDF »
Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
N. Pavletich and C. Pabo (1993)
Science 261, 1701-1707
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Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain.
J. Gogos, T Hsu, J Bolton, and F. Kafatos (1992)
Science 257, 1951-1955
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Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
I. Drummond, S. Madden, P Rohwer-Nutter, G. Bell, V. Sukhatme, and F. Rauscher 3rd (1992)
Science 257, 674-678
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Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript.
W. Bickmore, K Oghene, M. Little, A Seawright, V van Heyningen, and N. Hastie (1992)
Science 257, 235-237
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Identification of a zinc finger protein that inhibits IL-2 gene expression.
T. Williams, D Moolten, J Burlein, J Romano, R Bhaerman, A Godillot, M Mellon, F. Rauscher 3rd, and J. Kant (1991)
Science 254, 1791-1794
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Tumor suppressor genes.
R. Weinberg (1991)
Science 254, 1138-1146
   Abstract »    PDF »
Transcriptional repression mediated by the WT1 Wilms tumor gene product.
S. Madden, D. Cook, J. Morris, A Gashler, V. Sukhatme, and F. Rauscher III (1991)
Science 253, 1550-1553
   Abstract »    PDF »
Expression of the Wilms' tumor gene WT1 in the murine urogenital system..
J Pelletier, M Schalling, A J Buckler, A Rogers, D A Haber, and D Housman (1991)
Genes & Dev. 5, 1345-1356
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Molecular Mechanisms of Genetic Deregulation in Toxicity and Carcinogenesis July 20-25, 1991, The Gant Conference Center, Aspen, Colorado: Program and Abstracts.
B. F. Trump (1991)
Toxicol Pathol 19, 625-669
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The Gut-enriched Kruppel-like Factor (Kruppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21WAF1/Cip1 Promoter.
W. Zhang, D. E. Geiman, J. M. Shields, D. T. Dang, C. S. Mahatan, K. H. Kaestner, J. R. Biggs, A. S. Kraft, and V. W. Yang (2000)
J. Biol. Chem. 275, 18391-18398
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J. Biol. Chem. 276, 16817-16823
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A Functional Interaction with CBP Contributes to Transcriptional Activation by the Wilms Tumor Suppressor WT1.
W. Wang, S. B. Lee, R. Palmer, L. W. Ellisen, and D. A. Haber (2001)
J. Biol. Chem. 276, 16810-16816
   Abstract »    Full Text »    PDF »
The Zinc Finger Domain of Tzfp Binds to the tbs Motif Located at the Upstream Flanking Region of the Aie1 (aurora-C) Kinase Gene.
C.-J. C. Tang, C.-K. Chuang, H.-M. Hu, and T. K. Tang (2001)
J. Biol. Chem. 276, 19631-19639
   Abstract »    Full Text »    PDF »
Molecular genetics of chromosome translocations involving EWS and related family members.
J. KIM and J. PELLETIER (1999)
Physiol Genomics 1, 127-138
   Abstract »    Full Text »    PDF »


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