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Science 30 November 1990:
Vol. 250. no. 4985, pp. 1227 - 1233
DOI: 10.1126/science.1700865
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Articles

Science, Vol 250, Issue 4985, 1227-1233
Copyright © 1990 by American Association for the Advancement of Science

articles

Retroviral recombination and reverse transcription

WS Hu and HM Temin

McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706.

Recombination occurs at a high rate in retroviral replication, and its observation requires a virion containing two different RNA molecules (heterodimeric particles). Analysis of retroviral recombinants formed after a single round of replication revealed that (i) the nonselected markers changed more frequently than expected from the rate of recombination of selected markers; (ii) the transfer of the initially synthesized minus strand strong stop DNA was either intramolecular or intermolecular; (iii) the transfer of the first synthesized plus strand strong stop DNA was always intramolecular; and (iv) there was a strong correlation between the type of transfer of the minus strand strong stop DNA and the number of template switches observed. These data suggest that retroviral recombination is ordered and occurs during the synthesis of both minus and plus strand DNA.


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J. A. Anderson, R. J. Teufel II, P. D. Yin, and W.-S. Hu (1998)
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Retroviral Recombination Rates Do Not Increase Linearly with Marker Distance and Are Limited by the Size of the Recombining Subpopulation.
J. A. Anderson, E. H. Bowman, and W.-S. Hu (1998)
J. Virol. 72, 1195-1202
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Replication Errors during In Vivo Ty1 Transposition Are Linked to Heterogeneous RNase H Cleavage Sites.
E. H. Mules, O. Uzun, and A. Gabriel (1998)
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J. DeStefano, J. Ghosh, B. Prasad, and A. Raja (1998)
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Evidence for a Unique Mechanism of Strand Transfer from the Transactivation Response Region of HIV-1.
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G. M. Fuentes, C. Palaniappan, P. J. Fay, and R. A. Bambara (1996)
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