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Science 23 November 1990:
Vol. 250. no. 4984, pp. 1149 - 1151
DOI: 10.1126/science.2251503
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Articles

Science, Vol 250, Issue 4984, 1149-1151
Copyright © 1990 by American Association for the Advancement of Science

articles

Sequence-specific DNA binding by the c-Myc protein

TK Blackwell, L Kretzner, EM Blackwood, RN Eisenman, and H Weintraub

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc contains a basic--helix-loop-helix (bHLH) motif, which is important for dimerization and specific DNA binding, as demonstrated for other bHLH protein family members. Of those studied, most bHLH proteins bind to sites that contain a CA- -TG consensus. In this study, the technique of selected and amplified binding-sequence (SAAB) imprinting was used to identify a DNA sequence that was recognized by c-Myc. A purified carboxyl-terminal fragment of human c-Myc that contained the bHLH domain bound in vitro in a sequence-specific manner to the sequence, CACGTG. These results suggest that some of the biological functions of Myc family proteins are accomplished by sequence-specific DNA binding that is mediated by the carboxyl-terminal region of the protein.


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Nucleic Acids Res. 28, 2268-2275
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Regulation of the Pancreatic Islet-Specific Gene BETA2 (neuroD) by Neurogenin 3.
H.-P. Huang, M. Liu, H. M. El-Hodiri, K. Chu, M. Jamrich, and M.-J. Tsai (2000)
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T. Brunner, S. Kasibhatla, M. J. Pinkoski, C. Frutschi, N. J. Yoo, F. Echeverri, A. Mahboubi, and D. R. Green (2000)
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M. A.F. Daggett, D. A. Rice, and L. L. Heckert (2000)
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c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis.
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Mol. Cell. Biol. 20, 1162-1169
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K. E. Boyd and P. J. Farnham (1999)
Mol. Cell. Biol. 19, 8393-8399
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W. Xie, H. Hong, N. N. Yang, R. J. Lin, C. M. Simon, M. R. Stallcup, and R. M. Evans (1999)
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M. K. Mateyak, A. J. Obaya, and J. M. Sedivy (1999)
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J. Biol. Chem. 274, 9098-9107
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Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src.
N. Aziz, H. Cherwinski, and M. McMahon (1999)
Mol. Cell. Biol. 19, 1101-1115
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Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation.
Y. Qyang, X. Luo, T. Lu, P. M. Ismail, D. Krylov, C. Vinson, and M. Sawadogo (1999)
Mol. Cell. Biol. 19, 1508-1517
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A Novel Factor Binding to the Glucose Response Elements of Liver Pyruvate Kinase and Fatty Acid Synthase Genes.
J.-i. Hasegawa, K. Osatomi, R.-F. Wu, and K. Uyeda (1999)
J. Biol. Chem. 274, 1100-1107
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c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism.
C. V. Dang (1999)
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L. E. Sivak, G. Pont-Kingdon, K. Le, G. Mayr, K.-F. Tai, B. T. Stevens, and W. L. Carroll (1999)
Mol. Cell. Biol. 19, 155-163
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myc Boxes, Which Are Conserved in myc Family Proteins, Are Signals for Protein Degradation via the Proteasome.
E. M. Flinn, C. M. C. Busch, and A. P. H. Wright (1998)
Mol. Cell. Biol. 18, 5961-5969
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Multiple Promoter Elements Contribute to Activity of the Follicle-Stimulating Hormone Receptor (FSHR) Gene in Testicular Sertoli Cells.
L. L. Heckert, M. A. F. Daggett, and J. Chen (1998)
Mol. Endocrinol. 12, 1499-1512
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Multiple Promoter Elements Interact to Control the Transcription of the Potassium Channel Gene, KCNJ2.
J. B. Redell and B. L Tempel (1998)
J. Biol. Chem. 273, 22807-22818
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Identification of a New Binding Motif for the Paired Domain of Pax-3 and Unusual Characteristics of Spacing of Bipartite Recognition Elements on Binding and Transcription Activation.
S. A. Phelan and M. R. Loeken (1998)
J. Biol. Chem. 273, 19153-19159
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RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2.
E. Batsché, C. Muchardt, J. Behrens, H. C. Hurst, and C. Crémisi (1998)
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Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice.
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New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.
T. Lagrange, A. N. Kapanidis, H. Tang, D. Reinberg, and R. H. Ebright (1998)
Genes & Dev. 12, 34-44
   Abstract »    Full Text »
Biphasic Regulation of the Preproendothelin-1 Gene by c-myc.
M. Shichiri, S. Adachi, J. M. Sedivy, F. Marumo, and Y. Hirata (1997)
Endocrinology 138, 4584-4590
   Abstract »    Full Text »    PDF »
Rtg3p, a Basic Helix-Loop-Helix/Leucine Zipper Protein that Functions in Mitochondrial-induced Changes in Gene Expression, Contains Independent Activation Domains.
B. A. Rothermel, J. L. Thornton, and R. A. Butow (1997)
J. Biol. Chem. 272, 19801-19807
   Abstract »    Full Text »    PDF »
Distinct Roles for MAX Protein Isoforms in Proliferation and Apoptosis.
H. Zhang, S. Fan, and E. V. Prochownik (1997)
J. Biol. Chem. 272, 17416-17424
   Abstract »    Full Text »    PDF »
The interferon-inducible murine p48 (ISGF3gamma ) gene is regulated by protooncogene c-myc.
X. Weihua, D. J. Lindner, and D. V. Kalvakolanu (1997)
PNAS 94, 7227-7232
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Sertoli Cell Immediate Early Genes by Interleukin-6 and Interferon-{gamma} Is Mediated through Phosphorylation of STAT-3 and STAT-1 Proteins.
S. Jenab and P. L. Morris (1997)
Endocrinology 138, 2740-2746
   Abstract »    Full Text »    PDF »
Regulation of the Nuclear Gene That Encodes the alpha -Subunit of the Mitochondrial F0F1-ATP Synthase Complex. ACTIVATION BY UPSTREAM STIMULATORY FACTOR 2.
G. A.M. Breen and E. M. Jordan (1997)
J. Biol. Chem. 272, 10538-10542
   Abstract »    Full Text »    PDF »
Organization and Regulatory Aspects of the Human Intestinal Mucin Gene (MUC2) Locus.
A. Velcich, L. Palumbo, L. Selleri, G. Evans, and L. Augenlicht (1997)
J. Biol. Chem. 272, 7968-7976
   Abstract »    Full Text »    PDF »
Carbohydrate Regulation of Hepatic Gene Expression. EVIDENCE AGAINST A ROLE FOR THE UPSTREAM STIMULATORY FACTOR.
E. N. Kaytor, H.-m. Shih, and H. C. Towle (1997)
J. Biol. Chem. 272, 7525-7531
   Abstract »    Full Text »    PDF »
Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites..
P J Hurlin, C Queva, and R N Eisenman (1997)
Genes & Dev. 11, 44-58
   Abstract »    PDF »
Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter.
M. M. Magana and T. F. Osborne (1996)
J. Biol. Chem. 271, 32689-32694
   Abstract »    Full Text »    PDF »
Transcription of the Transforming Growth Factor-beta 2 Gene Is Dependent on an E-box Located between an Essential cAMP Response Element/Activating Transcription Factor Motif and the TATA Box of the Gene.
B. Scholtz, M. Kingsley-Kallesen, and A. Rizzino (1996)
J. Biol. Chem. 271, 32375-32380
   Abstract »    Full Text »    PDF »
Retinoic Acid-induced Transcriptional Modulation of the Human Interferon-gamma Promoter.
M. Cippitelli, J. Ye, V. Viggiano, A. Sica, P. Ghosh, A. Gulino, A. Santoni, and H. A. Young (1996)
J. Biol. Chem. 271, 26783-26793
   Abstract »    Full Text »    PDF »
Regulatory Function of Delta/YY-1 on the Locus Control Region-like Sequence of Mouse Glycophorin Gene in Erythroleukemia Cells.
Y. Nemoto, M. Terajima, W. Shoji, and M. Obinata (1996)
J. Biol. Chem. 271, 13542-13548
   Abstract »    Full Text »    PDF »
A Large DNA-binding Nuclear Protein with RNA Recognition Motif and Serine/Arginine-rich Domain.
H. Inagaki, Y. Matsushima, K. Nakamura, M. Ohshima, T. Kadowaki, and Y. Kitagawa (1996)
J. Biol. Chem. 271, 12525-12531
   Abstract »    Full Text »    PDF »
Functional Characterization of Mouse Syndecan-1 Promoter.
T. Vihinen, A. Määttä, P. Jaakkola, P. Auvinen, and M. Jalkanen (1996)
J. Biol. Chem. 271, 12532-12541
   Abstract »    Full Text »    PDF »
Functional Analysis of Burkitt's Lymphoma Mutant c-Myc Proteins.
B. Smith-Sørensen, E. M. Hijmans, R. L. Beijersbergen, and R. Bernards (1996)
J. Biol. Chem. 271, 5513-5518
   Abstract »    Full Text »    PDF »


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