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Science 23 November 1990:
Vol. 250. no. 4984, pp. 1142 - 1147
DOI: 10.1126/science.2174573
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Articles

Science, Vol 250, Issue 4984, 1142-1147
Copyright © 1990 by American Association for the Advancement of Science

articles

Contributions of two types of calcium channels to synaptic transmission and plasticity

B Edmonds, M Klein, N Dale, and ER Kandel

Department of Pharmacology, University College of London, United Kingdom.

In Aplysia sensory and motor neurons in culture, the contributions of the major classes of calcium current can be selectively examined while transmitter release and its modulation are examined. A slowly inactivating, dihydropyridine-sensitive calcium current does not contribute either to normal synaptic transmission or to any of three different forms of plasticity: presynaptic inhibition, homosynaptic depression, and presynaptic facilitation. This current does contribute, however, to a fourth form of plasticity--modulation of transmitter release by tonic depolarization of the sensory neuron. By contrast, a second calcium current, which is rapidly inactivating and dihydropyridine-insensitive, contributes to release elicited by the transient depolarization of an action potential and to the other three forms of plasticity.


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