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Science 23 November 1990: Vol. 250. no. 4984, pp. 1130 - 1132 DOI: 10.1126/science.1701274
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Articles
Science, Vol 250, Issue 4984, 1130-1132
Copyright © 1990 by American Association for the Advancement of Science
ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex
ML Phillips,
E Nudelman,
FC Gaeta,
M Perez,
AK Singhal,
S Hakomori,
and
JC Paulson
Cytel Corp., La Jolla, CA 92037.
Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.
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J. Biol. Chem.
271, 7450-7459
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- Structure-Function Analysis of P-selectin-Sialyl Lewis^X Binding Interactions.
- B. M. Revelle, D. Scott, T. P. Kogan, J. Zheng, and P. J. Beck (1996)
J. Biol. Chem.
271, 4289-4297
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- Gliolectin is a novel carbohydrate-binding protein expressed by a subset of glia in the embryonic Drosophila nervous system.
- M Tiemeyer and C. Goodman (1996)
Development
122, 925-936
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- A Novel Cobra Venom Metalloproteinase, Mocarhagin, Cleaves a 10-Amino Acid Peptide from the Mature N Terminus of P-selectin Glycoprotein Ligand Receptor, PSGL-1, and Abolishes P-selectin Binding.
- M. De Luca, L. C. Dunlop, R. K. Andrews, J. V. Flannery , Jr., R. Ettling, D. A. Cumming, G. M. Veldman, and M. C. Berndt (1995)
J. Biol. Chem.
270, 26734-26737
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- Sepsis-Induced Acute Lung Injury Is Attenuated by Selectin Blockade Following the Onset of Sepsis.
- P. C. Ridings, G. L. Bloomfield, S. Holloway, A. C. J. Windsor, M. A. Jutila, A. A. Fowler III, and H. J. Sugerman (1995)
Arch Surg
130, 1199-1208
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- Molecular Cloning, Expression, Chromosomal Assignment, and Tissue-specific Expression of a Murine alpha-(1,3)-Fucosyltransferase Locus Corresponding to the Human ELAM-1 Ligand Fucosyl Transferase.
- K. M. Gersten, S. Natsuka, M. Trinchera, B. Petryniak, R. J. Kelly, N. Hiraiwa, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and J. B. Lowe (1995)
J. Biol. Chem.
270, 25047-25056
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- Structural Analysis of the Oligosaccharides Derived from Glycodelin, a Human Glycoprotein with Potent Immunosuppressive and Contraceptive Activities.
- A. Dell, H. R. Morris, R. L. Easton, M. Panico, M. Patankar, S. Oehninger, R. Koistinen, H. Koistinen, M. Seppala, and G. F. Clark (1995)
J. Biol. Chem.
270, 24116-24126
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- Human alpha(1,3/1,4)-Fucosyltransferases Discriminate between Different Oligosaccharide Acceptor Substrates through a Discrete Peptide Fragment.
- D. J. Legault, R. J. Kelly, Y. Natsuka, and J. B. Lowe (1995)
J. Biol. Chem.
270, 20987-20996
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- Peptides Which Bind to E-selectin and Block Neutrophil Adhesion.
- C. L. Martens, S. E. Cwirla, R. Y.-W. Lee, E. Whitehorn, E. Y.-F. Chen, A. Bakker, E. L. Martin, C. Wagstrom, P. Gopalan, C. W. Smith, et al. (1995)
J. Biol. Chem.
270, 21129-21136
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- Adjunctive Selectin Blockade Successfully Reduces Infarct Size Beyond Thrombolysis in the Electrolytic Canine Coronary Artery Model.
- M. J. Silver, J. M. Sutton, S. Hook, P. Lee, J. L. Malycky, M. L. Phillips, S. G. Ellis, E. J. Topol, and F. A. Nicolini (1995)
Circulation
92, 492-499
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- Calcium-dependent Conformation of a Mouse Macrophage Calcium-type Lectin.
- T. Kimura, Y. Imai, and T. Irimura (1995)
J. Biol. Chem.
270, 16056-16062
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- Sialyllactose-mediated Cell Interaction during Granulosa Cell Differentiation.
- M.-a. Hattori, R. Horiuchi, K. Hosaka, H. Hayashi, and I. Kojima (1995)
J. Biol. Chem.
270, 7858-7863
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- Expression of Lewis-Related Antigen and Prognosis in Stage I Non-Small Cell Lung Cancer.
- J.-i. Ogawa, A. Sano, H. Inoue, and S. Koide (1995)
Ann. Thorac. Surg.
59, 412-415
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- Relation between recurrence and expression of proliferating cell nuclear antigen, sialyl Lewis X, and sialyl Lewis a in lung cancer.
- J.-i. Ogawa, A. Sano, S. Koide, and A. Shohtsu (1994)
J. Thorac. Cardiovasc. Surg.
108, 329-336
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- Cell Adhesion Molecules in Inflammation and Immunity: Relevance to Periodontal Diseases.
- J. M. Crawford and K. Watanabe (1994)
Critical Reviews in Oral Biology & Medicine
5, 91-123
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- Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells.
- K. Norgard-Sumnicht, N. Varki, and A Varki (1993)
Science
261, 480-483
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- Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family..
- M F Bierhuizen, M G Mattei, and M Fukuda (1993)
Genes & Dev.
7, 468-478
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- Selectins: interpreters of cell-specific carbohydrate information during inflammation.
- L. Lasky (1992)
Science
258, 964-969
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- Occurrence of sialic acids in Drosophila melanogaster.
- J Roth, A Kempf, G Reuter, R Schauer, and W. Gehring (1992)
Science
256, 673-675
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- Glycosylation-dependent Cell Adhesion Molecule 1: A Novel Mucin-like Adhesion Ligand for L-Selectin.
- L.A. Lasky, M.S. Singer, D. Dowbenko, Y. Imai, W. Henzel, C. Fennie, S. Watson, and S.D. Rosen (1992)
Cold Spring Harb Symp Quant Biol
57, 259-269
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- Quantitative Determination of Selectin-Carbohydrate Interactions.
- R.M. Nelson, A. Aruffo, S. Dolich, O. Cecconi, G. Mannori, and M.P. Bevilacqua (1992)
Cold Spring Harb Symp Quant Biol
57, 271-279
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- Lymphocyte Homing Receptors.
- M.C.-T. Hu, M.H. Siegelman, B. Holzmann, D.T. Crowe, and I.L. Weissman (1992)
Cold Spring Harb Symp Quant Biol
57, 291-308
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- Pregnancy-associated Changes in the Glycosylation of Tamm-Horsfall Glycoprotein. EXPRESSION OF SIALYL LEWISx SEQUENCES ON CORE 2 TYPE O-GLYCANS DERIVED FROM UROMODULIN.
- R. L. Easton, M. S. Patankar, G. F. Clark, H. R. Morris, and A. Dell (2000)
J. Biol. Chem.
275, 21928-21938
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- Identification and Characterization of Three Novel beta 1,3-N-Acetylglucosaminyltransferases Structurally Related to the beta 1,3-Galactosyltransferase Family.
- N. Shiraishi, A. Natsume, A. Togayachi, T. Endo, T. Akashima, Y. Yamada, N. Imai, S. Nakagawa, S. Koizumi, S. Sekine, et al. (2001)
J. Biol. Chem.
276, 3498-3507
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- Soluble E-selectin Induces Monocyte Chemotaxis through Src Family Tyrosine Kinases.
- P. Kumar, S. Hosaka, and A. E. Koch (2001)
J. Biol. Chem.
276, 21039-21045
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- Inaugural Article: The glycosynapse.
- S.-i. Hakomori (2002)
PNAS
99, 225-232
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