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Science 23 November 1990:
Vol. 250. no. 4984, pp. 1130 - 1132
DOI: 10.1126/science.1701274

Articles

Science, Vol 250, Issue 4984, 1130-1132
Copyright © 1990 by American Association for the Advancement of Science


articles

ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex

ML Phillips, E Nudelman, FC Gaeta, M Perez, AK Singhal, S Hakomori, and JC Paulson

Cytel Corp., La Jolla, CA 92037.

Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.


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   Abstract »    Full Text »    PDF »
Peptides Which Bind to E-selectin and Block Neutrophil Adhesion.
C. L. Martens, S. E. Cwirla, R. Y.-W. Lee, E. Whitehorn, E. Y.-F. Chen, A. Bakker, E. L. Martin, C. Wagstrom, P. Gopalan, C. W. Smith, et al. (1995)
J. Biol. Chem. 270, 21129-21136
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Adjunctive Selectin Blockade Successfully Reduces Infarct Size Beyond Thrombolysis in the Electrolytic Canine Coronary Artery Model.
M. J. Silver, J. M. Sutton, S. Hook, P. Lee, J. L. Malycky, M. L. Phillips, S. G. Ellis, E. J. Topol, and F. A. Nicolini (1995)
Circulation 92, 492-499
   Abstract »    Full Text »
Calcium-dependent Conformation of a Mouse Macrophage Calcium-type Lectin.
T. Kimura, Y. Imai, and T. Irimura (1995)
J. Biol. Chem. 270, 16056-16062
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Sialyllactose-mediated Cell Interaction during Granulosa Cell Differentiation.
M.-a. Hattori, R. Horiuchi, K. Hosaka, H. Hayashi, and I. Kojima (1995)
J. Biol. Chem. 270, 7858-7863
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Expression of Lewis-Related Antigen and Prognosis in Stage I Non-Small Cell Lung Cancer.
J.-i. Ogawa, A. Sano, H. Inoue, and S. Koide (1995)
Ann. Thorac. Surg. 59, 412-415
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Relation between recurrence and expression of proliferating cell nuclear antigen, sialyl Lewis X, and sialyl Lewis a in lung cancer.
J.-i. Ogawa, A. Sano, S. Koide, and A. Shohtsu (1994)
J. Thorac. Cardiovasc. Surg. 108, 329-336
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Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells.
K. Norgard-Sumnicht, N. Varki, and A Varki (1993)
Science 261, 480-483
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Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family..
M F Bierhuizen, M G Mattei, and M Fukuda (1993)
Genes & Dev. 7, 468-478
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Selectins: interpreters of cell-specific carbohydrate information during inflammation.
L. Lasky (1992)
Science 258, 964-969
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Occurrence of sialic acids in Drosophila melanogaster.
J Roth, A Kempf, G Reuter, R Schauer, and W. Gehring (1992)
Science 256, 673-675
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Pregnancy-associated Changes in the Glycosylation of Tamm-Horsfall Glycoprotein. EXPRESSION OF SIALYL LEWISx SEQUENCES ON CORE 2 TYPE O-GLYCANS DERIVED FROM UROMODULIN.
R. L. Easton, M. S. Patankar, G. F. Clark, H. R. Morris, and A. Dell (2000)
J. Biol. Chem. 275, 21928-21938
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Identification and Characterization of Three Novel beta 1,3-N-Acetylglucosaminyltransferases Structurally Related to the beta 1,3-Galactosyltransferase Family.
N. Shiraishi, A. Natsume, A. Togayachi, T. Endo, T. Akashima, Y. Yamada, N. Imai, S. Nakagawa, S. Koizumi, S. Sekine, et al. (2001)
J. Biol. Chem. 276, 3498-3507
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Soluble E-selectin Induces Monocyte Chemotaxis through Src Family Tyrosine Kinases.