Related Content
Search Google Scholar for:
|
|
Science 23 November 1990:
Vol. 250. no. 4984, pp. 1127 - 1129
DOI: 10.1126/science.1701273
|
|
Articles
Science, Vol 250, Issue 4984, 1127-1129
Copyright © 1990 by American Association for the Advancement of Science
Detection of a human intracisternal A-type retroviral particle antigenically related to HIV
RF Garry,
CD Fermin,
DJ Hart,
SS Alexander,
LA Donehower,
and
H Luo-Zhang
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112.
Sjogren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenically related to HIV was detected in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease.
- C. Voisset, R. A. Weiss, and D. J. Griffiths (2008)
Microbiol. Mol. Biol. Rev.
72, 157-196
| Abstract »
| Full Text »
| PDF »
- The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study.
- H D Ejtehadi, G L Freimanis, H A Ali, S Bowman, A Alavi, J Axford, R Callaghan, and P N Nelson (2006)
Ann Rheum Dis
65, 612-616
| Abstract »
| Full Text »
| PDF »
- Lamivudine is not effective in primary Sjogren's syndrome.
- B Gescuk, A J Wu, J P Whitcher, T E Daniels, S Lund, K Fye, and J C Davis Jr (2005)
Ann Rheum Dis
64, 1326-1330
| Abstract »
| Full Text »
| PDF »
- Demystified . . . Human endogenous retroviruses.
- P N Nelson, P R Carnegie, J Martin, H Davari Ejtehadi, P Hooley, D Roden, S Rowland-Jones, P Warren, J Astley, and P G Murray (2003)
Mol. Pathol.
56, 11-18
| Abstract »
| Full Text »
| PDF »
- Viruses and Diabetes.
- E. JAECKEL, M. MANNS, and M. VON HERRATH (2002)
Ann. N.Y. Acad. Sci.
958, 7-25
| Abstract »
| Full Text »
| PDF »
- Possible Involvement of EBV-Mediated {{alpha}}-Fodrin Cleavage for Organ-Specific Autoantigen in Sjogren's Syndrome.
- H. Inoue, K. Tsubota, M. Ono, Y. Kizu, F. Mizuno, K. Takada, K. Yamada, K. Yanagi, Y. Hayashi, and I. Saito (2001)
J. Immunol.
166, 5801-5809
| Abstract »
| Full Text »
| PDF »
- Familial erosive arthritis associated with seroreactivity to human intracisternal retroviral particle type I (HIAP-I).
- E. A. Mendez, K. B. DeSalvo, Y. Cao, R. F. Garry, and L. R. Espinoza (2001)
Rheumatology
40, 227-228
| Full Text »
| PDF »
- PBC: an infectious disease?.
- G H HAYDON and J NEUBERGER (2000)
Gut
47, 586-588
| Full Text »
| PDF »
- Fas Ligand-Mediated Exocrinopathy Resembling Sjogren's Syndrome in Mice Transgenic for IL-10.
- I. Saito, K. Haruta, M. Shimuta, H. Inoue, H. Sakurai, K. Yamada, N. Ishimaru, H. Higashiyama, T. Sumida, H. Ishida, et al. (1999)
J. Immunol.
162, 2488-2494
| Abstract »
| Full Text »
| PDF »
- Reactivity of Sera from Systemic Lupus Erythematosus and Sjogren's Syndrome Patients with Peptides Derived from Human Immunodeficiency Virus p24 Capsid Antigen.
- J. E. Deas, L. G. Liu, J. J. Thompson, D. M. Sander, S. S. Soble, R. F. Garry, and W. R. Gallaher (1998)
Clin. Vaccine Immunol.
5, 181-185
| Abstract »
| Full Text »
- Immunopathology of Sjogren's Syndrome: More Questions than Answers.
- H.M. Moutsopoulos (1993)
Lupus
2, 209-211
| PDF »
- 'Mystery' Virus Meets the Skeptics: At a hastily called meeting in Atlanta, 300 researchers heard about AIDS-like illnesses without HIV. The evidence for new viruses is, to put it mildly, sketchy.
- J. Cohen (1992)
Science
257, 1032-1034
| PDF »
- SJOGREN'S SYNDROME MAY BE CAUSED BY A RETROVIRUS.
- (1990)
Journal Watch (General)
1990, 5
| Full Text »
|
|
