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Science 23 November 1990:
Vol. 250. no. 4984, pp. 1127 - 1129
DOI: 10.1126/science.1701273
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Articles

Science, Vol 250, Issue 4984, 1127-1129
Copyright © 1990 by American Association for the Advancement of Science

articles

Detection of a human intracisternal A-type retroviral particle antigenically related to HIV

RF Garry, CD Fermin, DJ Hart, SS Alexander, LA Donehower, and H Luo-Zhang

Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112.

Sjogren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenically related to HIV was detected in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.


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