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Science 23 November 1990:
Vol. 250. no. 4984, pp. 1104 - 1110
DOI: 10.1126/science.2174572
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Articles

Science, Vol 250, Issue 4984, 1104-1110
Copyright © 1990 by American Association for the Advancement of Science

articles

Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection

TK Blackwell and H Weintraub

Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, WA.

A technique was developed for studying protein-DNA recognition that can be applied to any purified protein, partially purified protein, or cloned gene. From oligonucleotides in which particular positions are of random sequence, that subset to which a given protein binds is amplified by the polymerase chain reaction and sequenced as a pool. These selected and amplified binding site (SAAB) "imprints" provide a characteristic set of preferred sequences for protein binding. With this technique, it was shown that homo- and heterooligomers of the helix-loop-helix proteins MyoD and E2A recognize a common consensus sequence, CA--TG, but otherwise bind to flanking and internal positions with different sequence preferences that suggest half-site recognition. These findings suggest that different combinations of dimeric proteins can have different binding sequence preferences.


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Derivation and Functional Characterization of a Consensus DNA Binding Sequence for the Tas Transcriptional Activator of Simian Foamy Virus Type 1.
Y. Kang and B. R. Cullen (1998)
J. Virol. 72, 5502-5509
   Abstract »    Full Text »    PDF »
In Vitro Genetic Analysis of the RNA Binding Site of Vigilin, a Multi-KH-Domain Protein.
H. Kanamori, R. E. Dodson, and D. J. Shapiro (1998)
Mol. Cell. Biol. 18, 3991-4003
   Abstract »    Full Text »
Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes.
M. E. Massari, R. R. Rivera, J. R. Voland, M. W Quong, T. M. Breit, J. J. M. van Dongen, O. de Smit, and C. Murre (1998)
Mol. Cell. Biol. 18, 3130-3139
   Abstract »    Full Text »
The E Protein CTF4 and Acetylcholine Receptor Expression in Development and Denervation Supersensitivity.
C. M. Neville, Y.-H. Choe, Y.-S. Lee, D. Spinner, H.-J. Tsay, and J. Schmidt (1998)
J. Biol. Chem. 273, 14046-14052
   Abstract »    Full Text »    PDF »
Molecular Cloning, Characterization, and Promoter Analysis of the Mouse Crp2/SmLim Gene. PREFERENTIAL EXPRESSION OF ITS PROMOTER IN THE VASCULAR SMOOTH MUSCLE CELLS OF TRANSGENIC MICE.
S.-F. Yet, S. C. Folta, M. K. Jain, C.-M. Hsieh, K. Maemura, M. D. Layne, D. Zhang, P. B. Marria, M. Yoshizumi, M. T. Chin, et al. (1998)
J. Biol. Chem. 273, 10530-10537
   Abstract »    Full Text »    PDF »
Differentiation-Specific, Octamer-Dependent Costimulation of {kappa} Transcription.
D. Liberg, M. Sigvardsson, M. Bemark, and T. Leanderson (1998)
J. Immunol. 160, 3899-3907
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Human Nonmuscle Myosin II Heavy Chain-A Gene. IDENTIFICATION OF THREE CLUSTERED CIS-ELEMENTS IN INTRON-1 WHICH MODULATE TRANSCRIPTION IN A CELL TYPE- AND DIFFERENTIATION STATE-DEPENDENT MANNER.
N. Beohar and S. Kawamoto (1998)
J. Biol. Chem. 273, 9168-9178
   Abstract »    Full Text »    PDF »
A Novel Site, Mt, in the Human Desmin Enhancer Is Necessary for Maximal Expression in Skeletal Muscle.
J. Gao, Z. Li, and D. Paulin (1998)
J. Biol. Chem. 273, 6402-6409
   Abstract »    Full Text »    PDF »


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