Related Content
Search Google Scholar for:
|
|
Science 16 November 1990:
Vol. 250. no. 4983, pp. 994 - 997
DOI: 10.1126/science.2173146
|
|
Articles
Science, Vol 250, Issue 4983, 994-997
Copyright © 1990 by American Association for the Advancement of Science
Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts
L Bonetta,
SE Kuehn,
A Huang,
DJ Law,
LM Kalikin,
M Koi,
AE Reeve,
BH Brownstein,
H Yeger,
BR Williams,
and
al. et
Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada.
Wilms tumor is an embryonal kidney tumor involving complex pathology and genetics. The Wilms tumor locus on chromosome 11p13 is defined by the region of overlap of constitutional and tumor-associated deletions. Chromosome walking and yeast artificial chromosome (YAC) cloning were used to clone and map 850 kilobases of DNA. Nine CpG islands, constituting a "CpG island archipelago," were identified, including three islands that were not apparent by conventional pulsed-field mapping, and thus were at least partially methylated. Three distinct transcriptional units were found closely associated with a CpG island within the boundaries of a homozygous DNA deletion in a Wilms tumor.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- The Wilms' Tumor Suppressor Wt1 Is Associated with the Differentiation of Retinoblastoma Cells.
- N. Wagner, K.-D. Wagner, G. Schley, S. E. Coupland, H. Heimann, R. Grantyn, and H. Scholz (2002)
Cell Growth Differ.
13, 297-305
| Abstract »
| Full Text »
- A Far Upstream Cis-element Is Required for Wilms' Tumor-1 (WT1) Gene Expression in Renal Cell Culture.
- H. Scholz, S. A. Bossone, H. T. Cohen, U. Akella, W. M. Strauss, and V. P. Sukhatme (1997)
J. Biol. Chem.
272, 32836-32846
| Abstract »
| Full Text »
| PDF »
- Sp1 Is a Critical Regulator of the Wilms' tumor-1 Gene.
- H. T. Cohen, S. A. Bossone, G. Zhu, G. A. McDonald, and V. P. Sukhatme (1997)
J. Biol. Chem.
272, 2901-2913
| Abstract »
| Full Text »
| PDF »
- Genetic Events in the Development of Wilms' Tumor.
- M. J. Coppes, D. A. Haber, and P. E. Grundy (1994)
N. Engl. J. Med.
331, 586-590
| Full Text »
- Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11.
- M Koi, L. Johnson, L. Kalikin, P. Little, Y Nakamura, and A. Feinberg (1993)
Science
260, 361-364
| Abstract »
| PDF »
- Chromosome aberrations and cancer.
- E Solomon, J Borrow, and A. Goddard (1991)
Science
254, 1153-1160
| Abstract »
| PDF »
- Sequence-tagged site (STS) content mapping of human chromosomes: theoretical considerations and early experiences..
- E D Green and P Green (1991)
Genome Res.
1, 77-90
| Abstract »
| PDF »
- Molecular basis of mouse developmental mutants..
- A D Reith and A Bernstein (1991)
Genes & Dev.
5, 1115-1123
| PDF »
- Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor.
- A Huang, C. Campbell, L Bonetta, M. McAndrews-Hill, S Chilton-MacNeill, M. Coppes, D. Law, A. Feinberg, H Yeger, and B. Williams (1990)
Science
250, 991-994
| Abstract »
| PDF »
- Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation.
- P. Stanhope-Baker and B. R. G. Williams (2000)
J. Biol. Chem.
275, 38139-38150
| Abstract »
| Full Text »
| PDF »
|
|
