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Science 9 November 1990: Vol. 250. no. 4982, pp. 830 - 832 DOI: 10.1126/science.2173142
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Articles
Science, Vol 250, Issue 4982, 830-832
Copyright © 1990 by American Association for the Advancement of Science
Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1
DH Hsu,
R de Waal Malefyt,
DF Fiorentino,
MN Dang,
P Vieira,
J de Vries,
H Spits,
TR Mosmann,
and
KW Moore
Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.
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