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Science 9 November 1990:
Vol. 250. no. 4982, pp. 830 - 832
DOI: 10.1126/science.2173142

Articles

Science, Vol 250, Issue 4982, 830-832
Copyright © 1990 by American Association for the Advancement of Science


articles

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

DH Hsu, R de Waal Malefyt, DF Fiorentino, MN Dang, P Vieira, J de Vries, H Spits, TR Mosmann, and KW Moore

Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)