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Science 9 November 1990:
Vol. 250. no. 4982, pp. 800 - 802
DOI: 10.1126/science.1978411
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Articles

Science, Vol 250, Issue 4982, 800-802
Copyright © 1990 by American Association for the Advancement of Science

articles

Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus

A Hemmati-Brivanlou, RM Stewart, and RM Harland

Department of Molecular and Cellular Biology, University of California, Berkeley 94720.

Anterior-specific neural induction can be assayed by means of an antibody that recognizes the Xenopus homeobox-containing protein En-2. The En-2 antigen is an excellent early marker, since it is present as a discrete band in the anterior neural plate of neurula embryos. Regional induction was assayed by combining dorsal mesoderm with competent ectoderm. Anterior notochord from the early neurula induced En-2 frequently, while posterior notochord induced En-2 less frequently. Presumptive somitic mesoderm and presumptive head mesoderm, though they induced neural tissue, were not strong inducers of En-2. Thus, anterior notochord may be the primary mesodermal tissue responsible for the patterning of the anterior neural plate.


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