Science 26 October 1990: Vol. 250. no. 4980, pp. 553 - 556 DOI: 10.1126/science.2237407

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Articles

Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis.

U. Pal, P. Wang, F. Bao, X. Yang, S. Samanta, R. Schoen, G. P. Wormser, I. Schwartz, and E. Fikrig (2008)
J. Exp. Med. 205, 133-141
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Lyme Arthritis: Current Concepts and a Change in Paradigm.

D. T. Nardelli, S. M. Callister, and R. F. Schell (2008)
Clin. Vaccine Immunol. 15, 21-34
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Prostaglandin E2 Is a Major Inhibitor of Dendritic Cell Maturation and Function in Ixodes scapularis Saliva.

A. Sa-Nunes, A. Bafica, D. A. Lucas, T. P. Conrads, T. D. Veenstra, J. F. Andersen, T. N. Mather, J. M. C. Ribeiro, and I. M. B. Francischetti (2007)
J. Immunol. 179, 1497-1505
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Constitutive Expression of Outer Surface Protein C Diminishes the Ability of Borrelia burgdorferi To Evade Specific Humoral Immunity.

Q. Xu, S. V. Seemanapalli, K. McShan, and F. T. Liang (2006)
Infect. Immun. 74, 5177-5184
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A Database of Bacterial Lipoproteins (DOLOP) with Functional Assignments to Predicted Lipoproteins..

M. M. Babu, M. L. Priya, A. T. Selvan, M. Madera, J. Gough, L. Aravind, and K. Sankaran (2006)
J. Bacteriol. 188, 2761-2773
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Interleukin-6 Promotes Anti-OspA Borreliacidal Antibody Production In Vitro.

E. L. Munson, D. T. Nardelli, K. H. K. Luk, M. C. Remington, S. M. Callister, and R. F. Schell (2006)
Clin. Vaccine Immunol. 13, 19-25
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Borrelia burgdorferi Regulates Expression of Complement Regulator-Acquiring Surface Protein 1 during the Mammal-Tick Infection Cycle.

K. von Lackum, J. C. Miller, T. Bykowski, S. P. Riley, M. E. Woodman, V. Brade, P. Kraiczy, B. Stevenson, and R. Wallich (2005)
Infect. Immun. 73, 7398-7405
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A Small Molecule {alpha}4{beta}1 Antagonist Prevents Development of Murine Lyme Arthritis without Affecting Protective Immunity.

J. Glasner, H. Blum, V. Wehner, H. U. Stilz, J. D. Humphries, G. P. Curley, A. P. Mould, M. J. Humphries, R. Hallmann, M. Rollinghoff, et al. (2005)
J. Immunol. 175, 4724-4734
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The Calcium-binding Protein S100A2 Interacts with p53 and Modulates Its Transcriptional Activity.

A. Mueller, B. W. Schafer, S. Ferrari, M. Weibel, M. Makek, M. Hochli, and C. W. Heizmann (2005)
J. Biol. Chem. 280, 29186-29193
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Interactions of OspA Monoclonal Antibody C3.78 with Borrelia burgdorferi within Ticks.

C. L. Gipson and A. M. de Silva (2005)
Infect. Immun. 73, 1644-1647
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Evidence of Borrelia Autoimmunity-Induced Component of Lyme Carditis and Arthritis.

E. S. Raveche, S. E. Schutzer, H. Fernandes, H. Bateman, B. A. McCarthy, S. P. Nickell, and M. W. Cunningham (2005)
J. Clin. Microbiol. 43, 850-856
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Relative Contributions of Innate and Acquired Host Responses to Bacterial Control and Arthritis Development in Lyme Disease.

X. Wang, Y. Ma, J. H. Weis, J. F. Zachary, C. J. Kirschning, and J. J. Weis (2005)
Infect. Immun. 73, 657-660
 |  Abstract »  |  Full Text »  |  PDF »

Protective Niche for Borrelia burgdorferi to Evade Humoral Immunity.

F. T. Liang, E. L. Brown, T. Wang, R. V. Iozzo, and E. Fikrig (2004)
Am. J. Pathol. 165, 977-985
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Whole-Genome DNA Array Analysis of the Response of Borrelia burgdorferi to a Bactericidal Monoclonal Antibody.

J. M. Anderton, R. Tokarz, C. D. Thill, C. J. Kuhlow, C. S. Brooks, D. R. Akins, L. I. Katona, and J. L. Benach (2004)
Infect. Immun. 72, 2035-2044
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Borrelia Outer Membrane Surface Proteins and Transmission Through the Tick.

T. J. Templeton (2004)
J. Exp. Med. 199, 603-606
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Neutralization of Gamma Interferon Augments Borreliacidal Antibody Production and Severe Destructive Lyme Arthritis in C3H/HeJ Mice.

E. L. Munson, D. J. DeCoster, D. T. Nardelli, D. M. England, S. M. Callister, and R. F. Schell (2004)
Clin. Vaccine Immunol. 11, 35-41
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Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein.

S. Feng, E. Hodzic, K. Freet, and S. W. Barthold (2003)
Infect. Immun. 71, 7211-7214
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Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi.

R. D. Gilmore Jr, R. M. Bacon, A. M. Carpio, J. Piesman, M. C. Dolan, and M. L. Mbow (2003)
J. Med. Microbiol. 52, 551-556
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Gamma Interferon Inhibits Production of Anti-OspA Borreliacidal Antibody In Vitro.

E. L. Munson, B. K. Du Chateau, J. R. Jensen, S. M. Callister, D. J. DeCoster, and R. F. Schell (2002)
Clin. Vaccine Immunol. 9, 1095-1101
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody.

U. Pal, R. R. Montgomery, D. Lusitani, P. Voet, V. Weynants, S. E. Malawista, Y. Lobet, and E. Fikrig (2001)
J. Immunol. 166, 7398-7403
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Major Histocompatibility Complex Class II-Independent Generation of Neutralizing Antibodies against T-Cell-Dependent Borrelia burgdorferi Antigens Presented by Dendritic Cells: Regulation by NK and {gamma}{delta} T Cells.

M. L. Mbow, N. Zeidner, R. D. Gilmore Jr., M. Dolan, J. Piesman, and R. G. Titus (2001)
Infect. Immun. 69, 2407-2415
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Lyme Borreliosis in Rhesus Macaques: Effects of Corticosteroids on Spirochetal Load and Isotype Switching of Anti-Borrelia burgdorferi Antibody.

A. R. Pachner, K. Amemiya, M. Bartlett, H. Schaefer, K. Reddy, and W.-F. Zhang (2001)
Clin. Vaccine Immunol. 8, 225-232
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C-Terminal Invariable Domain of VlsE May Not Serve as Target for Protective Immune Response against Borrelia burgdorferi.

F. T. Liang, M. B. Jacobs, and M. T. Philipp (2001)
Infect. Immun. 69, 1337-1343
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VraA (BBI16) Protein of Borrelia burgdorferi Is a Surface-Exposed Antigen with a Repetitive Motif That Confers Partial Protection against Experimental Lyme Borreliosis.

M. Labandeira-Rey, E. A. Baker, and J. T. Skare (2001)
Infect. Immun. 69, 1409-1419
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In Vitro and In Vivo Neutralization of the Relapsing Fever Agent Borrelia hermsii with Serotype-Specific Immunoglobulin M Antibodies.

A. G. Barbour and V. Bundoc (2001)
Infect. Immun. 69, 1009-1015
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Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks.

J. Ohnishi, J. Piesman, and A. M. de Silva (2001)
PNAS 98, 670-675
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Production of Borreliacidal Antibody to Outer Surface Protein A In Vitro and Modulation by Interleukin-4.

E. L. Munson, B. K. Du Chateau, D. A. Jobe, S. D. Lovrich, S. M. Callister, and R. F. Schell (2000)
Infect. Immun. 68, 5496-5501
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Identification of Group B Streptococcal Sip Protein, Which Elicits Cross-Protective Immunity.

B. R. Brodeur, M. Boyer, I. Charlebois, J. Hamel, F. Couture, C. R. Rioux, and D. Martin (2000)
Infect. Immun. 68, 5610-5618
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Borreliacidal activity of early Lyme disease sera against complement-resistant Borrelia afzelii FEM1 wild-type and an OspC-lacking FEM1 variant.

P. KRAICZY, K.-P. HUNFELD, S. PETERS, R. WURZNER, G. ACKER, B. WILSKE, and V. BRADE (2000)
J. Med. Microbiol. 49, 917-928
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Comparison of Protection in Rabbits against Host-Adapted and Cultivated Borrelia burgdorferi following Infection-Derived Immunity or Immunization with Outer Membrane Vesicles or Outer Surface Protein A.

E. S. Shang, C. I. Champion, X.-Y. Wu, J. T. Skare, D. R. Blanco, J. N. Miller, and M. A. Lovett (2000)
Infect. Immun. 68, 4189-4199
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Spirochaetal lipoproteins and pathogenesis.

D. A. Haake (2000)
Microbiology 146, 1491-1504
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Arthropod- and Host-Specific Borrelia burgdorferi bbk32 Expression and the Inhibition of Spirochete Transmission.

E. Fikrig, W. Feng, S. W. Barthold, S. R. Telford III, and R. A. Flavell (2000)
J. Immunol. 164, 5344-5351
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Geographic clustering of an outer surface protein A mutant of Borrelia burgdorferi. Possible implications of multiple variants for Lyme disease persistence.

S. E. Malawista, R. R. Montgomery, X.-M. Wang, L. L. Fu, and S. S. Giles (2000)
Rheumatology 39, 537-541
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The Lyme Disease Vaccine: Conception, Development, and Implementation.

W. T. Thanassi and R. T. Schoen (2000)
Ann Intern Med 132, 661-668
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Lyme Disease.

Committee on Infectious Diseases (2000)
Pediatrics 105, 142-147
 |  Abstract »  |  Full Text »  |  PDF »

Leptospiral Outer Membrane Proteins OmpL1 and LipL41 Exhibit Synergistic Immunoprotection.

D. A. Haake, M. K. Mazel, A. M. McCoy, F. Milward, G. Chao, J. Matsunaga, and E. A. Wagar (1999)
Infect. Immun. 67, 6572-6582
 |  Abstract »  |  Full Text »  |  PDF »

Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products.

E. Lien, T. J. Sellati, A. Yoshimura, T. H. Flo, G. Rawadi, R. W. Finberg, J. D. Carroll, T. Espevik, R. R. Ingalls, J. D. Radolf, et al. (1999)
J. Biol. Chem. 274, 33419-33425
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Typing of Borrelia burgdorferi Sensu Lato: Taxonomic, Epidemiological, and Clinical Implications.

G. Wang, A. P. van Dam, I. Schwartz, and J. Dankert (1999)
Clin. Microbiol. Rev. 12, 633-653
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Analysis and Immunological Characterization of the Borrelia Bdr Protein Family.

W. R. Zuckert, J. Meyer, and A. G. Barbour (1999)
Infect. Immun. 67, 3257-3266
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Access of Antibody or Trypsin to an Integral Outer Membrane Protein (P66) of Borrelia burgdorferi Is Hindered by Osp Lipoproteins.

J. Bunikis and A. G. Barbour (1999)
Infect. Immun. 67, 2874-2883
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Influence of Outer Surface Protein A Antibody on Borrelia burgdorferi within Feeding Ticks.

A. M. de Silva, N. S. Zeidner, Y. Zhang, M. C. Dolan, J. Piesman, and E. Fikrig (1999)
Infect. Immun. 67, 30-35
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Specificity of Infection-Induced Immunity among Borrelia burgdorferi Sensu Lato Species.

S. W. Barthold (1999)
Infect. Immun. 67, 36-42
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The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis.

E. Akin, G. L. McHugh, R. A. Flavell, E. Fikrig, and A. C. Steere (1999)
Infect. Immun. 67, 173-181
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Molecular Analysis of Sequence Heterogeneity among Genes Encoding Decorin Binding Proteins A and B of Borrelia burgdorferi Sensu Lato.

W. C. Roberts, B. A. Mullikin, R. Lathigra, and M. S. Hanson (1998)
Infect. Immun. 66, 5275-5285
 |  Abstract »  |  Full Text »  |  PDF »

DbpA, but Not OspA, Is Expressed by Borrelia burgdorferi during Spirochetemia and Is a Target for Protective Antibodies.

D. R. Cassatt, N. K. Patel, N. D. Ulbrandt, and M. S. Hanson (1998)
Infect. Immun. 66, 5379-5387
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant.

A. C. Steere, V. K. Sikand, F. Meurice, D. L. Parenti, E. Fikrig, R. T. Schoen, J. Nowakowski, C. H. Schmid, S. Laukamp, C. Buscarino, et al. (1998)
N. Engl. J. Med. 339, 209-215
 |  Abstract »  |  Full Text »  |  PDF »

A Vaccine Consisting of Recombinant Borrelia burgdorferi Outer-Surface Protein A to Prevent Lyme Disease.

L. H. Sigal, J. M. Zahradnik, P. Lavin, S. J. Patella, G. Bryant, R. Haselby, E. Hilton, M. Kunkel, D. Adler-Klein, T. Doherty, et al. (1998)
N. Engl. J. Med. 339, 216-222
 |  Abstract »  |  Full Text »  |  PDF »

Decorin-Binding Protein of Borrelia burgdorferi Is Encoded within a Two-Gene Operon and Is Protective in the Murine Model of Lyme Borreliosis.

K. E. Hagman, P. Lahdenne, T. G. Popova, S. F. Porcella, D. R. Akins, J. D. Radolf, and M. V. Norgard (1998)
Infect. Immun. 66, 2674-2683
 |  Abstract »  |  Full Text »  |  PDF »

Humoral Immunity to Borrelia burgdorferi N40 Decorin Binding Proteins during Infection of Laboratory Mice.

S. Feng, E. Hodzic, B. Stevenson, and S. W. Barthold (1998)
Infect. Immun. 66, 2827-2835
 |  Abstract »  |  Full Text »  |  PDF »

Active and Passive Immunity against Borrelia burgdorferi Decorin Binding Protein A (DbpA) Protects against Infection.

M. S. Hanson, D. R. Cassatt, B. P. Guo, N. K. Patel, M. P. McCarthy, D. W. Dorward, and M. Hook (1998)
Infect. Immun. 66, 2143-2153
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of the Production of Anti-OspA Borreliacidal Antibody with T Cells from Hamsters Vaccinated against Borrelia burgdorferi.

J. R. Jensen, B. K. Du Chateau, E. L. Munson, S. M. Callister, and R. F. Schell (1998)
Infect. Immun. 66, 1507-1512
 |  Abstract »  |  Full Text »  |  PDF »

A Surface-Exposed Region of a Novel Outer Membrane Protein (P66) of Borrelia spp. Is Variable in Size and Sequence.

J. Bunikis, C. J. Luke, E. Bunikiene, S. Bergström, and A. G. Barbour (1998)
J. Bacteriol. 180, 1618-1623
 |  Abstract »  |  Full Text »

Molecular Typing of Borrelia burgdorferi Sensu Lato by Randomly Amplified Polymorphic DNA Fingerprinting Analysis.

G. Wang, A. P. van Dam, L. Spanjaard, and J. Dankert (1998)
J. Clin. Microbiol. 36, 768-776
 |  Abstract »  |  Full Text »

Therapeutic passive vaccination against chronic Lyme disease in mice.

W. Zhong, T. Stehle, C. Museteanu, A. Siebers, L. Gern, M. Kramer, R. Wallich, and M. M. Simon (1997)
PNAS 94, 12533-12538
 |  Abstract »  |  Full Text »  |  PDF »

Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab.

H. Li, J. J. Dunn, B. J. Luft, and C. L. Lawson (1997)
PNAS 94, 3584-3589
 |  Abstract »  |  Full Text »  |  PDF »

The biological and social phenomenon of Lyme disease.

A. Barbour and D Fish (1993)
Science 260, 1610-1616
 |  Abstract »  |  PDF »

The Origin of Plagues: Old and New.

R. M. Krause (1992)
Science 257, 1073-1078
 |  Abstract »  |  PDF »

Biting back at Lyme disease..

J. Travis (1992)
Science 256, 1623
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PROGRESS TOWARD A LYME DISEASE VACCINE.

(1990)
Journal Watch (General) 1990, 10
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