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Science 26 October 1990:
Vol. 250. no. 4980, pp. 533 - 538
DOI: 10.1126/science.2122519
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Articles

Science, Vol 250, Issue 4980, 533-538
Copyright © 1990 by American Association for the Advancement of Science

articles

Biophysical and molecular mechanisms of Shaker potassium channel inactivation

T Hoshi, WN Zagotta, and RW Aldrich

Department of Molecular and Cellular Physiology, Stanford University, School of Medicine, CA 94305.

The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.


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Mutational Analysis of the {alpha}-1 Repeat of the Cardiac Na+-Ca2+ Exchanger.
M. Ottolia, D. A. Nicoll, and K. D. Philipson (2005)
J. Biol. Chem. 280, 1061-1069
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Molecular Diversity and Regulation of Renal Potassium Channels.
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Physiol Rev 85, 319-371
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Conformational Changes in the Phosphorylated C-terminal Domain of Rhodopsin during Rhodopsin Arrestin Interactions.
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Y3+ Block Demonstrates an Intracellular Activation Gate for the {alpha}1G T-type Ca2+ Channel.
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T. Shevchenko, R. Teruyama, and W. E. Armstrong (2004)
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T. Kitaguchi, M. Sukhareva, and K. J. Swartz (2004)
J. Gen. Physiol. 124, 319-332
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Regulation of K+ Flow by a Ring of Negative Charges in the Outer Pore of BKCa Channels. Part II: Neutralization of Aspartate 292 Reduces Long Channel Openings and Gating Current Slow Component.
T. Haug, R. Olcese, L. Toro, and E. Stefani (2004)
J. Gen. Physiol. 124, 185-197
   Abstract »    Full Text »    PDF »
"Disinactivation" of N-type Inactivation of Voltage-gated K Channels by an Erbstatin Analogue.
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J. Biol. Chem. 279, 29226-29230
   Abstract »    Full Text »    PDF »
Structure and Function of Kv4-Family Transient Potassium Channels.
S. G. Birnbaum, A. W. Varga, L.-L. Yuan, A. E. Anderson, J. D. Sweatt, and L. A. Schrader (2004)
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Intracellular Domains of a Rat Brain GABA Transporter That Govern Transport.
N. Hansra, S. Arya, and M. W. Quick (2004)
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Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore.
G. C. L. Bett and R. L. Rasmusson (2004)
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Membrane Tension Accelerates Rate-limiting Voltage-dependent Activation and Slow Inactivation Steps in a Shaker Channel.
U. Laitko and C. E. Morris (2004)
J. Gen. Physiol. 123, 135-154
   Abstract »    Full Text »    PDF »
Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels.
S. C. Stotz, S. E. Jarvis, and G. W. Zamponi (2004)
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The Binding of {kappa}-Conotoxin PVIIA and Fast C-Type Inactivation of Shaker K+ Channels are Mutually Exclusive.
E. D. Koch, B. M. Olivera, H. Terlau, and F. Conti (2004)
Biophys. J. 86, 191-209
   Abstract »    Full Text »    PDF »
N-type Inactivation Features of Kv4.2 Channel Gating.
M. Gebauer, D. Isbrandt, K. Sauter, B. Callsen, A. Nolting, O. Pongs, and R. Bahring (2004)
Biophys. J. 86, 210-223
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Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kv{beta}2-subunit.
O. Sokolova, A. Accardi, D. Gutierrez, A. Lau, M. Rigney, and N. Grigorieff (2003)
PNAS 100, 12607-12612
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Constitutive Activation of the Shaker Kv Channel.
M. Sukhareva, D. H. Hackos, and K. J. Swartz (2003)
J. Gen. Physiol. 122, 541-556
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Inactivation of Kv3.3 Potassium Channels in Heterologous Expression Systems.
F. R. Fernandez, E. Morales, A. J. Rashid, R. J. Dunn, and R. W. Turner (2003)
J. Biol. Chem. 278, 40890-40898
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Positive selection on protein-length in the evolution of a primate sperm ion channel.
O. Podlaha and J. Zhang (2003)
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Molecular Motions of the Outer Ring of Charge of the Sodium Channel: Do They Couple to Slow Inactivation?.
W. Xiong, R. A. Li, Y. Tian, and G. F. Tomaselli (2003)
J. Gen. Physiol. 122, 323-332
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Evidence for Intersubunit Interactions between S4 and S5 Transmembrane Segments of the Shaker Potassium Channel.
E. J. Neale, D. J. S. Elliott, M. Hunter, and A. Sivaprasadarao (2003)
J. Biol. Chem. 278, 29079-29085
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External TEA Block of Shaker K+ Channels Is Coupled to the Movement of K+ Ions within the Selectivity Filter.
J. Thompson and T. Begenisich (2003)
J. Gen. Physiol. 122, 239-246
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Differential Modulation of Cardiac Ca2+ Channel Gating by {beta}-Subunits.
I. Dzhura and A. Neely (2003)
Biophys. J. 85, 274-289
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Voltage-Gated K Channels.
C. M. Armstrong (2003)
Sci. STKE 2003, re10
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