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Science 19 October 1990:
Vol. 250. no. 4979, pp. 399 - 404
DOI: 10.1126/science.2218545
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Articles

Science, Vol 250, Issue 4979, 399-404
Copyright © 1990 by American Association for the Advancement of Science

articles

Transport and storage of vitamin A

R Blomhoff, MH Green, T Berg, and KR Norum

Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.

The requirement of vitamin A (retinoids) for vision has been recognized for decades. In addition, vitamin A is involved in fetal development and in the regulation of proliferation and differentiation of cells throughout life. This fat-soluble organic compound cannot be synthesized endogenously by humans and thus is an essential nutrient; a well-regulated transport and storage system provides tissues with the correct amounts of retinoids in spite of normal fluctuations in daily vitamin A intake. An overview is presented here of current knowledge and hypotheses about the absorption, transport, storage, and metabolism of vitamin A. Some information is also presented about a group of ligand-dependent transcription factors, the retinoic acid receptors, that apparently mediate many of the extravisual effects of retinoids.


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