Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 October 1990:
Vol. 250. no. 4979, pp. 399 - 404
DOI: 10.1126/science.2218545
Prev | Table of Contents | Next

Articles

Science, Vol 250, Issue 4979, 399-404
Copyright © 1990 by American Association for the Advancement of Science

articles

Transport and storage of vitamin A

R Blomhoff, MH Green, T Berg, and KR Norum

Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.

The requirement of vitamin A (retinoids) for vision has been recognized for decades. In addition, vitamin A is involved in fetal development and in the regulation of proliferation and differentiation of cells throughout life. This fat-soluble organic compound cannot be synthesized endogenously by humans and thus is an essential nutrient; a well-regulated transport and storage system provides tissues with the correct amounts of retinoids in spite of normal fluctuations in daily vitamin A intake. An overview is presented here of current knowledge and hypotheses about the absorption, transport, storage, and metabolism of vitamin A. Some information is also presented about a group of ligand-dependent transcription factors, the retinoic acid receptors, that apparently mediate many of the extravisual effects of retinoids.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of transcriptional regulatory cascades in retinoic acid-induced growth arrest of HepG2 cells.
M. Nakanishi, Y. Tomaru, H. Miura, Y. Hayashizaki, and M. Suzuki (2008)
Nucleic Acids Res. 36, 3443-3454
   Abstract »    Full Text »    PDF »
Vitamin A Concentrations in Piglet Extrahepatic Tissues Respond Differently Ten Days after Vitamin A Treatment.
T. Sun, R. L. Surles, and S. A. Tanumihardjo (2008)
J. Nutr. 138, 1101-1106
   Abstract »    Full Text »    PDF »
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver.
S. L. Friedman (2008)
Physiol Rev 88, 125-172
   Abstract »    Full Text »    PDF »
Identification and Characterization of Vitamin A-Storing Cells in Fetal Liver: Implications for Functional Importance of Hepatic Stellate Cells in Liver Development and Hematopoiesis.
H. Kubota, H.-l. Yao, and L. M. Reid (2007)
Stem Cells 25, 2339-2349
   Abstract »    Full Text »    PDF »
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A.
R. Kawaguchi, J. Yu, J. Honda, J. Hu, J. Whitelegge, P. Ping, P. Wiita, D. Bok, and H. Sun (2007)
Science 315, 820-825
   Abstract »    Full Text »    PDF »
The acute and chronic toxic effects of vitamin A.
K. L Penniston and S. A Tanumihardjo (2006)
Am. J. Clinical Nutrition 83, 191-201
   Abstract »    Full Text »    PDF »
Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats.
N. D. Oakes, P. Thalen, T. Hultstrand, S. Jacinto, G. Camejo, B. Wallin, and B. Ljung (2005)
Am J Physiol Regulatory Integrative Comp Physiol 289, R938-R946
   Abstract »    Full Text »    PDF »
The Drosophila ninaG Oxidoreductase Acts in Visual Pigment Chromophore Production.
S. Sarfare, S. T. Ahmad, M. V. Joyce, B. Boggess, and J. E. O'Tousa (2005)
J. Biol. Chem. 280, 11895-11901
   Abstract »    Full Text »    PDF »
The role of extrahepatic retinol binding protein in the mobilization of retinoid stores.
L. Quadro, W. S. Blaner, L. Hamberger, P. M. Novikoff, S. Vogel, R. Piantedosi, M. E. Gottesman, and V. Colantuoni (2004)
J. Lipid Res. 45, 1975-1982
   Abstract »    Full Text »    PDF »
Retinoic acid reverses the airway hyperresponsiveness but not the parenchymal defect that is associated with vitamin A deficiency.
S. E. McGowan, A. J. Holmes, and J. Smith (2004)
Am J Physiol Lung Cell Mol Physiol 286, L437-L444
   Abstract »    Full Text »    PDF »
Adolescent Diet and Incidence of Proliferative Benign Breast Disease.
H. J. Baer, S. J. Schnitt, J. L. Connolly, C. Byrne, E. Cho, W. C. Willett, and G. A. Colditz (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 1159-1167
   Abstract »    Full Text »
A Theoretical Increase in Infants' Hepatic Vitamin A Is Realized Using a Supplemented Lactating Sow Model.
K. L. Penniston, A. R. Valentine, and S. A. Tanumihardjo (2003)
J. Nutr. 133, 1139-1142
   Abstract »    Full Text »    PDF »
Activating Transcription Factor-2 Mediates Transcriptional Regulation of Gluconeogenic Gene PEPCK by Retinoic Acid.
M. Young Lee, C.-H. Jung, K. Lee, Y. Hyun Choi, S. Hong, and J. Cheong (2002)
Diabetes 51, 3400-3407
   Abstract »    Full Text »    PDF »
Retinoic Acid Stimulates the Cell Cycle Machinery in Normal T Cells: Involvement of Retinoic Acid Receptor-Mediated IL-2 Secretion.
A. Ertesvag, N. Engedal, S. Naderi, and H. K. Blomhoff (2002)
J. Immunol. 169, 5555-5563
   Abstract »    Full Text »    PDF »
Retinoic Acid-induced Growth Arrest and Differentiation: Retinoic Acid Up-Regulates CD32 (Fc{gamma}RII) Expression, the Ectopic Expression of Which Retards the Cell Cycle.
J. Wightman, M. S. Roberson, T. J. Lamkin, S. Varvayanis, and A. Yen (2002)
Mol. Cancer Ther. 1, 493-506
   Abstract »    Full Text »    PDF »
Possible Role of Retinoids in Hepatitis B Virus-Associated Liver Damage.
A. R. Mawson and T. A. Steele (2001)
Experimental Biology and Medicine 226, 734-739
   Abstract »    Full Text »    PDF »
Mechanisms Involved in the Intestinal Digestion and Absorption of Dietary Vitamin A.
E. H. Harrison and M. M. Hussain (2001)
J. Nutr. 131, 1405-1408
   Abstract »    Full Text »
Retinyl ester secretion by intestinal cells: a specific and regulated process dependent on assembly and secretion of chylomicrons.
N. Nayak, E. H. Harrison, and M. M. Hussain (2001)
J. Lipid Res. 42, 272-280
   Abstract »    Full Text »
Metabolism of Vitamin A and Its Active Metabolite All-trans-retinoic Acid in Small Intestinal Enterocytes.
A. Lampen, S. Meyer, T. Arnhold, and H. Nau (2000)
J. Pharmacol. Exp. Ther. 295, 979-985
   Abstract »    Full Text »
Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines.
X. Guo, A. Ruiz, R. R. Rando, D. Bok, and L. J. Gudas (2000)
Carcinogenesis 21, 1925-1933
   Abstract »    Full Text »    PDF »
Retinoids in chemoprevention and differentiation therapy.
L. A. Hansen, C. C. Sigman, F. Andreola, S. A. Ross, G. J. Kelloff, and L. M. De Luca (2000)
Carcinogenesis 21, 1271-1279
   Abstract »    Full Text »    PDF »
Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells.
M. A. Lane, A. C. Chen, S. D. Roman, F. Derguini, and L. J. Gudas (1999)
PNAS 96, 13524-13529
   Abstract »    Full Text »    PDF »
Serum vitamin A concentration is elevated in idiopathic intracranial hypertension.
D. M. Jacobson, R. Berg, M. Wall, K. B. Digre, J. J. Corbett, and R. D. Ellefson (1999)
Neurology 53, 1114
   Abstract »    Full Text »
Retinyl esters are hydrolyzed in early endosomes of J774 macrophages.
E. Hagen, A. M. Myhre, T. E. Tjelle, T. Berg, and K. R. Norum (1999)
J. Lipid Res. 40, 309-317
   Abstract »    Full Text »
Mobilization of Antioxidant Vitamin Pools and Hemodynamic Function After Myocardial Infarction.
V. P. Palace, M. F. Hill, F. Farahmand, and P. K. Singal (1999)
Circulation 99, 121-126
   Abstract »    Full Text »    PDF »
Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-21.
R. Homan and K. L. Hamelehle (1998)
J. Lipid Res. 39, 1197-1209
   Abstract »    Full Text »
Retinoid Metabolism in the Skin.
T. C. Roos, F. K. Jugert, H. F. Merk, and D. R. Bickers (1998)
Pharmacol. Rev. 50, 315-333
   Abstract »    Full Text »    PDF »
Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators.
M. Ashok, C. Turner, and T. G. Wilson (1998)
PNAS 95, 2761-2766
   Abstract »    Full Text »    PDF »
The Transfer of Retinol from Serum Retinol-binding Protein to Cellular Retinol-binding Protein Is Mediated by a Membrane Receptor.
M. Sundaram, A. Sivaprasadarao, M. M. DeSousa, and J. B. C. Findlay (1998)
J. Biol. Chem. 273, 3336-3342
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Second Retinoic Acid Response Element in the Phosphoenolpyruvate Carboxykinase Gene Promoter.
D. K. Scott, J. A. Mitchell, and D. K. Granner (1996)
J. Biol. Chem. 271, 6260-6264
   Abstract »    Full Text »    PDF »
In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer.
A Morrison, M. Moroni, L Ariza-McNaughton, R Krumlauf, and F Mavilio (1996)
Development 122, 1895-1907
   Abstract »    PDF »
Plasma Delivery of Retinoic Acid to Tissues in the Rat.
S. B. Kurlandsky, M. V. Gamble, R. Ramakrishnan, and W. S. Blaner (1995)
J. Biol. Chem. 270, 17850-17857
   Full Text »    PDF »
Retinol-binding Protein and Asialo-orosomucoid Are Taken Up by Different Pathways in Liver Cells.
L. Malaba, S. Smeland, H. Senoo, K. R. Norum, T. Berg, R. Blomhoff, and G. M. Kindberg (1995)
J. Biol. Chem. 270, 15686-15692
   Abstract »    Full Text »    PDF »
Studies on the Metabolism of Retinol and Retinol-binding Protein in Transthyretin-deficient Mice Produced by Homologous Recombination.
S. Wei, V. Episkopou, R. Piantedosi, S. Maeda, K. Shimada, M. E. Gottesman, and W. S. Blaner (1995)
J. Biol. Chem. 270, 866-870
   Abstract »    Full Text »    PDF »
Lazarillo, a new GPI-linked surface lipocalin, is restricted to a subset of neurons in the grasshopper embryo.
M. Ganfornina, D Sanchez, and M. Bastiani (1995)
Development 121, 123-134
   Abstract »    PDF »
Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer..
R Valcarcel, H Holz, C G Jimenez, D Barettino, and H G Stunnenberg (1994)
Genes & Dev. 8, 3068-3079
   Abstract »    PDF »
The Emerging Role of Vitamins as Antioxidants.
L. E. Johnson (1994)
Arch Fam Med 3, 809-818
   Abstract »    PDF »
A Prospective Study of the Intake of Vitamins C, E, and A and the Risk of Breast Cancer.
D. J. Hunter, J. E. Manson, G. A. Colditz, M. J. Stampfer, B. Rosner, C. H. Hennekens, F. E. Speizer, and W. C. Willett (1993)
N. Engl. J. Med. 329, 234-240
   Abstract »    Full Text »
A Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa.
E. L. Berson, B. Rosner, M. A. Sandberg, K. C. Hayes, B. W. Nicholson, C. Weigel-DiFranco, and W. Willett (1993)
Arch Ophthalmol 111, 761-772
   Abstract »    PDF »
An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development..
M Tini, G Otulakowski, M L Breitman, L C Tsui, and V Giguere (1993)
Genes & Dev. 7, 295-307
   Abstract »    PDF »
Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay.
M Wagner, B Han, and T. Jessell (1992)
Development 116, 55-66
   Abstract »    PDF »
The embryo takes its vitamins.
M Hoffman (1990)
Science 250, 372-373
   PDF »
Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity.
D. L. Misner, S. Jacobs, Y. Shimizu, A. M. de Urquiza, L. Solomin, T. Perlmann, L. M. De Luca, C. F. Stevens, and R. M. Evans (2001)
PNAS 98, 11714-11719
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)