Science 12 October 1990: Vol. 250. no. 4978, pp. 279 - 282 DOI: 10.1126/science.2218531

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Articles

G Protein-Coupled Receptors, Cholinergic Dysfunction, and A{beta} Toxicity in Alzheimer's Disease.

A. Thathiah and B. De Strooper (2009)
Science Signaling 2, re8
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Protective Effects of Rosa damascena and its Active Constituent on A{beta}(25-35)-induced Neuritic Atrophy.

S. Awale, C. Tohda, Y. Tezuka, M. Miyazaki, and S. Kadota (2009)
Evid. Based Complement. Altern. Med.
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Differential Processing of Amyloid-{beta} Precursor Protein Directs Human Embryonic Stem Cell Proliferation and Differentiation into Neuronal Precursor Cells.

P. Porayette, M. J. Gallego, M. M. Kaltcheva, R. L. Bowen, S. Vadakkadath Meethal, and C. S. Atwood (2009)
J. Biol. Chem. 284, 23806-23817
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Hyperhomocysteinemia Increases {beta}-Amyloid by Enhancing Expression of {gamma}-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain.

C.-E Zhang, W. Wei, Y.-H. Liu, J.-H. Peng, Q. Tian, G.-P. Liu, Y. Zhang, and J.-Z. Wang (2009)
Am. J. Pathol. 174, 1481-1491
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Amyloid {beta}-Protein Toxicity and the Pathogenesis of Alzheimer Disease.

B. A. Yankner and T. Lu (2009)
J. Biol. Chem. 284, 4755-4759
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Picomolar Amyloid-{beta} Positively Modulates Synaptic Plasticity and Memory in Hippocampus.

D. Puzzo, L. Privitera, E. Leznik, M. Fa, A. Staniszewski, A. Palmeri, and O. Arancio (2008)
J. Neurosci. 28, 14537-14545
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Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease.

K.-H. Sun, Y. de Pablo, F. Vincent, E. O. Johnson, A. K. Chavers, and K. Shah (2008)
Mol. Biol. Cell 19, 3052-3069
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Autoantibody-catalyzed Hydrolysis of Amyloid {beta} Peptide.

H. Taguchi, S. Planque, Y. Nishiyama, J. Symersky, S. Boivin, P. Szabo, R. P. Friedland, P. A. Ramsland, A. B. Edmundson, M. E. Weksler, et al. (2008)
J. Biol. Chem. 283, 4714-4722
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Stepwise dynamics of epitaxially growing single amyloid fibrils.

M. S. Z. Kellermayer, A. Karsai, M. Benke, K. Soos, and B. Penke (2008)
PNAS 105, 141-144
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The -amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism.

S. Petratos, Q.-X. Li, A. J. George, X. Hou, M. L. Kerr, S. E. Unabia, I. Hatzinisiriou, D. Maksel, M.-I. Aguilar, and D. H. Small (2008)
Brain 131, 90-108
 |  Abstract »  |  Full Text »  |  PDF »

Increase in Expression Levels and Resistance to Sulfhydryl Oxidation of Peroxiredoxin Isoforms in Amyloid beta-Resistant Nerve Cells.

R. C. Cumming, R. Dargusch, W. H. Fischer, and D. Schubert (2007)
J. Biol. Chem. 282, 30523-30534
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Targeting amyloid-beta in glaucoma treatment.

L. Guo, T. E. Salt, V. Luong, N. Wood, W. Cheung, A. Maass, G. Ferrari, F. Russo-Marie, A. M. Sillito, M. E. Cheetham, et al. (2007)
PNAS 104, 13444-13449
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses.

H.-g. Lee, X. Zhu, R. J. Castellani, A. Nunomura, G. Perry, and M. A. Smith (2007)
J. Pharmacol. Exp. Ther. 321, 823-829
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Pentraxin 1 Contributes to the Neuronal Damage Evoked by Amyloid-{beta} and Is Overexpressed in Dystrophic Neurites in Alzheimer's Brain.

M. A. Abad, M. Enguita, N. DeGregorio-Rocasolano, I. Ferrer, and R. Trullas (2006)
J. Neurosci. 26, 12735-12747
 |  Abstract »  |  Full Text »  |  PDF »

Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.

F. Medja, V. Lelievre, R. H. Fontaine, F. Lebas, P. Leroux, T. Ouimet, A. Saria, C. Rougeot, P. Dournaud, and P. Gressens (2006)
Brain 129, 3209-3223
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease..

L. Heredia, P. Helguera, S. de Olmos, G. Kedikian, F. Sola Vigo, F. LaFerla, M. Staufenbiel, J. de Olmos, J. Busciglio, A. Caceres, et al. (2006)
J. Neurosci. 26, 6533-6542
 |  Abstract »  |  Full Text »  |  PDF »

Lymphocyte toxicity of prion fragments..

J. Murali and R. Jayakumar (2006)
J. Biochem. 139, 329-338
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Intraneuronal {beta}-Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response.

J. Magrane, K. M. Rosen, R. C. Smith, K. Walsh, G. K. Gouras, and H. W. Querfurth (2005)
J. Neurosci. 25, 10960-10969
 |  Abstract »  |  Full Text »  |  PDF »

Dense-Core Plaques in Tg2576 and PSAPP Mouse Models of Alzheimer's Disease Are Centered on Vessel Walls.

S. Kumar-Singh, D. Pirici, E. McGowan, S. Serneels, C. Ceuterick, J. Hardy, K. Duff, D. Dickson, and C. Van Broeckhoven (2005)
Am. J. Pathol. 167, 527-543
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Akt-dependent Expression of NAIP-1 Protects Neurons against Amyloid-{beta} Toxicity.

S. Lesne, C. Gabriel, D. A. Nelson, E. White, E. T. MacKenzie, D. Vivien, and A. Buisson (2005)
J. Biol. Chem. 280, 24941-24947
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Sex, Hormones, and Alzheimer's Disease.

L. W. Baum (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 736-743
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{beta}-Amyloid Peptides Impair PKC-Dependent Functions of Metabotropic Glutamate Receptors in Prefrontal Cortical Neurons.

J. P. Tyszkiewicz and Z. Yan (2005)
J Neurophysiol 93, 3102-3111
 |  Abstract »  |  Full Text »  |  PDF »

Does Donepezil Treatment Slow the Progression of Hippocampal Atrophy in Patients With Alzheimer's Disease?.

M. Hashimoto, H. Kazui, K. Matsumoto, Y. Nakano, M. Yasuda, and E. Mori (2005)
Am J Psychiatry 162, 676-682
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{beta}-Amyloid-Induced Neurodegeneration and Protection by Structurally Diverse Microtubule-Stabilizing Agents.

M. L. Michaelis, S. Ansar, Y. Chen, E. R. Reiff, K. I. Seyb, R. H. Himes, K. L. Audus, and G. I. Georg (2005)
J. Pharmacol. Exp. Ther. 312, 659-668
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Staying Connected: Synapses in Alzheimer Disease.

H.-g. Lee, P. I. Moreira, X. Zhu, M. A. Smith, and G. Perry (2004)
Am. J. Pathol. 165, 1461-1464
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Enhanced Toxicity and Cellular Binding of a Modified Amyloid {beta} Peptide with a Methionine to Valine Substitution.

G. D. Ciccotosto, D. Tew, C. C. Curtain, D. Smith, D. Carrington, C. L. Masters, A. I. Bush, R. A. Cherny, R. Cappai, and K. J. Barnham (2004)
J. Biol. Chem. 279, 42528-42534
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Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule.

B. J. Blanchard, A. Chen, L. M. Rozeboom, K. A. Stafford, P. Weigele, and V. M. Ingram (2004)
PNAS 101, 14326-14332
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Islet Amyloid: A Critical Entity in the Pathogenesis of Type 2 Diabetes.

R. L. Hull, G. T. Westermark, P. Westermark, and S. E. Kahn (2004)
J. Clin. Endocrinol. Metab. 89, 3629-3643
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Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated {beta}-Amyloid-Induced Neurotoxicity.

G. Novarino, C. Fabrizi, R. Tonini, M. A. Denti, F. Malchiodi-Albedi, G. M. Lauro, B. Sacchetti, S. Paradisi, A. Ferroni, P. M. Curmi, et al. (2004)
J. Neurosci. 24, 5322-5330
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Identification of Cathepsin B as a Mediator of Neuronal Death Induced by A{beta}-activated Microglial Cells Using a Functional Genomics Approach.

L. Gan, S. Ye, A. Chu, K. Anton, S. Yi, V. A. Vincent, D. von Schack, D. Chin, J. Murray, S. Lohr, et al. (2004)
J. Biol. Chem. 279, 5565-5572
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Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/Threonine Protein Kinase in {beta}-Amyloid Peptide Neurotoxicity.

K.-C. Suen, M.-S. Yu, K.-F. So, R. C.-C. Chang, and J. Hugon (2003)
J. Biol. Chem. 278, 49819-49827
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Neurotoxic, Redox-competent Alzheimer's {beta}-Amyloid Is Released from Lipid Membrane by Methionine Oxidation.

K. J. Barnham, G. D. Ciccotosto, A. K. Tickler, F. E. Ali, D. G. Smith, N. A. Williamson, Y.-H. Lam, D. Carrington, D. Tew, G. Kocak, et al. (2003)
J. Biol. Chem. 278, 42959-42965
 |  Abstract »  |  Full Text »  |  PDF »

Glutamate and Amyloid {beta}-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms.

H. Hiruma, T. Katakura, S. Takahashi, T. Ichikawa, and T. Kawakami (2003)
J. Neurosci. 23, 8967-8977
 |  Abstract »  |  Full Text »  |  PDF »

Cu2+-induced modification of the kinetics of A{beta}(1-42) channels.

R. Bahadi, P. V. Farrelly, B. L. Kenna, C. C. Curtain, C. L. Masters, R. Cappai, K. J. Barnham, and J. I. Kourie (2003)
Am J Physiol Cell Physiol 285, C873-C880
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A{beta}1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.

E. Masliah, M. Alford, A. Adame, E. Rockenstein, D. Galasko, D. Salmon, L. A. Hansen, and L. J. Thal (2003)
Neurology 61, 206-211
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Impaired Modulation of GABAergic Transmission by Muscarinic Receptors in a Mouse Transgenic Model of Alzheimer's Disease.

P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan (2003)
J. Biol. Chem. 278, 26888-26896
 |  Abstract »  |  Full Text »  |  PDF »

Nicotine Enhances the Depressive Actions of A{beta}1-40 on Long-Term Potentiation in the Rat Hippocampal CA1 Region In Vivo.

D. B. Freir and C. E. Herron (2003)
J Neurophysiol 89, 2917-2922
 |  Abstract »  |  Full Text »  |  PDF »

A{beta}25-35-Induced Depression of Long-Term Potentiation in Area CA1 In Vivo and In Vitro Is Attenuated by Verapamil.

D. B. Freir, D. A. Costello, and C. E. Herron (2003)
J Neurophysiol 89, 3061-3069
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Muscarinic Receptors Inhibits beta -Amyloid Peptide-induced Signaling in Cortical Slices.

Z. Gu, P. Zhong, and Z. Yan (2003)
J. Biol. Chem. 278, 17546-17556
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Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid beta -Induced Neuronal Dystrophy.

E. A. Grace and J. Busciglio (2003)
J. Neurosci. 23, 493-502
 |  Abstract »  |  Full Text »  |  PDF »

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.

B. Urbanc, L. Cruz, R. Le, J. Sanders, K. H. Ashe, K. Duff, H. E. Stanley, M. C. Irizarry, and B. T. Hyman (2002)
PNAS 99, 13990-13995
 |  Abstract »  |  Full Text »  |  PDF »

Metalloenzyme-like Activity of Alzheimer's Disease beta -Amyloid. Cu-DEPENDENT CATALYTIC CONVERSION OF DOPAMINE, CHOLESTEROL, AND BIOLOGICAL REDUCING AGENTS TO NEUROTOXIC H2O2.

C. Opazo, X. Huang, R. A. Cherny, R. D. Moir, A. E. Roher, A. R. White, R. Cappai, C. L. Masters, R. E. Tanzi, N. C. Inestrosa, et al. (2002)
J. Biol. Chem. 277, 40302-40308
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Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease A{beta}P (1-40) and (1-42) peptides.

N. ARISPE and M. DOH (2002)
FASEB J 16, 1526-1536
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.

Y. Luo, J. V. Smith, V. Paramasivam, A. Burdick, K. J. Curry, J. P. Buford, I. Khan, W. J. Netzer, H. Xu, and P. Butko (2002)
PNAS 99, 12197-12202
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways.

T. D. Stein and J. A. Johnson (2002)
J. Neurosci. 22, 7380-7388
 |  Abstract »  |  Full Text »  |  PDF »

Oligomeric and Fibrillar Species of Amyloid-beta Peptides Differentially Affect Neuronal Viability.

K. N. Dahlgren, A. M. Manelli, W. B. Stine Jr., L. K. Baker, G. A. Krafft, and M. J. LaDu (2002)
J. Biol. Chem. 277, 32046-32053
 |  Abstract »  |  Full Text »  |  PDF »

beta -Amyloid Enhances Glial Glutamate Uptake Activity and Attenuates Synaptic Efficacy.

Y. Ikegaya, S. Matsuura, S. Ueno, A. Baba, M. K. Yamada, N. Nishiyama, and N. Matsuki (2002)
J. Biol. Chem. 277, 32180-32186
 |  Abstract »  |  Full Text »  |  PDF »

Probing solvent accessibility of amyloid fibrils by solution NMR spectroscopy.

J. H. Ippel, A. Olofsson, J. Schleucher, E. Lundgren, and S. S. Wijmenga (2002)
PNAS 99, 8648-8653
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Function of Monomeric Amyloid beta -Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage.

K. Zou, J.-S. Gong, K. Yanagisawa, and M. Michikawa (2002)
J. Neurosci. 22, 4833-4841
 |  Abstract »  |  Full Text »  |  PDF »

The Tachykinin Peptide Family.

C. Severini, G. Improta, G. Falconieri-Erspamer, S. Salvadori, and V. Erspamer (2002)
Pharmacol. Rev. 54, 285-322
 |  Abstract »  |  Full Text »  |  PDF »

Peroxynitrite Mediates Neurotoxicity of Amyloid beta -Peptide1-42- and Lipopolysaccharide-Activated Microglia.

Z. Xie, M. Wei, T. E. Morgan, P. Fabrizio, D. Han, C. E. Finch, and V. D. Longo (2002)
J. Neurosci. 22, 3484-3492
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal nicotinic acetylcholine receptors: involvement in Alzheimer's disease and schizophrenia..

D. S. Woodruff-Pak and T. J. Gould (2002)
Behav Cogn Neurosci Rev 1, 5-20
 |  Abstract »  |  PDF »

Contrasting, Species-Dependent Modulation of Copper-Mediated Neurotoxicity by the Alzheimer's Disease Amyloid Precursor Protein.

A. R. White, G. Multhaup, D. Galatis, W. J. McKinstry, M. W. Parker, R. Pipkorn, K. Beyreuther, C. L. Masters, and R. Cappai (2002)
J. Neurosci. 22, 365-376
 |  Abstract »  |  Full Text »  |  PDF »

Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults.

Y. Hashimoto, T. Niikura, Y. Ito, H. Sudo, M. Hata, E. Arakawa, Y. Abe, Y. Kita, and I. Nishimoto (2001)
J. Neurosci. 21, 9235-9245
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid {beta} protein forms ion channels: implications for Alzheimer's disease pathophysiology.

H. LIN, R. BHATIA, and R. LAL (2001)
FASEB J 15, 2433-2444
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand.

Y. Morishima, Y. Gotoh, J. Zieg, T. Barrett, H. Takano, R. Flavell, R. J. Davis, Y. Shirasaki, and M. E. Greenberg (2001)
J. Neurosci. 21, 7551-7560
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Aggregated {beta}-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits.

A. Stephan, S. Laroche, and S. Davis (2001)
J. Neurosci. 21, 5703-5714
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Human Macrophages by Amyloid-{{beta}} Is Attenuated by Astrocytes.

H. A. Smits, A. J. van Beelen, N. M. de Vos, A. Rijsmus, T. van der Bruggen, J. Verhoef, F. L. van Muiswinkel, and H. S. L. M. Nottet (2001)
J. Immunol. 166, 6869-6876
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Long-Term Potentiation by {beta}-Amyloid Peptides in the CA1 Region of the Rat Hippocampus In Vivo.

D. B. Freir, C. Holscher, and C. E. Herron (2001)
J Neurophysiol 85, 708-713
 |  Abstract »  |  Full Text »  |  PDF »

Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

H.-S. KIM, C. H. PARK, S. H. CHA, J.-H. LEE, S. LEE, Y. KIM, J.-C. RAH, S.-J. JEONG, and Y.-H. SUH (2000)
FASEB J 14, 1508-1517
 |  Abstract »  |  Full Text »

Fresh and globular amyloid {beta} protein (1-42) induces rapid cellular degeneration: evidence for A{beta}P channel-mediated cellular toxicity.

R. BHATIA, H. LIN, and R. LAL (2000)
FASEB J 14, 1233-1243
 |  Abstract »  |  Full Text »

Fresh and nonfibrillar amyloid {beta} protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: evidence for A{beta}P-channel-mediated cellular toxicity.

Y. J. ZHU, H. LIN, and R. LAL (2000)
FASEB J 14, 1244-1254
 |  Abstract »  |  Full Text »

Alzheimer's beta -Amyloid, Human Islet Amylin, and Prion Protein Fragment Evoke Intracellular Free Calcium Elevations by a Common Mechanism in a Hypothalamic GnRH Neuronal Cell Line.

M. Kawahara, Y. Kuroda, N. Arispe, and E. Rojas (2000)
J. Biol. Chem. 275, 14077-14083
 |  Abstract »  |  Full Text »  |  PDF »

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3.

A. Giovanni, E. Keramaris, E. J. Morris, S. T. Hou, M. O'Hare, N. Dyson, G. S. Robertson, R. S. Slack, and D. S. Park (2000)
J. Biol. Chem. 275, 11553-11560
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic processing and cell biological functions of the amyloid precursor protein.

B De Strooper and W Annaert (2000)
J. Cell Sci. 113, 1857-1870
 |  Abstract »  |  PDF »

The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures.

A. R. White, G. Multhaup, F. Maher, S. Bellingham, J. Camakaris, H. Zheng, A. I. Bush, K. Beyreuther, C. L. Masters, and R. Cappai (1999)
J. Neurosci. 19, 9170-9179
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta -Protein Fibrillogenesis. STRUCTURE AND BIOLOGICAL ACTIVITY OF PROTOFIBRILLAR INTERMEDIATES.

D. M. Walsh, D. M. Hartley, Y. Kusumoto, Y. Fezoui, M. M. Condron, A. Lomakin, G. B. Benedek, D. J. Selkoe, and D. B. Teplow (1999)
J. Biol. Chem. 274, 25945-25952
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein.

T. Uetsuki, K. Takemoto, I. Nishimura, M. Okamoto, M. Niinobe, T. Momoi, M. Miura, and K. Yoshikawa (1999)
J. Neurosci. 19, 6955-6964
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer's Disease.

A. LeBlanc, H. Liu, C. Goodyer, C. Bergeron, and J. Hammond (1999)
J. Biol. Chem. 274, 23426-23436
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of NF-kappa B potentiates amyloid beta -mediated neuronal apoptosis.

B. Kaltschmidt, M. Uherek, H. Wellmann, B. Volk, and C. Kaltschmidt (1999)
PNAS 96, 9409-9414
 |  Abstract »  |  Full Text »  |  PDF »

Receptor for Advanced Glycation End Products (RAGE)-mediated Neurite Outgrowth and Activation of NF-kappa B Require the Cytoplasmic Domain of the Receptor but Different Downstream Signaling Pathways.

H. J. Huttunen, C. Fages, and H. Rauvala (1999)
J. Biol. Chem. 274, 19919-19924
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death.

A. Giovanni, F. Wirtz-Brugger, E. Keramaris, R. Slack, and D. S. Park (1999)
J. Biol. Chem. 274, 19011-19016
 |  Abstract »  |  Full Text »  |  PDF »

beta -Amyloid Activates the Obardot 2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils. A POSSIBLE INFLAMMATORY MECHANISM OF NEURONAL DAMAGE IN ALZHEIMER'S DISEASE.

V. Della Bianca, S. Dusi, E. Bianchini, I. Dal Pra, and F. Rossi (1999)
J. Biol. Chem. 274, 15493-15499
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta  Peptides Do Not Form Peptide-derived Free Radicals Spontaneously, but Can Enhance Metal-catalyzed Oxidation of Hydroxylamines to Nitroxides.

S. I. Dikalov, M. P. Vitek, K. R. Maples, and R. P. Mason (1999)
J. Biol. Chem. 274, 9392-9399
 |  Abstract »  |  Full Text »  |  PDF »

A ßPP Peptide Carboxyl-Terminal to Aß Is Neurotoxic.

G. Marcon, G. Giaccone, B. Canciani, L. Cajola, G. Rossi, L. De Gioia, M. Salmona, O. Bugiani, and F. Tagliavini (1999)
Am. J. Pathol. 154, 1001-1007
 |  Abstract »  |  Full Text »  |  PDF »

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

A. Y. Hsia, E. Masliah, L. McConlogue, G.-Q. Yu, G. Tatsuno, K. Hu, D. Kholodenko, R. C. Malenka, R. A. Nicoll, and L. Mucke (1999)
PNAS 96, 3228-3233
 |  Abstract »  |  Full Text »  |  PDF »

CSF beta-amyloid, cognition, and APOE genotype in Alzheimer's disease.

S. C. Samuels, J. M. Silverman, D. B. Marin, E. R. Peskind, S. G. Younki, D. A. Greenberg, E. Schnur, J. Santoro, and K. L. Davis (1999)
Neurology 52, 547
 |  Abstract »  |  Full Text »  |  PDF »

The Neurobiology and Pharmacotherapy of Alzheimer's Disease.

O. Felician and T. A. Sandson (1999)
J Neuropsychiatry Clin Neurosci 11, 19-31
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Multiple Pathways of Apoptosis in PC12 Cells. CrmA INHIBITS APOPTOSIS INDUCED BY beta -AMYLOID.

K. J. Ivins, J. K. Ivins, J. P. Sharp, and C. W. Cotman (1999)
J. Biol. Chem. 274, 2107-2112
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Amyloid beta  peptide alters intracellular vesicle trafficking and cholesterol homeostasis.

Y. Liu, D. A. Peterson, and D. Schubert (1998)
PNAS 95, 13266-13271
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Amyloid beta -Peptide Possesses a Transforming Growth Factor-beta Activity.

S. S. Huang, F. W. Huang, J. Xu, S. Chen, C. Y. Hsu, and J. S. Huang (1998)
J. Biol. Chem. 273, 27640-27644
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Protease Inhibitor Coinfusion with Amyloid beta -Protein Results in Enhanced Deposition and Toxicity in Rat Brain.

S. A. Frautschy, D. L. Horn, J. J. Sigel, M. E. Harris-White, J. J. Mendoza, F. Yang, T. C. Saido, and G. M. Cole (1998)
J. Neurosci. 18, 8311-8321
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Survival of Cultured Neurons from Amyloid Precursor Protein Knock-Out Mice against Alzheimer's Amyloid-beta Toxicity and Oxidative Stress.

A. R. White, H. Zheng, D. Galatis, F. Maher, L. Hesse, G. Multhaup, K. Beyreuther, C. L. Masters, and R. Cappai (1998)
J. Neurosci. 18, 6207-6217
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Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons.

N. Y. Barnes, L. Li, K. Yoshikawa, L. M. Schwartz, R. W. Oppenheim, and C. E. Milligan (1998)
J. Neurosci. 18, 5869-5880
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beta -Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes.

D. R. McDonald, M. E. Bamberger, C. K. Combs, and G. E. Landreth (1998)
J. Neurosci. 18, 4451-4460
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Amyloid beta  Protein-(1-42) Forms Calcium-permeable, Zn2+-sensitive Channel.

S. K. Rhee, A. P. Quist, and R. Lal (1998)
J. Biol. Chem. 273, 13379-13382
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Diffusible, nonfibrillar ligands derived from Abeta 1-42 are potent central nervous system neurotoxins.

M. P. Lambert, A. K. Barlow, B. A. Chromy, C. Edwards, R. Freed, M. Liosatos, T. E. Morgan, I. Rozovsky, B. Trommer, K. L. Viola, et al. (1998)
PNAS 95, 6448-6453
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Alzheimer's-specific effects of soluble beta -amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.

A. Favit, M. Grimaldi, T. J. Nelson, and D. L. Alkon (1998)
PNAS 95, 5562-5567
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Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Abeta Production in Human Primary Neuron Cultures..

A. C. LeBlanc, M. Koutroumanis, and C. G. Goodyer (1998)
J. Neurosci. 18, 2907-2913
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Inhibition of Alzheimer beta -Fibrillogenesis by Melatonin.

M. Pappolla, P. Bozner, C. Soto, H. Shao, N. K. Robakis, M. Zagorski, B. Frangione, and J. Ghiso (1998)
J. Biol. Chem. 273, 7185-7188
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Fibrillar beta -Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo.

D. T. Weldon, S. D. Rogers, J. R. Ghilardi, M. P. Finke, J. P. Cleary, E. O'Hare, W. P. Esler, J. E. Maggio, and P. W. Mantyh (1998)
J. Neurosci. 18, 2161-2173
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Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease.

L. Gasparini, M. Racchi, G. Binetti, M. Trabucchi, S. B. Solerte, D. Alkon, R. Etcheberrigaray, G. Gibson, J. Blass, R. Paoletti, et al. (1998)
FASEB J 12, 17-34
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Isoform-Specific Effect of Apolipoprotein E on Cell Survival and beta -Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures.

J. Jordan, M. F. Galindo, R. J. Miller, C. A. Reardon, G. S. Getz, and M. J. LaDu (1998)
J. Neurosci. 18, 195-204
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The beta -Amyloid Precursor Protein of Alzheimer's Disease Enhances Neuron Viability and Modulates Neuronal Polarity.

R. G. Perez, H. Zheng, L. H. T. Van der Ploeg, and E. H. Koo (1997)
J. Neurosci. 17, 9407-9414
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Zinc-induced Alzheimer's Abeta 1-40 Aggregation Is Mediated by Conformational Factors.

X. Huang, C. S. Atwood, R. D. Moir, M. A. Hartshorn, J.-P. Vonsattel, R. E. Tanzi, and A. I. Bush (1997)
J. Biol. Chem. 272, 26464-26470
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Developmental Regulation of Presenilin-1 Processing in the Brain Suggests a Role in Neuronal Differentiation.

H. Hartmann, J. Busciglio, K.-H. Baumann, M. Staufenbiel, and B. A. Yankner (1997)
J. Biol. Chem. 272, 14505-14508
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Amyloid-beta peptide-Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease.

S. Du Yan, H. Zhu, J. Fu, S. F. Yan, A. Roher, W. W. Tourtellotte, T. Rajavashisth, X. Chen, G. C. Godman, D. Stern, et al. (1997)
PNAS 94, 5296-5301
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Controlling Amyloid beta -Peptide Fibril Formation with Protease-stable Ligands.

L. O. Tjernberg, C. Lilliehook, D. J. E. Callaway, J. Naslund, S. Hahne, J. Thyberg, L. Terenius, and C. Nordstedt (1997)
J. Biol. Chem. 272, 12601-12605
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Disaggregation of Alzheimer beta -amyloid by site-directed mAb.

B. Solomon, R. Koppel, D. Frankel, and E. Hanan-Aharon (1997)
PNAS 94, 4109-4112
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