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Science 12 October 1990: Vol. 250. no. 4978, pp. 276 - 279 DOI: 10.1126/science.2218530
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Articles
Science, Vol 250, Issue 4978, 276-279
Copyright © 1990 by American Association for the Advancement of Science
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels
R MacKinnon
and
G Yellen
Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA 02115.
Voltage-dependent ion channels are responsible for electrical signaling in neurons and other cells. The main classes of voltage-dependent channels (sodium-, calcium-, and potassium-selective channels) have closely related molecular structures. For one member of this superfamily, the transiently voltage-activated Shaker H4 potassium channel, specific amino acid residues have now been identified that affect channel blockade by the small ion tetraethylammonium, as well as the conduction of ions through the pore. Furthermore, variation at one of these amino acid positions among naturally occurring potassium channels may account for most of their differences in sensitivity to tetraethylammonium.
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- Flexibility of the Kir6.2 inward rectifier K+ channel pore.
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PNAS
98, 4227-4232
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- Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants.
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PNAS
99, 6428-6433
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