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Science 28 September 1990:
Vol. 249. no. 4976, pp. 1564 - 1566
DOI: 10.1126/science.2218498
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Articles

Science, Vol 249, Issue 4976, 1564-1566
Copyright © 1990 by American Association for the Advancement of Science

articles

Protection from chemotherapy-induced alopecia in a rat model

AM Hussein, JJ Jimenez, CA McCall, and AA Yunis

Department of Medicine, University of Miami School of Medicine, FL 33101.

Alopecia (hair loss) is among the most distressing side effects of cancer chemotherapy. Little progress has been made, however, in its prevention or treatment, partly because of the lack of suitable experimental model. In recent work on the treatment of myelogenous leukemia in the rat, the following observations were made: (i) treatment of 8-day-old rats with cytosine arabinoside consistently produced alopecia, and (ii) ImuVert, a biologic response modifier derived from the bacterium Serratia marcescens, uniformly produced complete protection against the alopecia. In subsequent experiments, both cyclophosphamide and doxorubicin also produced alopecia in this model, and the doxorubicin-induced alopecia was prevented by treatment with ImuVert. The potential relevance of these observations to chemotherapy-induced alopecia in the clinical setting should be examined.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dissecting the Impact of Chemotherapy on the Human Hair Follicle: A Pragmatic in Vitro Assay for Studying the Pathogenesis and Potential Management of Hair Follicle Dystrophy.
E. Bodo, D. J. Tobin, Y. Kamenisch, T. Biro, M. Berneburg, W. Funk, and R. Paus (2007)
Am. J. Pathol. 171, 1153-1167
   Abstract »    Full Text »    PDF »
Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia.
N. Sato, P. L. Leopold, and R. G. Crystal (2001)
J Natl Cancer Inst 93, 1858-1864
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)