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Science 21 September 1990:
Vol. 249. no. 4975, pp. 1438 - 1441
DOI: 10.1126/science.2402639
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Articles

Science, Vol 249, Issue 4975, 1438-1441
Copyright © 1990 by American Association for the Advancement of Science

articles

Xotch, the Xenopus homolog of Drosophila notch

C Coffman, W Harris, and C Kintner

Department of Biology, University of California, La Jolla 92093.

During the development of a vertebrate embryo, cell fate is determined by inductive signals passing between neighboring tissues. Such determinative interactions have been difficult to characterize fully without knowledge of the molecular mechanisms involved. Mutations of Drosophila and the nematode Caenorhabditis elegans have been isolated that define a family of related gene products involved in similar types of cellular inductions. One of these genes, the Notch gene from Drosophila, is involved with cell fate choices in the neurogenic region of the blastoderm, in the developing nervous system, and in the eye-antennal imaginal disc. Complementary DNA clones were isolated from Xenopus embryos with Notch DNA in order to investigate whether cell-cell interactions in vertebrate embryos also depend on Notch-like molecules. This approach identified a Xenopus molecule, Xotch, which is remarkably similar to Drosophila Notch in both structure and developmental expression.


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The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo.
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A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neuroectoderm.
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Regulative interactions in zebrafish neural crest.
D. Raible and J. Eisen (1996)
Development 122, 501-507
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The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling..
M Lecourtois and F Schweisguth (1995)
Genes & Dev. 9, 2598-2608
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The cDNA Sequence of Human Endothelial Cell Multimerin.
C. P. M. Hayward, J. A. Hassell, G. A. Denomme, R. A. Rachubinski, C. Brown, and J. G. Kelton (1995)
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Notch signaling.
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Mussel Adhesive Plaque Protein Gene Is a Novel Member of Epidermal Growth Factor-like Gene Family.
K. Inoue, Y. Takeuchi, D. Miki, and S. Odo (1995)
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Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.
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Notch1 is required for the coordinate segmentation of somites.
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Vertebrate embryonic induction: mesodermal and neural patterning.
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The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
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An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells.
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Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate..
D L Turner and H Weintraub (1994)
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Notch1 is essential for postimplantation development in mice..
P J Swiatek, C E Lindsell, F F del Amo, G Weinmaster, and T Gridley (1994)
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The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo.
B Jennings, A Preiss, C Delidakis, and S Bray (1994)
Development 120, 3537-3548
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Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
R. Diederich, K Matsuno, H Hing, and S Artavanis-Tsakonas (1994)
Development 120, 473-481
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Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch.
J. Aster, W. Pear, R. Hasserjian, H. Erba, F. Davi, B. Luo, M. Scott, D. Baltimore, and J. Sklar (1994)
Cold Spring Harb Symp Quant Biol 59, 125-136
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Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage.
H. Schnurch and W. Risau (1993)
Development 119, 957-968
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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei..
T Lieber, S Kidd, E Alcamo, V Corbin, and M W Young (1993)
Genes & Dev. 7, 1949-1965
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Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions.
P Heitzler and P Simpson (1993)
Development 117, 1113-1123
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Notch2: a second mammalian Notch gene.
G. Weinmaster, V. J. Roberts, and G. Lemke (1992)
Development 116, 931-941
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Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia.
M Mayford, A Barzilai, F Keller, S Schacher, and E. Kandel (1992)
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Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands..
C Jhappan, D Gallahan, C Stahle, E Chu, G H Smith, G Merlino, and R Callahan (1992)
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Characterization of a germ-line proliferation mutation in C. elegans.
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Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
F. Del Amo, D. Smith, P. Swiatek, M Gendron-Maguire, R. Greenspan, A. McMahon, and T Gridley (1992)
Development 115, 737-744
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Delta, Notch, and shaggy: Elements of a Lateral Signaling Pathway in Drosophila.
P. Simpson, M. Bourouis, P. Heitzler, L. Ruel, M. Haenlin, and P. Ramain (1992)
Cold Spring Harb Symp Quant Biol 57, 391-400
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Regulation of Induction by GLP1, a Localized Cell Surface Receptor in Caenorhabditis elegans.
J. Kimble, S. Crittenden, E. Lambie, V. Kodoyianni, S. Mango, and E. Troemel (1992)
Cold Spring Harb Symp Quant Biol 57, 401-407
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HRR25, a putative protein kinase from budding yeast: association with repair of damaged DNA.
M. Hoekstra, R. Liskay, A. Ou, A. DeMaggio, D. Burbee, and F Heffron (1991)
Science 253, 1031-1034
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Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous.
N. Baker, M Mlodzik, and G. Rubin (1990)
Science 250, 1370-1377
   Abstract »    PDF »


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