Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 21 September 1990:
Vol. 249. no. 4975, pp. 1436 - 1438
DOI: 10.1126/science.2402638

Articles

Science, Vol 249, Issue 4975, 1436-1438
Copyright © 1990 by American Association for the Advancement of Science


articles

Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

H Bergman, T Wichmann, and MR DeLong

Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21205.

Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in the substantia nigra, the resulting alterations in activity in the basal ganglia responsible for parkinsonian motor deficits are still poorly characterized. Recently, increased activity in the subthalamic nucleus has been implicated in the motor abnormalities. To test this hypothesis, the effects of lesions of the subthalamic nucleus were evaluated in monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The lesions reduced all of the major motor disturbances in the contralateral limbs, including akinesia, rigidity, and tremor. This result supports the postulated role of excessive activity in the subthalamic nucleus in Parkinson's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Does subthalamotomy have a place in the treatment of Parkinson's disease?.
D. Tarsy (2009)
J. Neurol. Neurosurg. Psychiatry 80, 939-940
   Full Text »    PDF »
Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months.
L Alvarez, R Macias, N Pavon, G Lopez, M C Rodriguez-Oroz, R Rodriguez, M Alvarez, I Pedroso, J Teijeiro, R Fernandez, et al. (2009)
J. Neurol. Neurosurg. Psychiatry 80, 979-985
   Abstract »    Full Text »    PDF »
The scientific and clinical basis for the treatment of Parkinson disease (2009).
C. W. Olanow, M. B. Stern, and K. Sethi (2009)
Neurology 72, S1-S136
   Abstract »    Full Text »    PDF »
Cortical Effects of Subthalamic Stimulation Correlate with Behavioral Recovery from Dopamine Antagonist Induced Akinesia.
C. Dejean, B. Hyland, and G. Arbuthnott (2009)
Cereb Cortex 19, 1055-1063
   Abstract »    Full Text »    PDF »
Treatments for Parkinson disease--past achievements and current clinical needs.
W. Poewe (2009)
Neurology 72, S65-S73
   Abstract »    Full Text »    PDF »
Neurostimulation for Parkinson Disease.
G. Deuschl (2009)
JAMA 301, 104-105
   Full Text »    PDF »
Balance of Increases and Decreases in Firing Rate of the Spontaneous Activity of Basal Ganglia High-Frequency Discharge Neurons.
S. Elias, Y. Ritov, and H. Bergman (2008)
J Neurophysiol 100, 3086-3104
   Abstract »    Full Text »    PDF »
Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.
J. F. Atherton, D. L. Wokosin, S. Ramanathan, and M. D. Bevan (2008)
J. Physiol. 586, 5679-5700
   Abstract »    Full Text »    PDF »
Subthalamic Nucleus Stimulation Modulates Thalamic Neuronal Activity.
W. Xu, G. S. Russo, T. Hashimoto, J. Zhang, and J. L. Vitek (2008)
J. Neurosci. 28, 11916-11924
   Abstract »    Full Text »    PDF »
Neuronal Activity of the Human Subthalamic Nucleus in the Parkinsonian and Nonparkinsonian State.
F. Steigerwald, M. Potter, J. Herzog, M. Pinsker, F. Kopper, H. Mehdorn, G. Deuschl, and J. Volkmann (2008)
J Neurophysiol 100, 2515-2524
   Abstract »    Full Text »    PDF »
High-Frequency Stimulation of the Anterior Subthalamic Nucleus Reduces Stereotyped Behaviors in Primates.
N. Baup, D. Grabli, C. Karachi, S. Mounayar, C. Francois, J. Yelnik, J. Feger, and L. Tremblay (2008)
J. Neurosci. 28, 8785-8788
   Abstract »    Full Text »    PDF »
A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats.
K. Mukhida, M. Hong, G.B. Miles, T. Phillips, B.A. Baghbaderani, M. McLeod, N. Kobayashi, A. Sen, L.A. Behie, R.M. Brownstone, et al. (2008)
Brain 131, 2106-2126
   Abstract »    Full Text »    PDF »
Role for Subthalamic Nucleus Neurons in Switching from Automatic to Controlled Eye Movement.
M. Isoda and O. Hikosaka (2008)
J. Neurosci. 28, 7209-7218
   Abstract »    Full Text »    PDF »
D2-like dopamine receptor-mediated modulation of activity-dependent plasticity at GABAergic synapses in the subthalamic nucleus.
J. Baufreton and M. D. Bevan (2008)
J. Physiol. 586, 2121-2142
   Abstract »    Full Text »    PDF »
D2-Like Dopamine Receptors Modulate SKCa Channel Function in Subthalamic Nucleus Neurons Through Inhibition of Cav2.2 Channels.
S. Ramanathan, T. Tkatch, J. F. Atherton, C. J. Wilson, and M. D. Bevan (2008)
J Neurophysiol 99, 442-459
   Abstract »    Full Text »    PDF »
Low-Pass Filter Properties of Basal Ganglia Cortical Muscle Loops in the Normal and MPTP Primate Model of Parkinsonism.
M. Rivlin-Etzion, O. Marmor, G. Saban, B. Rosin, S. N. Haber, E. Vaadia, Y. Prut, and H. Bergman (2008)
J. Neurosci. 28, 633-649
   Abstract »    Full Text »    PDF »
Nav1.6 Sodium Channels Are Critical to Pacemaking and Fast Spiking in Globus Pallidus Neurons.
J. N. Mercer, C. S. Chan, T. Tkatch, J. Held, and D. J. Surmeier (2007)
J. Neurosci. 27, 13552-13566
   Abstract »    Full Text »    PDF »
Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism.
M. J. Frank, J. Samanta, A. A. Moustafa, and S. J. Sherman (2007)
Science 318, 1309-1312
   Abstract »    Full Text »    PDF »
Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.
Y. Temel, L. J. Boothman, A. Blokland, P. J. Magill, H. W. M. Steinbusch, V. Visser-Vandewalle, and T. Sharp (2007)
PNAS 104, 17087-17092
   Abstract »    Full Text »    PDF »
Noradrenergic Modulation of Subthalamic Nucleus Activity: Behavioral and Electrophysiological Evidence in Intact and 6-Hydroxydopamine-Lesioned Rats.
P. Belujon, E. Bezard, A. Taupignon, B. Bioulac, and A. Benazzouz (2007)
J. Neurosci. 27, 9595-9606
   Abstract »    Full Text »    PDF »
A Calcium-Activated Nonselective Cation Conductance Underlies the Plateau Potential in Rat Substantia Nigra GABAergic Neurons.
C. R. Lee and J. M. Tepper (2007)
J. Neurosci. 27, 6531-6541
   Abstract »    Full Text »    PDF »
Subthalamic stimulation-induced forelimb dyskinesias are linked to an increase in glutamate levels in the substantia nigra pars reticulata..
S. Boulet, E. Lacombe, C. Carcenac, C. Feuerstein, V. Sgambato-Faure, A. Poupard, and M. Savasta (2006)
J. Neurosci. 26, 10768-10776
   Abstract »    Full Text »    PDF »
History of the corpus luysii: 1865-1995..
R. Hameleers, Y. Temel, and V. Visser-Vandewalle (2006)
Arch Neurol 63, 1340-1342
   Full Text »    PDF »
Dopamine Replacement Therapy Does Not Restore the Full Spectrum of Normal Pallidal Activity in the 1-Methyl-4-Phenyl-1,2,3,6-Tetra-Hydropyridine Primate Model of Parkinsonism.
G. Heimer, M. Rivlin-Etzion, I. Bar-Gad, J. A. Goldberg, S. N. Haber, and H. Bergman (2006)
J. Neurosci. 26, 8101-8114
   Abstract »    Full Text »    PDF »
Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro.
K.-Z. Shen and S. W. Johnson (2006)
J. Physiol. 573, 697-709
   Abstract »    Full Text »    PDF »
Surgical insights into Parkinson's disease..
E. A C Pereira and T. Z Aziz (2006)
J R Soc Med 99, 238-244
   Abstract »    Full Text »    PDF »
Parkinson's disease and primate research: past, present, and future..
E A C Pereira and T Z Aziz (2006)
Postgrad. Med. J. 82, 293-299
   Abstract »    Full Text »    PDF »
Membrane Channel Interactions Underlying Rat Subthalamic Projection Neuron Rhythmic and Bursting Activity.
A. Gillies and D. Willshaw (2006)
J Neurophysiol 95, 2352-2365
   Abstract »    Full Text »    PDF »
Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia..
A. Leblois, T. Boraud, W. Meissner, H. Bergman, and D. Hansel (2006)
J. Neurosci. 26, 3567-3583
   Abstract »    Full Text »    PDF »
Silent plateau potentials, rhythmic bursts, and pacemaker firing: Three patterns of activity that coexist in quadristable subthalamic neurons.
J. I. Kass and I. M. Mintz (2006)
PNAS 103, 183-188
   Abstract »    Full Text »    PDF »
Impact of High-Frequency Stimulation Parameters on the Pattern of Discharge of Subthalamic Neurons.
L. Garcia, G. D'Alessandro, P.-O. Fernagut, B. Bioulac, and C. Hammond (2005)
J Neurophysiol 94, 3662-3669
   Abstract »    Full Text »    PDF »
Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease.
M. Marti, F. Mela, M. Fantin, S. Zucchini, J. M. Brown, J. Witta, M. Di Benedetto, B. Buzas, R. K. Reinscheid, S. Salvadori, et al. (2005)
J. Neurosci. 25, 9591-9601
   Abstract »    Full Text »    PDF »
Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.
M. C. Rodriguez-Oroz, J. A. Obeso, A. E. Lang, J.-L. Houeto, P. Pollak, S. Rehncrona, J. Kulisevsky, A. Albanese, J. Volkmann, M. I. Hariz, et al. (2005)
Brain 128, 2240-2249
   Abstract »    Full Text »    PDF »
Balance of Monosynaptic Excitatory and Disynaptic Inhibitory Responses of the Globus Pallidus Induced after Stimulation of the Subthalamic Nucleus in the Monkey.
H. Kita, Y. Tachibana, A. Nambu, and S. Chiken (2005)
J. Neurosci. 25, 8611-8619
   Abstract »    Full Text »    PDF »
Subthalamic Neurons Coordinate Basal Ganglia Function through Differential Neural Pathways.
Y. Yasoshima, N. Kai, S. Yoshida, S. Shiosaka, Y. Koyama, Y. Kayama, and K. Kobayashi (2005)
J. Neurosci. 25, 7743-7753
   Abstract »    Full Text »    PDF »
Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson's Disease and Normal Macaque.
P. A. Starr, G. M. Rau, V. Davis, W. J. Marks Jr., J. L. Ostrem, D. Simmons, N. Lindsey, and R. S. Turner (2005)
J Neurophysiol 93, 3165-3176
   Abstract »    Full Text »    PDF »
Pallidal Origin of GABA Release within the Substantia Nigra Pars Reticulata during High-Frequency Stimulation of the Subthalamic Nucleus.
F. Windels, C. Carcenac, A. Poupard, and M. Savasta (2005)
J. Neurosci. 25, 5079-5086
   Abstract »    Full Text »    PDF »
Targeting the subthalamic nucleus for deep brain stimulation: technical approach and fusion of pre- and postoperative MR images to define accuracy of lead placement.
N A Hamid, R D Mitchell, P Mocroft, G W M Westby, J Milner, and H Pall (2005)
J. Neurol. Neurosurg. Psychiatry 76, 409-414
   Abstract »    Full Text »    PDF »
Bilateral subthalamotomy in Parkinson's disease: initial and long-term response.
L. Alvarez, R. Macias, G. Lopez, E. Alvarez, N. Pavon, M. C. Rodriguez-Oroz, J. L. Juncos, C. Maragoto, J. Guridi, I. Litvan, et al. (2005)
Brain 128, 570-583
   Abstract »    Full Text »    PDF »
Effects of subthalamic nucleus stimulation and medication on resting and postural tremor in Parkinson's disease.
M. M. Sturman, D. E. Vaillancourt, L. V. Metman, R. A. E. Bakay, and D. M. Corcos (2004)
Brain 127, 2131-2143
   Abstract »    Full Text »    PDF »
Role of External Pallidal Segment in Primate Parkinsonism: Comparison of the Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism and Lesions of the External Pallidal Segment.
J. Soares, M. A. Kliem, R. Betarbet, J. T. Greenamyre, B. Yamamoto, and T. Wichmann (2004)
J. Neurosci. 24, 6417-6426
   Abstract »    Full Text »    PDF »
Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson's disease.
K Dujardin, S Blairy, L Defebvre, P Krystkowiak, U Hess, S Blond, and A Destee (2004)
J. Neurol. Neurosurg. Psychiatry 75, 202-208
   Abstract »    Full Text »    PDF »
Effects of High-Frequency Stimulation on Subthalamic Neuronal Activity in Parkinsonian Patients.
M.-L. Welter, J.-L. Houeto, A.-M. Bonnet, P.-B. Bejjani, V. Mesnage, D. Dormont, S. Navarro, P. Cornu, Y. Agid, and B. Pidoux (2004)
Arch Neurol 61, 89-96
   Abstract »    Full Text »    PDF »
The subthalamic nucleus in the context of movement disorders.
C. Hamani, J. A. Saint-Cyr, J. Fraser, M. Kaplitt, and A. M. Lozano (2004)
Brain 127, 4-20
   Abstract »    Full Text »    PDF »
Involvement of the human subthalamic nucleus in movement preparation.
G. Paradiso, J. A. Saint-Cyr, A. M. Lozano, A. E. Lang, and R. Chen (2003)
Neurology 61, 1538-1545
   Abstract »    Full Text »    PDF »
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
K.-Z. Shen and S. W Johnson (2003)
J. Physiol. 553, 489-496
   Abstract »    Full Text »    PDF »
Spontaneous and Evoked Activity of Substantia Nigra Pars Reticulata Neurons during High-Frequency Stimulation of the Subthalamic Nucleus.
N. Maurice, A.-M. Thierry, J. Glowinski, and J.-M. Deniau (2003)
J. Neurosci. 23, 9929-9936
   Abstract »    Full Text »    PDF »
Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata.
C.-H. TAI, T. BORAUD, E. BEZARD, B. BIOULAC, C. GROSS, and A. BENAZZOUZ (2003)
FASEB J 17, 1820-1830
   Abstract »    Full Text »    PDF »
300-Hz subthalamic oscillations in Parkinson's disease.
G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K. A. Moxon, S. Cerutti, and S. Barbieri (2003)
Brain 126, 2153-2163
   Abstract »    Full Text »    PDF »
Dual Effect of High-Frequency Stimulation on Subthalamic Neuron Activity.
L. Garcia, J. Audin, G. D'Alessandro, B. Bioulac, and C. Hammond (2003)
J. Neurosci. 23, 8743-8751
   Abstract »    Full Text »    PDF »
Present and future directions in the management of motor complications in patients with advanced PD.
C. W. Olanow (2003)
Neurology 61, S24-33
   Full Text »
Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: evaluation of active electrode contacts.
W Hamel, U Fietzek, A Morsnowski, B Schrader, J Herzog, D Weinert, G Pfister, D Muller, J Volkmann, G Deuschl, et al. (2003)
J. Neurol. Neurosurg. Psychiatry 74, 1036-1046
   Abstract »    Full Text »    PDF »
Functional Disconnection of the Medial Prefrontal Cortex and Subthalamic Nucleus in Attentional Performance: Evidence for Corticosubthalamic Interaction.
Y. Chudasama, C. Baunez, and T. W. Robbins (2003)
J. Neurosci. 23, 5477-5485
   Abstract »    Full Text »    PDF »
Unilateral subthalamotomy in the treatment of Parkinson's disease.
N. K. Patel, P. Heywood, K. O'Sullivan, R. McCarter, S. Love, and S. S. Gill (2003)
Brain 126, 1136-1145
   Abstract »    Full Text »    PDF »
Stimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons.
T. Hashimoto, C. M. Elder, M. S. Okun, S. K. Patrick, and J. L. Vitek (2003)
J. Neurosci. 23, 1916-1923
   Abstract »    Full Text »    PDF »
Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease.
F. Schneider, U. Habel, J. Volkmann, S. Regel, J. Kornischka, V. Sturm, and H.-J. Freund (2003)
Arch Gen Psychiatry 60, 296-302
   Abstract »    Full Text »    PDF »
Deep brain stimulation of the subthalamic nucleus: effectiveness in advanced Parkinson's disease patients previously reliant on apomorphine.
T R K Varma, S H Fox, P R Eldridge, P Littlechild, P Byrne, A Forster, A Marshall, H Cameron, K McIver, N Fletcher, et al. (2003)
J. Neurol. Neurosurg. Psychiatry 74, 170-174
   Abstract »    Full Text »    PDF »
Oral Pharmacotherapy of Childhood Movement Disorders.
T. S. Edgar (2003)
J Child Neurol 18, S40-S49
   Abstract »    PDF »
Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus.
D. Nandi, T. Z. Aziz, N. Giladi, J. Winter, and J. F. Stein (2002)
Brain 125, 2418-2430
   Abstract »    Full Text »    PDF »
The Switch of Subthalamic Neurons From an Irregular to a Bursting Pattern Does Not Solely Depend on Their GABAergic Inputs in the Anesthetic-Free Rat.
N. Urbain, N. Rentero, D. Gervasoni, B. Renaud, and G. Chouvet (2002)
J. Neurosci. 22, 8665-8675
   Abstract »    Full Text »    PDF »
Behavioral Consequences of Bicuculline Injection in the Subthalamic Nucleus and the Zona Incerta in Rat.
C. Perier, L. Tremblay, J. Feger, and E. C. Hirsch (2002)
J. Neurosci. 22, 8711-8719
   Abstract »    Full Text »    PDF »
Consequences of Dopaminergic Denervation on the Metabolic Activity of the Cortical Neurons Projecting to the Subthalamic Nucleus in the Rat.
G. Orieux, C. Francois, J. Feger, and E. C. Hirsch (2002)
J. Neurosci. 22, 8762-8770
   Abstract »    Full Text »    PDF »
Subthalamic nucleus stimulation affects striato-anterior cingulate cortex circuit in a response conflict task: a PET study.
U. Schroeder, A. Kuehler, B. Haslinger, P. Erhard, W. Fogel, V. M. Tronnier, K. W. Lange, H. Boecker, and A. O. Ceballos-Baumann (2002)
Brain 125, 1995-2004
   Abstract »    Full Text »    PDF »
Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism.
N. Breysse, C. Baunez, W. Spooren, F. Gasparini, and M. Amalric (2002)
J. Neurosci. 22, 5669-5678
   Abstract »    Full Text »    PDF »
D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Results from a Switch in the Regulation of ERK1/2/MAP Kinase.
C. R. Gerfen, S. Miyachi, R. Paletzki, and P. Brown (2002)
J. Neurosci. 22, 5042-5054
   Abstract »    Full Text »    PDF »
High-Frequency Stimulation of the Subthalamic Nucleus Selectively Reverses Dopamine Denervation-Induced Cellular Defects in the Output Structures of the Basal Ganglia in the Rat.
P. Salin, C. Manrique, C. Forni, and L. K.-L. Goff (2002)
J. Neurosci. 22, 5137-5148
   Abstract »    Full Text »    PDF »
Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's disease.
D. Cunic, L. Roshan, F. I. Khan, A. M. Lozano, A. E. Lang, and R. Chen (2002)
Neurology 58, 1665-1672
   Abstract »    Full Text »    PDF »
Environment, Mitochondria, and Parkinson's Disease.
T. B. Sherer, R. Betarbet, and J. T. Greenamyre (2002)
Neuroscientist 8, 192-197
   Abstract »    PDF »
The Globus Pallidus, Deep Brain Stimulation, and Parkinson's Disease.
J. O. Dostrovsky, W. D. Hutchison, and A. M. Lozano (2002)
Neuroscientist 8, 284-290
   Abstract »    PDF »
Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease.
R. Levy, P. Ashby, W. D. Hutchison, A. E. Lang, A. M. Lozano, and J. O. Dostrovsky (2002)
Brain 125, 1196-1209
   Abstract »    Full Text »    PDF »
Evidence of thalamic disinhibition in patients with hemichorea: semiquantitative analysis using SPECT.
J-S Kim, K-S Lee, K-H Lee, Y-I Kim, B-S Kim, Y-A Chung, and S-K Chung (2002)
J. Neurol. Neurosurg. Psychiatry 72, 329-333
   Abstract »    Full Text »    PDF »
Distinct Roles for Nigral GABA and Glutamate Receptors in the Regulation of Dendritic Dopamine Release under Normal Conditions and in Response to Systemic Haloperidol.
W. S. Cobb and E. D. Abercrombie (2002)
J. Neurosci. 22, 1407-1413
   Abstract »    Full Text »    PDF »
Enhanced Food-Related Motivation after Bilateral Lesions of the Subthalamic Nucleus.
C. Baunez, M. Amalric, and T. W. Robbins (2002)
J. Neurosci. 22, 562-568
   Abstract »    Full Text »    PDF »
Effects of Transient Focal Inactivation of the Basal Ganglia in Parkinsonian Primates.
M. S. Baron, T. Wichmann, D. Ma, and M. R. DeLong (2002)
J. Neurosci. 22, 592-599
   Abstract »    Full Text »    PDF »
The cerebral oscillatory network of parkinsonian resting tremor.
L. Timmermann, J. Gross, M. Dirks, J. Volkmann, H.-J. Freund, and A. Schnitzler (2002)
Brain 126, 199-212
   Abstract »    Full Text »    PDF »
Surgical Treatment of Parkinson Disease.
E. N. Eskandar, G. R. Cosgrove, and L. A. Shinobu (2001)
JAMA 286, 3056-3059
   Full Text »    PDF »
Lidocaine and muscimol microinjections in subthalamic nucleus reverse parkinsonian symptoms.
R. Levy, A. E. Lang, J. O. Dostrovsky, P. Pahapill, J. Romas, J. Saint-Cyr, W. D. Hutchison, and A. M. Lozano (2001)
Brain 124, 2105-2118
   Abstract »    Full Text »    PDF »
Deep-Brain Stimulation of the Subthalamic Nucleus or the Pars Interna of the Globus Pallidus in Parkinson's Disease.
The Deep-Brain Stimulation for Parkinson's Disease (2001)
N. Engl. J. Med. 345, 956-963
   Abstract »    Full Text »    PDF »
The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics.
M. C. Rodriguez-Oroz, M. Rodriguez, J. Guridi, K. Mewes, V. Chockkman, J. Vitek, M. R. DeLong, and J. A. Obeso (2001)
Brain 124, 1777-1790
   Abstract »    Full Text »    PDF »
Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism.
K. A. Mooslehner, P. M. Chan, W. Xu, L. Liu, C. Smadja, T. Humby, N. D. Allen, L. S. Wilkinson, and P. C. Emson (2001)
Mol. Cell. Biol. 21, 5321-5331
   Abstract »    Full Text »    PDF »
Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: effects of variation in stimulation parameters.
M Rizzone, M Lanotte, B Bergamasco, A Tavella, E Torre, G Faccani, A Melcarne, and L Lopiano (2001)
J. Neurol. Neurosurg. Psychiatry 71, 215-219
   Abstract »    Full Text »    PDF »
Effects of Apomorphine on Subthalamic Nucleus and Globus Pallidus Internus Neurons in Patients With Parkinson's Disease.
R. Levy, J. O. Dostrovsky, A. E. Lang, E. Sime, W. D. Hutchison, and A. M. Lozano (2001)
J Neurophysiol 86, 249-260
   Abstract »    Full Text »    PDF »
An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment.
C. W. Olanow, R. L. Watts, and W. C. Koller (2001)
Neurology 56, S1-S88
   Full Text »    PDF »
Enhancement of Sensorimotor Behavioral Recovery in Hemiparkinsonian Rats with Intrastriatal, Intranigral, and Intrasubthalamic Nucleus Dopaminergic Transplants.
K. Mukhida, K. A. Baker, D. Sadi, and I. Mendez (2001)
J. Neurosci. 21, 3521-3530
   Abstract »    Full Text »    PDF »
Activation of Group III mGluRs Inhibits GABAergic and Glutamatergic Transmission in the Substantia Nigra Pars Reticulata.
M. Wittmann, M. J. Marino, S. R. Bradley, and P. J. Conn (2001)
J Neurophysiol 85, 1960-1968
   Abstract »    Full Text »    PDF »
Deep brain stimulation for the treatment of Parkinson's disease: subthalamic nucleus versus globus pallidus internus.
M Krause, W Fogel, A Heck, W Hacke, M Bonsanto, C Trenkwalder, and V Tronnier (2001)
J. Neurol. Neurosurg. Psychiatry 70, 464-470
   Abstract »    Full Text »    PDF »
Selective Dopamine Receptor Stimulation Differentially Affects [3H]Arachidonic Acid Incorporation, a Surrogate Marker for Phospholipase A2-Mediated Neurotransmitter Signal Transduction, in a Rodent Model of Parkinson's Disease.
T. Hayakawa, M. C. J. Chang, S. I. Rapoport, and N. M. Appel (2001)
J. Pharmacol. Exp. Ther. 296, 1074-1084
   Abstract »    Full Text »
A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease.
(2001)
Neurology 56, 455-462
   Abstract »    Full Text »    PDF »
The subthalamic nucleus, hemiballismus and Parkinson's disease: reappraisal of a neurosurgical dogma.
J. Guridi and J. A. Obeso (2001)
Brain 124, 5-19
   Abstract »    Full Text »    PDF »
Firing Patterns and Correlations of Spontaneous Discharge of Pallidal Neurons in the Normal and the Tremulous 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Vervet Model of Parkinsonism.
A. Raz, E. Vaadia, and H. Bergman (2000)
J. Neurosci. 20, 8559-8571
   Abstract »    Full Text »    PDF »
High-frequency Synchronization of Neuronal Activity in the Subthalamic Nucleus of Parkinsonian Patients with Limb Tremor.
R. Levy, W. D. Hutchison, A. M. Lozano, and J. O. Dostrovsky (2000)
J. Neurosci. 20, 7766-7775
   Abstract »    Full Text »    PDF »
Low-Affinity Blockade of Neuronal N-Type Ca Channels by the Spider Toxin omega -Agatoxin-IVA.
S. S. Sidach and I. M. Mintz (2000)
J. Neurosci. 20, 7174-7182
   Abstract »    Full Text »    PDF »
A Kv3-like persistent, outwardly rectifying, Cs+-permeable, K+ current in rat subthalamic nucleus neurones.
M. A Wigmore and M. G Lacey (2000)
J. Physiol. 527, 493-506
   Abstract »    Full Text »    PDF »
The pedunculopontine nucleus and Parkinson's disease.
P. A. Pahapill and A. M. Lozano (2000)
Brain 123, 1767-1783
   Abstract »    Full Text »    PDF »
Postural and Anticonvulsant Effects of Inhibition of the Rat Subthalamic Nucleus.
D. Dybdal and K. Gale (2000)
J. Neurosci. 20, 6728-6733
   Abstract »    Full Text »    PDF »
Levodopa Withdrawal After Bilateral Subthalamic Nucleus Stimulation in Advanced Parkinson Disease.
J. L. Molinuevo, F. Valldeoriola, E. Tolosa, J. Rumia, J. Valls-Sole, H. Roldan, and E. Ferrer (2000)
Arch Neurol 57, 983-988
   Abstract »    Full Text »    PDF »
Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.
P. Krack, P. L. Dowsey, A. L. Benabid, N. Acarin, A. Benazzouz, G. Kunig, K. L. Leenders, J. A. Obeso, and P. Pollak (2000)
Neurology 54, 2182-2184
   Abstract »    Full Text »    PDF »
The impact of deep brain stimulation on executive function in Parkinson's disease.
M. Jahanshahi, C. M. A. Ardouin, R. G. Brown, J. C. Rothwell, J. Obeso, A. Albanese, M. C. Rodriguez-Oroz, E. Moro, A. L. Benabid, P. Pollak, et al. (2000)
Brain 123, 1142-1154
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)