Science 21 September 1990: Vol. 249. no. 4975, pp. 1431 - 1433 DOI: 10.1126/science.1698311

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Articles

Nonhemopoietic Cell TLR4 Signaling Is Critical in Causing Early Lipopolysaccharide-Induced Ileus.

B. M. Buchholz, R. S. Chanthaphavong, and A. J. M. Bauer (2009)
J. Immunol. 183, 6744-6753
 |  Abstract »  |  Full Text »  |  PDF »

The Gene History of Zebrafish tlr4a and tlr4b Is Predictive of Their Divergent Functions.

C. Sullivan, J. Charette, J. Catchen, C. R. Lage, G. Giasson, J. H. Postlethwait, P. J. Millard, and C. H. Kim (2009)
J. Immunol. 183, 5896-5908
 |  Abstract »  |  Full Text »  |  PDF »

Novel Roles of Lysines 122, 125, and 58 in Functional Differences between Human and Murine MD-2.

J. Vasl, A. Oblak, T. L. Gioannini, J. P. Weiss, and R. Jerala (2009)
J. Immunol. 183, 5138-5145
 |  Abstract »  |  Full Text »  |  PDF »

Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88.

J. Yang, Y. H. Ryu, C.-H. Yun, and S. H. Han (2009)
J. Leukoc. Biol. 86, 823-831
 |  Abstract »  |  Full Text »  |  PDF »

Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2.

K. Kuronuma, H. Mitsuzawa, K. Takeda, C. Nishitani, E. D. Chan, Y. Kuroki, M. Nakamura, and D. R. Voelker (2009)
J. Biol. Chem. 284, 25488-25500
 |  Abstract »  |  Full Text »  |  PDF »

TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain.

S. Carpenter, T. Carlson, J. Dellacasagrande, A. Garcia, S. Gibbons, P. Hertzog, A. Lyons, L.-L. Lin, M. Lynch, T. Monie, et al. (2009)
J. Immunol. 183, 3989-3995
 |  Abstract »  |  Full Text »  |  PDF »

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4.

P. G. Motshwene, M. C. Moncrieffe, J. G. Grossmann, C. Kao, M. Ayaluru, A. M. Sandercock, C. V. Robinson, E. Latz, and N. J. Gay (2009)
J. Biol. Chem. 284, 25404-25411
 |  Abstract »  |  Full Text »  |  PDF »

The Association with the -159C/T Polymorphism in the Promoter Region of the CD14 Gene and Juvenile Idiopathic Arthritis in a Chinese Han Population.

H. S. ZENG, X. Y. CHEN, and X. P. LUO (2009)
J Rheumatol 36, 2025-2028
 |  Abstract »  |  Full Text »  |  PDF »

CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages.

C. Oliva, C. L. Turnbough Jr., and J. F. Kearney (2009)
PNAS 106, 13957-13962
 |  Abstract »  |  Full Text »  |  PDF »

Variable Cell Responses to P. gingivalis Lipopolysaccharide.

L. Kocgozlu, R. Elkaim, H. Tenenbaum, and S. Werner (2009)
Journal of Dental Research 88, 741-745
 |  Abstract »  |  Full Text »  |  PDF »

Mutational analysis of Cys88 of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.

C. Nishitani, M. Takahashi, H. Mitsuzawa, T. Shimizu, S. Ariki, N. Matsushima, and Y. Kuroki (2009)
Int. Immunol. 21, 925-934
 |  Abstract »  |  Full Text »  |  PDF »

The Antifungal Agent Itraconazole Induces the Accumulation of High Mannose Glycoproteins in Macrophages.

T. Frey and A. De Maio (2009)
J. Biol. Chem. 284, 16882-16890
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway.

G. Zhang, J. Han, E. J. Welch, R. D. Ye, T. A. Voyno-Yasenetskaya, A. B. Malik, X. Du, and Z. Li (2009)
J. Immunol. 182, 7997-8004
 |  Abstract »  |  Full Text »  |  PDF »

Myeloid Differentiation Protein-2-Dependent and -Independent Neutrophil Accumulation during Escherichia coli Pneumonia.

S. Cai, R. L. Zemans, S. K. Young, G. S. Worthen, and S. Jeyaseelan (2009)
Am. J. Respir. Cell Mol. Biol. 40, 701-709
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer.

L. A. J. O'Neill, C. E. Bryant, and S. L. Doyle (2009)
Pharmacol. Rev. 61, 177-197
 |  Abstract »  |  Full Text »  |  PDF »

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin.

N. Resman, J. Vasl, A. Oblak, P. Pristovsek, T. L. Gioannini, J. P. Weiss, and R. Jerala (2009)
J. Biol. Chem. 284, 15052-15060
 |  Abstract »  |  Full Text »  |  PDF »

Trappin-2 Promotes Early Clearance of Pseudomonas aeruginosa through CD14-Dependent Macrophage Activation and Neutrophil Recruitment.

T. S. Wilkinson, K. Dhaliwal, T. W. Hamilton, A. F. Lipka, L. Farrell, D. J. Davidson, R. Duffin, A. C. Morris, C. Haslett, J. R.W. Govan, et al. (2009)
Am. J. Pathol. 174, 1338-1346
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease.

R. Das, X. Chen, R. Komorowski, M. J. Hessner, and W. R. Drobyski (2009)
Blood 113, 2352-2362
 |  Abstract »  |  Full Text »  |  PDF »

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4.

T. Roger, C. Froidevaux, D. Le Roy, M. K. Reymond, A.-L. Chanson, D. Mauri, K. Burns, B. M. Riederer, S. Akira, and T. Calandra (2009)
PNAS 106, 2348-2352
 |  Abstract »  |  Full Text »  |  PDF »

TLRs and innate immunity.

B. A. Beutler (2009)
Blood 113, 1399-1407
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-binding protein and CD14 are increased in the bronchoalveolar lavage fluid of smokers.

V. Regueiro, M. A. Campos, P. Morey, J. Sauleda, A.G.N. Agusti, J. Garmendia, and J. A. Bengoechea (2009)
Eur. Respir. J. 33, 273-281
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Complement and CD14 Attenuates the Escherichia coli-Induced Inflammatory Response in Porcine Whole Blood.

E. B. Thorgersen, A. Pharo, K. Haverson, A. K. Axelsen, P. Gaustad, G. J. Kotwal, G. Sfyroera, and T. E. Mollnes (2009)
Infect. Immun. 77, 725-732
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Defensin-2 Promotes Resistance against Infection with P. aeruginosa.

M. Wu, S. A. McClellan, R. P. Barrett, and L. D. Hazlett (2009)
J. Immunol. 182, 1609-1616
 |  Abstract »  |  Full Text »  |  PDF »

Airway Epithelial Cells Regulate the Functional Phenotype of Locally Differentiating Dendritic Cells: Implications for the Pathogenesis of Infectious and Allergic Airway Disease.

A. Rate, J. W. Upham, A. Bosco, K. L. McKenna, and P. G. Holt (2009)
J. Immunol. 182, 72-83
 |  Abstract »  |  Full Text »  |  PDF »

Milk Fat Globule Epidermal Growth Factor-Factor VIII Is Down-Regulated in Sepsis via the Lipopolysaccharide-CD14 Pathway.

H. Komura, M. Miksa, R. Wu, S. M. Goyert, and P. Wang (2009)
J. Immunol. 182, 581-587
 |  Abstract »  |  Full Text »  |  PDF »

LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction.

R. M. Minter, X. Bi, G. Ben-Josef, T. Wang, B. Hu, S. Arbabi, M. R. Hemmila, S. C. Wang, D. G. Remick, and G. L. Su (2009)
Am J Physiol Gastrointest Liver Physiol 296, G45-G54
 |  Abstract »  |  Full Text »  |  PDF »

Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart.

W. Chao (2009)
Am J Physiol Heart Circ Physiol 296, H1-H12
 |  Abstract »  |  Full Text »  |  PDF »

Neutrophil Chemotaxis and Local Expression of Interleukin-10 in the Tolerance of Endotoxin-Induced Uveitis.

H. Mashimo, N. Ohguro, S. Nomura, N. Hashida, K. Nakai, and Y. Tano (2008)
Invest. Ophthalmol. Vis. Sci. 49, 5450-5457
 |  Abstract »  |  Full Text »  |  PDF »

Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense.

S. Hansdottir, M. M. Monick, S. L. Hinde, N. Lovan, D. C. Look, and G. W. Hunninghake (2008)
J. Immunol. 181, 7090-7099
 |  Abstract »  |  Full Text »  |  PDF »

A Phosphatidylserine Species Inhibits a Range of TLR- but Not IL-1{beta}-Induced Inflammatory Responses by Disruption of Membrane Microdomains.

L. C. Parker, E. C. Prestwich, J. R. Ward, E. Smythe, A. Berry, M. Triantafilou, K. Triantafilou, and I. Sabroe (2008)
J. Immunol. 181, 5606-5617
 |  Abstract »  |  Full Text »  |  PDF »

Animal models of acute lung injury.

G. Matute-Bello, C. W. Frevert, and T. R. Martin (2008)
Am J Physiol Lung Cell Mol Physiol 295, L379-L399
 |  Abstract »  |  Full Text »  |  PDF »

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo.

M. K. Chang, L.-J. Raggatt, K. A. Alexander, J. S. Kuliwaba, N. L. Fazzalari, K. Schroder, E. R. Maylin, V. M. Ripoll, D. A. Hume, and A. R. Pettit (2008)
J. Immunol. 181, 1232-1244
 |  Abstract »  |  Full Text »  |  PDF »

Varying Importance of Soluble and Membrane CD14 in Endothelial Detection of Lipopolysaccharide.

K. L. Lloyd-Jones, M. M. Kelly, and P. Kubes (2008)
J. Immunol. 181, 1446-1453
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Plasma Phospholipid Transfer Protein Deficiency on Lethal Endotoxemia in Mice.

T. Gautier, A. Klein, V. Deckert, C. Desrumaux, N. Ogier, A.-L. Sberna, C. Paul, N. Le Guern, A. Athias, T. Montange, et al. (2008)
J. Biol. Chem. 283, 18702-18710
 |  Abstract »  |  Full Text »  |  PDF »

A Cyanobacterial Lipopolysaccharide Antagonist Inhibits Cytokine Production Induced by Neisseria meningitidis in a Human Whole-Blood Model of Septicemia.

K. Jemmett, A. Macagno, M. Molteni, J. E. Heckels, C. Rossetti, and M. Christodoulides (2008)
Infect. Immun. 76, 3156-3163
 |  Abstract »  |  Full Text »  |  PDF »

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36.

N. J. Nilsen, S. Deininger, U. Nonstad, F. Skjeldal, H. Husebye, D. Rodionov, S. von Aulock, T. Hartung, E. Lien, O. Bakke, et al. (2008)
J. Leukoc. Biol. 84, 280-291
 |  Abstract »  |  Full Text »  |  PDF »

Functional Activity of MD-2 Polymorphic Variant Is Significantly Different in Soluble and TLR4-Bound Forms: Decreased Endotoxin Binding by G56R MD-2 and Its Rescue by TLR4 Ectodomain.

J. Vasl, P. Prohinar, T. L. Gioannini, J. P. Weiss, and R. Jerala (2008)
J. Immunol. 180, 6107-6115
 |  Abstract »  |  Full Text »  |  PDF »

Murine {beta}-defensin 2 promotes TLR-4/MyD88-mediated and NF-{kappa}B-dependent atypical death of APCs via activation of TNFR2.

A. Biragyn, M. Coscia, K. Nagashima, M. Sanford, H. A. Young, and P. Olkhanud (2008)
J. Leukoc. Biol. 83, 998-1008
 |  Abstract »  |  Full Text »  |  PDF »

Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock.

Y. Ren, Y. Xie, G. Jiang, J. Fan, J. Yeung, W. Li, P. K. H. Tam, and J. Savill (2008)
J. Immunol. 180, 4978-4985
 |  Abstract »  |  Full Text »  |  PDF »

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-{alpha} Production in Human Monocytes.

J. H. Youn, Y. J. Oh, E. S. Kim, J. E. Choi, and J.-S. Shin (2008)
J. Immunol. 180, 5067-5074
 |  Abstract »  |  Full Text »  |  PDF »

Gut Microbiota and Its Possible Relationship With Obesity.

J. K. DiBaise, H. Zhang, M. D. Crowell, R. Krajmalnik-Brown, G. A. Decker, and B. E. Rittmann (2008)
Mayo Clin. Proc. 83, 460-469
 |  Abstract »  |  Full Text »  |  PDF »

Early events in the recognition of danger signals after tissue injury.

D. J. Kaczorowski, K. P. Mollen, R. Edmonds, and T. R. Billiar (2008)
J. Leukoc. Biol. 83, 546-552
 |  Abstract »  |  Full Text »  |  PDF »

Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.

K. Farhat, S. Riekenberg, H. Heine, J. Debarry, R. Lang, J. Mages, U. Buwitt-Beckmann, K. Roschmann, G. Jung, K.-H. Wiesmuller, et al. (2008)
J. Leukoc. Biol. 83, 692-701
 |  Abstract »  |  Full Text »  |  PDF »

Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor.

S. Knapp, S. von Aulock, M. Leendertse, I. Haslinger, C. Draing, D. T. Golenbock, and T. van der Poll (2008)
J. Immunol. 180, 3478-3484
 |  Abstract »  |  Full Text »  |  PDF »

Role of NF-{kappa}B-dependent Caveolin-1 Expression in the Mechanism of Increased Endothelial Permeability Induced by Lipopolysaccharide.

C. Tiruppathi, J. Shimizu, K. Miyawaki-Shimizu, S. M. Vogel, A. M. Bair, R. D. Minshall, D. Predescu, and A. B. Malik (2008)
J. Biol. Chem. 283, 4210-4218
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation.

J. W. Chien, M. J. Boeckh, J. A. Hansen, and J. G. Clark (2008)
Blood 111, 2462-2469
 |  Abstract »  |  Full Text »  |  PDF »

Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria.

P. Tissieres, I. Dunn-Siegrist, M. Schappi, G. Elson, R. Comte, V. Nobre, and J. Pugin (2008)
Blood 111, 2122-2131
 |  Abstract »  |  Full Text »  |  PDF »

The Differential Impact of Disulfide Bonds and N-Linked Glycosylation on the Stability and Function of CD14.

J. Meng, P. Parroche, D. T. Golenbock, and C. J. McKnight (2008)
J. Biol. Chem. 283, 3376-3384
 |  Abstract »  |  Full Text »  |  PDF »

Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages.

S. M. Eswarappa, N. Basu, O. Joy, and D. Chakravortty (2008)
Innate Immunity 14, 13-24
 |  Abstract »  |  PDF »

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.

W.K. E. Ip, K. Takahashi, K. J. Moore, L. M. Stuart, and R. A. B. Ezekowitz (2008)
J. Exp. Med. 205, 169-181
 |  Abstract »  |  Full Text »  |  PDF »

The Proinflammatory Cytokine Response to Chlamydia trachomatis Elementary Bodies in Human Macrophages Is Partly Mediated by a Lipoprotein, the Macrophage Infectivity Potentiator, through TLR2/TLR1/TLR6 and CD14.

S. Bas, L. Neff, M. Vuillet, U. Spenato, T. Seya, M. Matsumoto, and C. Gabay (2008)
J. Immunol. 180, 1158-1168
 |  Abstract »  |  Full Text »  |  PDF »

Use of Synthetic Derivatives To Determine the Minimal Active Structure of Cytokine-Inducing Lipoteichoic Acid.

S. Deininger, I. Figueroa-Perez, S. Sigel, A. Stadelmaier, R. R. Schmidt, T. Hartung, and S. von Aulock (2007)
Clin. Vaccine Immunol. 14, 1629-1633
 |  Abstract »  |  Full Text »  |  PDF »

Soluble CD14 Discriminates Slight Structural Differences between Lipid As That Lead to Distinct Host Cell Activation.

Y. Asai, Y. Makimura, A. Kawabata, and T. Ogawa (2007)
J. Immunol. 179, 7674-7683
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Involvement of Fc{gamma} Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1.

I. Dunn-Siegrist, O. Leger, B. Daubeuf, Y. Poitevin, F. Depis, S. Herren, M. Kosco-Vilbois, Y. Dean, J. Pugin, and G. Elson (2007)
J. Biol. Chem. 282, 34817-34827
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD14 in Responses to Clinical Isolates of Escherichia coli: Effects of K1 Capsule Expression.

S. Metkar, S. Awasthi, E. Denamur, K. S. Kim, S. C. Gangloff, S. Teichberg, A. Haziot, J. Silver, and S. M. Goyert (2007)
Infect. Immun. 75, 5415-5424
 |  Abstract »  |  Full Text »  |  PDF »

Estradiol Attenuates Lipopolysaccharide-Induced CXC Chemokine Ligand 8 Production by Human Peripheral Blood Monocytes.

P. A. Pioli, A. L. Jensen, L. K. Weaver, E. Amiel, Z. Shen, L. Shen, C. R. Wira, and P. M. Guyre (2007)
J. Immunol. 179, 6284-6290
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of two novel LPS-binding sites in leukocyte integrin {beta}A domain.

K.-F. Wong, J. M. Luk, R. H. Cheng, L. B. Klickstein, and S.-T. Fan (2007)
FASEB J 21, 3231-3239
 |  Abstract »  |  Full Text »  |  PDF »

Toll-like Receptors in Tumor Immunotherapy.

C. M. Paulos, A. Kaiser, C. Wrzesinski, C. S. Hinrichs, L. Cassard, A. Boni, P. Muranski, L. Sanchez-Perez, D. C. Palmer, Z. Yu, et al. (2007)
Clin. Cancer Res. 13, 5280-5289
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Levels of Oxidized Low-Density Lipoprotein Prime Monocytes to Cytokine Overproduction via Upregulation of CD14 and Toll-Like Receptor 4 in Unstable Angina.

A. F. Pasini, M. Anselmi, U. Garbin, E. Franchi, C. Stranieri, M.C. Nava, V. Boccioletti, C. Vassanelli, and L. Cominacini (2007)
Arterioscler Thromb Vasc Biol 27, 1991-1997
 |  Abstract »  |  Full Text »  |  PDF »

Soluble CD14 and CD83 from Human Neonatal Antigen-Presenting Cells Are Inducible by Commensal Bacteria and Suppress Allergen-Induced Human Neonatal Th2 Differentiation.

A.-C. Lundell, K. Andersson, E. Josefsson, A. Steinkasserer, and A. Rudin (2007)
Infect. Immun. 75, 4097-4104
 |  Abstract »  |  Full Text »  |  PDF »

Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men.

P. M. Lepper, C. Schumann, K. Triantafilou, F. M. Rasche, T. Schuster, H. Frank, E. M. Schneider, M. Triantafilou, and M. von Eynatten (2007)
J. Am. Coll. Cardiol. 50, 25-31
 |  Abstract »  |  Full Text »  |  PDF »

CD14 is an essential mediator of LPS-induced airway disease.

D. M. Brass, J. W. Hollingsworth, E. McElvania-Tekippe, S. Garantziotis, I. Hossain, and D. A. Schwartz (2007)
Am J Physiol Lung Cell Mol Physiol 293, L77-L83
 |  Abstract »  |  Full Text »  |  PDF »

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance.

P. D. Cani, J. Amar, M. A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A. M. Neyrinck, F. Fava, K. M. Tuohy, C. Chabo, et al. (2007)
Diabetes 56, 1761-1772
 |  Abstract »  |  Full Text »  |  PDF »

Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease.

J. A Mitchell, M. J Paul-Clark, G. W Clarke, S. K McMaster, and N. Cartwright (2007)
J. Endocrinol. 193, 323-330
 |  Abstract »  |  Full Text »  |  PDF »

Recombinant Factor C competes against LBP to bind lipopolysaccharide and neutralizes the endotoxicity.

P. Li, B. Ho, and J. L. Ding (2007)
Innate Immunity 13, 150-157
 |  Abstract »  |  PDF »

The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood.

O.-L. Brekke, D. Christiansen, H. Fure, M. Fung, and T. E. Mollnes (2007)
J. Leukoc. Biol. 81, 1404-1413
 |  Abstract »  |  Full Text »  |  PDF »

Reducing the Toll of Inflammatory Lung Disease.

N. Chaudhuri, M. K. B. Whyte, and I. Sabroe (2007)
Chest 131, 1550-1556
 |  Abstract »  |  Full Text »  |  PDF »

TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness.

R. Graveline, M. Segura, D. Radzioch, and M. Gottschalk (2007)
Int. Immunol. 19, 375-389
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C{zeta} (PKC{zeta}) Regulates Ocular Inflammation and Apoptosis in Endotoxin-Induced Uveitis (EIU): Signaling Molecules Involved in EIU Resolution by PKC{zeta} Inhibitor and Interleukin-13.

Y. de Kozak, B. Omri, J. R. Smith, M.-C. Naud, B. Thillaye-Goldenberg, and P. Crisanti (2007)
Am. J. Pathol. 170, 1241-1257
 |  Abstract »  |  Full Text »  |  PDF »

CD14 Facilitates Invasive Respiratory Tract Infection by Streptococcus pneumoniae.

M. C. Dessing, S. Knapp, S. Florquin, A. F. de Vos, and T. van der Poll (2007)
Am. J. Respir. Crit. Care Med. 175, 604-611
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Fish Oil Increases the Number of Splenic Macrophages Secreting TNF-{alpha} and IL-10 But Decreases the Secretion of These Cytokines by Splenic T Cells from Mice.

D. H. Petursdottir and I. Hardardottir (2007)
J. Nutr. 137, 665-670
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Cellular Basis of Microflora-Host Interactions.

P. Winkler, D. Ghadimi, J. Schrezenmeir, and J.-P. Kraehenbuhl (2007)
J. Nutr. 137, 756S-772S
 |  Abstract »  |  Full Text »  |  PDF »

Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-{kappa}B via I{kappa}B{alpha} Negative Regulation.

A. Majdalawieh, L. Zhang, and H.-S. Ro (2007)
Mol. Biol. Cell 18, 930-942
 |  Abstract »  |  Full Text »  |  PDF »

CD44 Is a Negative Regulator of Acute Pulmonary Inflammation and Lipopolysaccharide-TLR Signaling in Mouse Macrophages.

J. Liang, D. Jiang, J. Griffith, S. Yu, J. Fan, X. Zhao, R. Bucala, and P. W. Noble (2007)
J. Immunol. 178, 2469-2475
 |  Abstract »  |  Full Text »  |  PDF »

Oxidized Phospholipids Inhibit Phagocytosis and Impair Outcome in Gram-Negative Sepsis In Vivo.

S. Knapp, U. Matt, N. Leitinger, and T. van der Poll (2007)
J. Immunol. 178, 993-1001
 |  Abstract »  |  Full Text »  |  PDF »

Toll-like Receptor 4 Region Glu24-Lys47 Is a Site for MD-2 Binding: IMPORTANCE OF CYS29 AND CYS40.

C. Nishitani, H. Mitsuzawa, H. Sano, T. Shimizu, N. Matsushima, and Y. Kuroki (2006)
J. Biol. Chem. 281, 38322-38329
 |  Abstract »  |  Full Text »  |  PDF »

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).

A. Visintin, K. A. Halmen, N. Khan, B. G. Monks, D. T. Golenbock, and E. Lien (2006)
J. Leukoc. Biol. 80, 1584-1592
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Recombinant Soluble Forms of Extracellular TLR4 Domain and MD-2 Inhibit Lipopolysaccharide Binding on Cell Surface and Dampen Lipopolysaccharide-Induced Pulmonary Inflammation in Mice.

H. Mitsuzawa, C. Nishitani, N. Hyakushima, T. Shimizu, H. Sano, N. Matsushima, K. Fukase, and Y. Kuroki (2006)
J. Immunol. 177, 8133-8139
 |  Abstract »  |  Full Text »  |  PDF »

Cell Activation of Human Macrophages by Lipoteichoic Acid Is Strongly Attenuated by Lipopolysaccharide-binding Protein.

M. Mueller, C. Stamme, C. Draing, T. Hartung, U. Seydel, and A. B. Schromm (2006)
J. Biol. Chem. 281, 31448-31456
 |  Abstract »  |  Full Text »  |  PDF »

Cellular reprogramming by gram-positive bacterial components: a review.

J. M. Buckley, J. H. Wang, and H. P. Redmond (2006)
J. Leukoc. Biol. 80, 731-741
 |  Abstract »  |  Full Text »  |  PDF »

Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4.

R. M. Levy, J. M. Prince, R. Yang, K. P. Mollen, H. Liao, G. A. Watson, M. P. Fink, Y. Vodovotz, and T. R. Billiar (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R970-R976
 |  Abstract »  |  Full Text »  |  PDF »

MaxiK Blockade Selectively Inhibits the Lipopolysaccharide-Induced I{kappa}B-{alpha}/NF-{kappa}B Signaling Pathway in Macrophages.

M. Papavlassopoulos, C. Stamme, L. Thon, D. Adam, D. Hillemann, U. Seydel, and A. B. Schromm (2006)
J. Immunol. 177, 4086-4093
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Characterization of the Nuclear Factor-{kappa}B Responsiveness of the Human dio2 Gene.

A. Zeold, M. Doleschall, M. C. Haffner, L. P. Capelo, J. Menyhert, Z. Liposits, W. S. da Silva, A. C. Bianco, I. Kacskovics, C. Fekete, et al. (2006)
Endocrinology 147, 4419-4429
 |  Abstract »  |  Full Text »  |  PDF »

Association of CD14 Promoter Polymorphism with Otitis Media and Pneumococcal Vaccine Responses..

S. P. Wiertsema, S.-K. Khoo, G. Baynam, R. H. Veenhoven, I. A. Laing, G. A. Zielhuis, G. T. Rijkers, J. Goldblatt, P. N. LeSouef, and E. A. M. Sanders (2006)
Clin. Vaccine Immunol. 13, 892-897
 |  Abstract »  |  Full Text »  |  PDF »

Invited review: Roles for accessory molecules in microbial recognition by Toll-like receptors.

K. Miyake (2006)
Innate Immunity 12, 195-204
 |  Abstract »  |  PDF »

ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space.

A. Basit, J. Reutershan, M. A. Morris, M. Solga, C. E. Rose Jr., and K. Ley (2006)
Am J Physiol Lung Cell Mol Physiol 291, L200-L207
 |  Abstract »  |  Full Text »  |  PDF »

GPI-linked endothelial CD14 contributes to the detection of LPS.

K. L. Lloyd and P. Kubes (2006)
Am J Physiol Heart Circ Physiol 291, H473-H481
 |  Abstract »  |  Full Text »  |  PDF »

Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes and Collagen Accumulation in Osteoblastic Cells.

T. Ichikawa, K. Horie-Inoue, K. Ikeda, B. Blumberg, and S. Inoue (2006)
J. Biol. Chem. 281, 16927-16934
 |  Abstract »  |  Full Text »  |  PDF »

Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease.

A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel (2006)
Innate Immunity 12, 133-150
 |  Abstract »  |  PDF »

Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses..

M. F. de Buhr, M. Mahler, R. Geffers, W. Hansen, A. M. Westendorf, J. Lauber, J. Buer, B. Schlegelberger, H. J. Hedrich, and A. Bleich (2006)
Physiol Genomics 25, 426-434
 |  Abstract »  |  Full Text »  |  PDF »

Chemical Modification of Santonin into a Diacetoxy Acetal Form Confers the Ability to Induce Differentiation of Human Promyelocytic Leukemia Cells via the Down-regulation of NF-{kappa}B DNA Binding Activity.

S. H. Kim, J. H. Song, B. G. Choi, H.-J. Kim, and T. S. Kim (2006)
J. Biol. Chem. 281, 13117-13125
 |  Abstract »  |  Full Text »  |  PDF »

Mutational Analysis of Membrane and Soluble Forms of Human MD-2.

S. Viriyakosol, P. S. Tobias, and T. N. Kirkland (2006)
J. Biol. Chem. 281, 11955-11964
 |  Abstract »  |  Full Text »  |  PDF »

Invited review: MDP and other muropeptides direct and synergistic effects on the immune system.

S. Traub, S. von Aulock, T. Hartung, and C. Hermann (2006)
Innate Immunity 12, 69-85
 |  Abstract »  |  PDF »

Toll-like Receptors and the Eye..

F.-S. X. Yu and L. D. Hazlett (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1255-1263
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A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling.

M. Ii, N. Matsunaga, K. Hazeki, K. Nakamura, K. Takashima, T. Seya, O. Hazeki, T. Kitazaki, and Y. Iizawa (2006)
Mol. Pharmacol. 69, 1288-1295
 |  Abstract »  |  Full Text »  |  PDF »

Pulmonary Lipopolysaccharide (LPS)-Binding Protein Inhibits the LPS-Induced Lung Inflammation In Vivo..

S. Knapp, S. Florquin, D. T. Golenbock, and T. van der Poll (2006)
J. Immunol. 176, 3189-3195
 |  Abstract »  |  Full Text »  |  PDF »

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