Science 21 September 1990: Vol. 249. no. 4975, pp. 1429 - 1431 DOI: 10.1126/science.2402637

Prev | Table of Contents | Next

Articles

Mutational analysis of Cys88 of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.

C. Nishitani, M. Takahashi, H. Mitsuzawa, T. Shimizu, S. Ariki, N. Matsushima, and Y. Kuroki (2009)
Int. Immunol.
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway.

G. Zhang, J. Han, E. J. Welch, R. D. Ye, T. A. Voyno-Yasenetskaya, A. B. Malik, X. Du, and Z. Li (2009)
J. Immunol. 182, 7997-8004
 |  Abstract »  |  Full Text »  |  PDF »

The Influence of Estrogen on Hepatobiliary Osteopontin (SPP1) Expression in a Female Rodent Model of Alcoholic Steatohepatitis.

A. Banerjee, R. Rose, G. A. Johnson, R. C. Burghardt, and S. K. Ramaiah (2009)
Toxicol Pathol 37, 492-501
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer.

L. A. J. O'Neill, C. E. Bryant, and S. L. Doyle (2009)
Pharmacol. Rev. 61, 177-197
 |  Abstract »  |  Full Text »  |  PDF »

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4.

T. Roger, C. Froidevaux, D. Le Roy, M. K. Reymond, A.-L. Chanson, D. Mauri, K. Burns, B. M. Riederer, S. Akira, and T. Calandra (2009)
PNAS 106, 2348-2352
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Complement and CD14 Attenuates the Escherichia coli-Induced Inflammatory Response in Porcine Whole Blood.

E. B. Thorgersen, A. Pharo, K. Haverson, A. K. Axelsen, P. Gaustad, G. J. Kotwal, G. Sfyroera, and T. E. Mollnes (2009)
Infect. Immun. 77, 725-732
 |  Abstract »  |  Full Text »  |  PDF »

Milk Fat Globule Epidermal Growth Factor-Factor VIII Is Down-Regulated in Sepsis via the Lipopolysaccharide-CD14 Pathway.

H. Komura, M. Miksa, R. Wu, S. M. Goyert, and P. Wang (2009)
J. Immunol. 182, 581-587
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein A-II augments monocyte responses to LPS by suppressing the inhibitory activity of LPS-binding protein.

P. A. Thompson, J. F.P. Berbee, P. C.N. Rensen, and R. L. Kitchens (2008)
Innate Immunity 14, 365-374
 |  Abstract »  |  PDF »

Statins and Sepsis: Good Bullet, Disappearing Target.

R. H. Woerndle and D. L. Maxwell (2008)
J Am Osteopath Assoc 108, 486-490
 |  Abstract »  |  Full Text »  |  PDF »

Host species-specific usage of the TLR4-LPS receptor complex.

R. Lizundia, K.-S. Sauter, G. Taylor, and D. Werling (2008)
Innate Immunity 14, 223-231
 |  Abstract »  |  PDF »

Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice.

Y. Wang, X. Zhu, G. Wu, L. Shen, and B. Chen (2008)
J. Lipid Res. 49, 1640-1645
 |  Abstract »  |  Full Text »  |  PDF »

Bacteria in the Intestine, Helpful Residents or Enemies from Within?.

G. O. Canny and B. A. McCormick (2008)
Infect. Immun. 76, 3360-3373
 |  Full Text »  |  PDF »

Mild endotoxemia, NF-{kappa}B translocation, and cytokine increase during exertional heat stress in trained and untrained individuals.

G. A. Selkirk, T. M. McLellan, H. E. Wright, and S. G. Rhind (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R611-R623
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Plasma Phospholipid Transfer Protein Deficiency on Lethal Endotoxemia in Mice.

T. Gautier, A. Klein, V. Deckert, C. Desrumaux, N. Ogier, A.-L. Sberna, C. Paul, N. Le Guern, A. Athias, T. Montange, et al. (2008)
J. Biol. Chem. 283, 18702-18710
 |  Abstract »  |  Full Text »  |  PDF »

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36.

N. J. Nilsen, S. Deininger, U. Nonstad, F. Skjeldal, H. Husebye, D. Rodionov, S. von Aulock, T. Hartung, E. Lien, O. Bakke, et al. (2008)
J. Leukoc. Biol. 84, 280-291
 |  Abstract »  |  Full Text »  |  PDF »

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen.

C. Bourgeois, Z. Hao, K. Rajewsky, A. J. Potocnik, and B. Stockinger (2008)
PNAS 105, 8691-8696
 |  Abstract »  |  Full Text »  |  PDF »

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-{alpha} Production in Human Monocytes.

J. H. Youn, Y. J. Oh, E. S. Kim, J. E. Choi, and J.-S. Shin (2008)
J. Immunol. 180, 5067-5074
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation.

J. W. Chien, M. J. Boeckh, J. A. Hansen, and J. G. Clark (2008)
Blood 111, 2462-2469
 |  Abstract »  |  Full Text »  |  PDF »

Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria.

P. Tissieres, I. Dunn-Siegrist, M. Schappi, G. Elson, R. Comte, V. Nobre, and J. Pugin (2008)
Blood 111, 2122-2131
 |  Abstract »  |  Full Text »  |  PDF »

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.

W.K. E. Ip, K. Takahashi, K. J. Moore, L. M. Stuart, and R. A. B. Ezekowitz (2008)
J. Exp. Med. 205, 169-181
 |  Abstract »  |  Full Text »  |  PDF »

The Proinflammatory Cytokine Response to Chlamydia trachomatis Elementary Bodies in Human Macrophages Is Partly Mediated by a Lipoprotein, the Macrophage Infectivity Potentiator, through TLR2/TLR1/TLR6 and CD14.

S. Bas, L. Neff, M. Vuillet, U. Spenato, T. Seya, M. Matsumoto, and C. Gabay (2008)
J. Immunol. 180, 1158-1168
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Involvement of Fc{gamma} Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1.

I. Dunn-Siegrist, O. Leger, B. Daubeuf, Y. Poitevin, F. Depis, S. Herren, M. Kosco-Vilbois, Y. Dean, J. Pugin, and G. Elson (2007)
J. Biol. Chem. 282, 34817-34827
 |  Abstract »  |  Full Text »  |  PDF »

The genetic predisposition to adverse outcome after trauma.

P. V. Giannoudis, M. van Griensven, E. Tsiridis, and H. C. Pape (2007)
J Bone Joint Surg Br 89-B, 1273-1279
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Levels of Oxidized Low-Density Lipoprotein Prime Monocytes to Cytokine Overproduction via Upregulation of CD14 and Toll-Like Receptor 4 in Unstable Angina.

A. F. Pasini, M. Anselmi, U. Garbin, E. Franchi, C. Stranieri, M.C. Nava, V. Boccioletti, C. Vassanelli, and L. Cominacini (2007)
Arterioscler. Thromb. Vasc. Biol. 27, 1991-1997
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Role for the Bactericidal/Permeability Increasing Protein in Interactions of Gram-Negative Bacterial Outer Membrane Blebs with Dendritic Cells.

H. Schultz, J. Hume, D. S. Zhang, T. L. Gioannini, and J. P. Weiss (2007)
J. Immunol. 179, 2477-2484
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2.

K. R. Taylor, K. Yamasaki, K. A. Radek, A. D. Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo (2007)
J. Biol. Chem. 282, 18265-18275
 |  Abstract »  |  Full Text »  |  PDF »

Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease.

J. A Mitchell, M. J Paul-Clark, G. W Clarke, S. K McMaster, and N. Cartwright (2007)
J. Endocrinol. 193, 323-330
 |  Abstract »  |  Full Text »  |  PDF »

Recombinant Factor C competes against LBP to bind lipopolysaccharide and neutralizes the endotoxicity.

P. Li, B. Ho, and J. L. Ding (2007)
Innate Immunity 13, 150-157
 |  Abstract »  |  PDF »

The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood.

O.-L. Brekke, D. Christiansen, H. Fure, M. Fung, and T. E. Mollnes (2007)
J. Leukoc. Biol. 81, 1404-1413
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Recognition of Trimyristoylated Peptide or Enterobacterial Lipopolysaccharide via Both TLR2 and TLR4.

S. Spiller, S. Dreher, G. Meng, A. Grabiec, W. Thomas, T. Hartung, K. Pfeffer, H. Hochrein, H. Brade, W. Bessler, et al. (2007)
J. Biol. Chem. 282, 13190-13198
 |  Abstract »  |  Full Text »  |  PDF »

IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn's Disease.

K. Wolk, E. Witte, U. Hoffmann, W.-D. Doecke, S. Endesfelder, K. Asadullah, W. Sterry, H.-D. Volk, B. M. Wittig, and R. Sabat (2007)
J. Immunol. 178, 5973-5981
 |  Abstract »  |  Full Text »  |  PDF »

Toll-like Receptor 4 Region Glu24-Lys47 Is a Site for MD-2 Binding: IMPORTANCE OF CYS29 AND CYS40.

C. Nishitani, H. Mitsuzawa, H. Sano, T. Shimizu, N. Matsushima, and Y. Kuroki (2006)
J. Biol. Chem. 281, 38322-38329
 |  Abstract »  |  Full Text »  |  PDF »

Cell Activation of Human Macrophages by Lipoteichoic Acid Is Strongly Attenuated by Lipopolysaccharide-binding Protein.

M. Mueller, C. Stamme, C. Draing, T. Hartung, U. Seydel, and A. B. Schromm (2006)
J. Biol. Chem. 281, 31448-31456
 |  Abstract »  |  Full Text »  |  PDF »

Invited review: Mechanisms of endotoxin neutralization by synthetic cationic compounds.

J. Andra, T. Gutsmann, P. Garidel, and K. Brandenburg (2006)
Innate Immunity 12, 261-277
 |  Abstract »  |  PDF »

MHC Class II Molecules Control Murine B Cell Responsiveness to Lipopolysaccharide Stimulation.

J. Rodo, L. A. Goncalves, J. Demengeot, A. Coutinho, and C. Penha-Goncalves (2006)
J. Immunol. 177, 4620-4626
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.

M. Lehnert, T. Uehara, B. U. Bradford, H. Lind, Z. Zhong, D. A. Brenner, I. Marzi, and J. J. Lemasters (2006)
Am J Physiol Gastrointest Liver Physiol 291, G456-G463
 |  Abstract »  |  Full Text »  |  PDF »

Invited review: Roles for accessory molecules in microbial recognition by Toll-like receptors.

K. Miyake (2006)
Innate Immunity 12, 195-204
 |  Abstract »  |  PDF »

The novel {beta}-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo.

D. Motzkus, S. Schulz-Maronde, A. Heitland, A. Schulz, W.-G. Forssmann, M. Jubner, and E. Maronde (2006)
FASEB J 20, 1701-1702
 |  Abstract »  |  Full Text »  |  PDF »

All-trans retinoic acid-induced expression of bactericidal/permeability-increasing protein (BPI) in human myeloid cells correlates to binding of C/EBP{beta} and C/EBP{epsilon} to the BPI promoter.

A. Lennartsson, K. Vidovic, M. B. Pass, J. B. Cowland, and U. Gullberg (2006)
J. Leukoc. Biol. 80, 196-203
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome.

A.-l. Stahl, M. Svensson, M. Morgelin, C. Svanborg, P. I. Tarr, J. C. Mooney, S. L. Watkins, R. Johnson, and D. Karpman (2006)
Blood 108, 167-176
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering.

M. Kobayashi, S.-i. Saitoh, N. Tanimura, K. Takahashi, K. Kawasaki, M. Nishijima, Y. Fujimoto, K. Fukase, S. Akashi-Takamura, and K. Miyake (2006)
J. Immunol. 176, 6211-6218
 |  Abstract »  |  Full Text »  |  PDF »

Agonistic Antibody to TLR4/MD-2 Protects Mice from Acute Lethal Hepatitis Induced by TNF-{alpha}.

S. Akashi-Takamura, T. Furuta, K. Takahashi, N. Tanimura, Y. Kusumoto, T. Kobayashi, S.-i. Saitoh, Y. Adachi, T. Doi, and K. Miyake (2006)
J. Immunol. 176, 4244-4251
 |  Abstract »  |  Full Text »  |  PDF »

Localization of the Lipopolysaccharide-binding Protein in Phospholipid Membranes by Atomic Force Microscopy.

S. Roes, F. Mumm, U. Seydel, and T. Gutsmann (2006)
J. Biol. Chem. 281, 2757-2763
 |  Abstract »  |  Full Text »  |  PDF »

Endotoxin (Lipopolysaccharide) Neutralization by Innate Immunity Host-Defense Peptides: PEPTIDE PROPERTIES AND PLAUSIBLE MODES OF ACTION.

Y. Rosenfeld, N. Papo, and Y. Shai (2006)
J. Biol. Chem. 281, 1636-1643
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Mechanisms Regulating Endothelial Permeability.

D. Mehta and A. B. Malik (2006)
Physiol Rev 86, 279-367
 |  Abstract »  |  Full Text »  |  PDF »

Innate Immunity in the Lungs.

T. R. Martin and C. W. Frevert (2005)
Proceedings of the ATS 2, 403-411
 |  Abstract »  |  Full Text »  |  PDF »

The importance of the gastrointestinal system in the pathogenesis of heart failure.

A. Krack, R. Sharma, H. R. Figulla, and S. D. Anker (2005)
Eur. Heart J. 26, 2368-2374
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Lipopolysaccharide-Binding Functions of CD14 and MD-2.

J. Koraha, N. Tsuneyoshi, M. Kimoto, J.-F. Gauchat, H. Nakatake, and K. Fukudome (2005)
Clin. Vaccine Immunol. 12, 1292-1297
 |  Abstract »  |  Full Text »  |  PDF »

Endotoxin: physical requirements for cell activation.

M. Mueller, B. Lindner, R. Dedrick, A.B. Schromm, and U. Seydel (2005)
Innate Immunity 11, 299-303
 |  Abstract »  |  PDF »

Potentiation of Lipopolysaccharide-Induced Chemokine and Adhesion Molecule Expression in Corneal Fibroblasts by Soluble CD14 or LPS-Binding Protein.

K. Fukuda, N. Kumagai, K. Yamamoto, Y. Fujitsu, N. Chikamoto, and T. Nishida (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3095-3101
 |  Abstract »  |  Full Text »  |  PDF »

Non-LPS targets and actions of LPS binding protein (LBP).

N. W.J. Schroder and R. R. Schumann (2005)
Innate Immunity 11, 237-242
 |  Abstract »  |  PDF »

Lipopolysaccharide Heterogeneity: Innate Host Responses to Bacterial Modification of Lipid A Structure.

D.R. Dixon and R.P. Darveau (2005)
Journal of Dental Research 84, 584-595
 |  Abstract »  |  Full Text »  |  PDF »

LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK.

H. Eutamene, V. Theodorou, F. Schmidlin, V. Tondereau, R. Garcia-Villar, C. Salvador-Cartier, M. Chovet, C. Bertrand, and L. Bueno (2005)
Eur. Respir. J. 25, 789-796
 |  Abstract »  |  Full Text »  |  PDF »

LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils.

X. Zhou, X.-P. Gao, J. Fan, Q. Liu, K. N. Anwar, R. S. Frey, and A. B. Malik (2005)
Am J Physiol Lung Cell Mol Physiol 288, L655-L662
 |  Abstract »  |  Full Text »  |  PDF »

Crystal Structure of CD14 and Its Implications for Lipopolysaccharide Signaling.

J.-I. Kim, C. J. Lee, M. S. Jin, C.-H. Lee, S.-G. Paik, H. Lee, and J.-O. Lee (2005)
J. Biol. Chem. 280, 11347-11351
 |  Abstract »  |  Full Text »  |  PDF »

Thematic review series: The Immune System and Atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis.

P. Tobias and L. K. Curtiss (2005)
J. Lipid Res. 46, 404-411
 |  Abstract »  |  Full Text »  |  PDF »

Heparin Binds to Lipopolysaccharide (LPS)-Binding Protein, Facilitates the Transfer of LPS to CD14, and Enhances LPS-Induced Activation of Peripheral Blood Monocytes.

M. Heinzelmann and H. Bosshart (2005)
J. Immunol. 174, 2280-2287
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipids Inhibit Lipopolysaccharide (LPS)-Induced Cell Activation: A Role for LPS-Binding Protein.

M. Mueller, K. Brandenburg, R. Dedrick, A. B. Schromm, and U. Seydel (2005)
J. Immunol. 174, 1091-1096
 |  Abstract »  |  Full Text »  |  PDF »

Acute-Phase Concentrations of Lipopolysaccharide (LPS)-Binding Protein Inhibit Innate Immune Cell Activation by Different LPS Chemotypes via Different Mechanisms.

L. Hamann, C. Alexander, C. Stamme, U. Zahringer, and R. R. Schumann (2005)
Infect. Immun. 73, 193-200
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-Induced Expression of Intercellular Adhesion Molecule-1 and Chemokines in Cultured Human Corneal Fibroblasts.

N. Kumagai, K. Fukuda, Y. Fujitsu, Y. Lu, N. Chikamoto, and T. Nishida (2005)
Invest. Ophthalmol. Vis. Sci. 46, 114-120
 |  Abstract »  |  Full Text »  |  PDF »

Macrophage Migration Inhibitory Factor Is Released from Pituitary Folliculo-Stellate-Like Cells by Endotoxin and Dexamethasone and Attenuates the Steroid-Induced Inhibition of Interleukin 6 Release.

T. Tierney, R. Patel, C. A. S. Stead, L. Leng, R. Bucala, and J. C. Buckingham (2005)
Endocrinology 146, 35-43
 |  Abstract »  |  Full Text »  |  PDF »

The Amino-terminal Region of Toll-like Receptor 4 Is Essential for Binding to MD-2 and Receptor Translocation to the Cell Surface.

T. Fujimoto, S. Yamazaki, A. Eto-Kimura, K. Takeshige, and T. Muta (2004)
J. Biol. Chem. 279, 47431-47437
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of a Novel Lymphocyte Population, Positive for an Intracellular CD14-Like Antigen, in Patients Positive for Human Immunodeficiency Virus Type 1.

D. Turner, M. Hoffman, I. Yust, M. Fried, M. Bleiberg, and B. Tartakovsky (2004)
Clin. Vaccine Immunol. 11, 1040-1044
 |  Abstract »  |  Full Text »  |  PDF »

Role of Protein Tyrosine Kinase p53/56lyn in Diminished Lipopolysaccharide Priming of Formylmethionylleucyl- phenylalanine-Induced Superoxide Production in Human Newborn Neutrophils.

S. R. Yan, D. M. Byers, and R. Bortolussi (2004)
Infect. Immun. 72, 6455-6462
 |  Abstract »  |  Full Text »  |  PDF »

LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.

J. Branger, S. Florquin, S. Knapp, J. C. Leemans, J. M. Pater, P. Speelman, D. T. Golenbock, and T. van der Poll (2004)
Int. Immunol. 16, 1605-1611
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide binding protein in preterm infants.

D Behrendt, J Dembinski, A Heep, and P Bartmann (2004)
Arch. Dis. Child. Fetal Neonatal Ed. 89, F551-F554
 |  Abstract »  |  Full Text »  |  PDF »

A Lentiviral cDNA Library Employing Lambda Recombination Used To Clone an Inhibitor of Human Immunodeficiency Virus Type 1-Induced Cell Death.

Y. Kawano, T. Yoshida, K. Hieda, J. Aoki, H. Miyoshi, and Y. Koyanagi (2004)
J. Virol. 78, 11352-11359
 |  Abstract »  |  Full Text »  |  PDF »

Porphyromonas gingivalis Lipopolysaccharide Contains Multiple Lipid A Species That Functionally Interact with Both Toll-Like Receptors 2 and 4.

R. P. Darveau, T.-T. T. Pham, K. Lemley, R. A. Reife, B. W. Bainbridge, S. R. Coats, W. N. Howald, S. S. Way, and A. M. Hajjar (2004)
Infect. Immun. 72, 5041-5051
 |  Abstract »  |  Full Text »  |  PDF »

CHRONIC ALCOHOLISM CAUSES DELETERIOUS CONDITIONING OF INNATE IMMUNITY.

J. Frank, K. Witte, W. Schrodl, and C. Schutt (2004)
Alcohol Alcohol. 39, 386-392
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses.

N. W. J. Schroder, H. Heine, C. Alexander, M. Manukyan, J. Eckert, L. Hamann, U. B. Gobel, and R. R. Schumann (2004)
J. Immunol. 173, 2683-2691
 |  Abstract »  |  Full Text »  |  PDF »

Uropathogenic Escherichia coli Triggers Oxygen-Dependent Apoptosis in Human Neutrophils through the Cooperative Effect of Type 1 Fimbriae and Lipopolysaccharide.

R. Blomgran, L. Zheng, and O. Stendahl (2004)
Infect. Immun. 72, 4570-4578
 |  Abstract »  |  Full Text »  |  PDF »

Innate Sensing of Viruses by Toll-Like Receptors.

K. W. Boehme and T. Compton (2004)
J. Virol. 78, 7867-7873
 |  Full Text »  |  PDF »

Role for CD14, TLR2, and TLR4 in bacterial product-induced anorexia.

C. von Meyenburg, B. H. Hrupka, D. Arsenijevic, G. J. Schwartz, R. Landmann, and W. Langhans (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R298-R305
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Bovine Innate Immune Response to Intramammary Infection with Klebsiella pneumoniae.

D. D. Bannerman, M. J. Paape, W. R. Hare, and J. C. Hope (2004)
J Dairy Sci 87, 2420-2432
 |  Abstract »  |  Full Text »  |  PDF »

Early-Phase Alcoholic Liver Disease: An Update on Animal Models, Pathology, and Pathogenesis.

S. K. Ramaiah, C. Rivera, and G. E. Arteel (2004)
International Journal of Toxicology 23, 217-231
 |  Abstract »  |  Full Text »  |  PDF »

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.

S.-i. Saitoh, S. Akashi, T. Yamada, N. Tanimura, M. Kobayashi, K. Konno, F. Matsumoto, K. Fukase, S. Kusumoto, Y. Nagai, et al. (2004)
Int. Immunol. 16, 961-969
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide induces expression of fibronectin {alpha}5{beta}1-integrin receptors in human monocytic cells in a protein kinase C-dependent fashion.

J. Roman, J. D. Ritzenthaler, B. Boles, M. Lois, and S. Roser-Page (2004)
Am J Physiol Lung Cell Mol Physiol 287, L239-L249
 |  Abstract »  |  Full Text »  |  PDF »

Functional Polymorphisms in the Promoter Region of Macrophage Migration Inhibitory Factor and Atopy.

N. Hizawa, E. Yamaguchi, D. Takahashi, J. Nishihira, and M. Nishimura (2004)
Am. J. Respir. Crit. Care Med. 169, 1014-1018
 |  Abstract »  |  Full Text »  |  PDF »

Role of MyD88 in Diminished Tumor Necrosis Factor Alpha Production by Newborn Mononuclear Cells in Response to Lipopolysaccharide.

S. R. Yan, G. Qing, D. M. Byers, A. W. Stadnyk, W. Al-Hertani, and R. Bortolussi (2004)
Infect. Immun. 72, 1223-1229
 |  Abstract »  |  Full Text »  |  PDF »

The dual role of LBP and CD14 in response to Gram-negative bacteria or Gram-negative compounds.

D. Heumann, R. Lauener, and B. Ryffel (2003)
Innate Immunity 9, 381-384
 |  Abstract »  |  PDF »

Artificially controlled aggregation of proteins and targeting in hematopoietic cells.

H. Rosen, Y. Gao, E. Johnsson, and I. Olsson (2003)
J. Leukoc. Biol. 74, 800-809
 |  Abstract »  |  Full Text »  |  PDF »

Molecular basis of endothelial dysfunction in sepsis.

K. Peters, R. E. Unger, J. Brunner, and C.J. Kirkpatrick (2003)
Cardiovasc Res 60, 49-57
 |  Abstract »  |  Full Text »  |  PDF »

Pneumococcal Lipoteichoic Acid (LTA) Is Not as Potent as Staphylococcal LTA in Stimulating Toll-Like Receptor 2.

S. H. Han, J. H. Kim, M. Martin, S. M. Michalek, and M. H. Nahm (2003)
Infect. Immun. 71, 5541-5548
 |  Abstract »  |  Full Text »  |  PDF »

Endotoxemia and hepatic injury in a rodent model of hindlimb unloading.

C. A. Rivera, M. H. Tcharmtchi, L. Mendoza, and C. W. Smith (2003)
J Appl Physiol 95, 1656-1663
 |  Abstract »  |  Full Text »  |  PDF »

Increased Levels of LPS-Binding Protein in Bovine Blood and Milk Following Bacterial Lipopolysaccharide Challenge.

D. D. Bannerman, M. J. Paape, W. R. Hare, and E. J. Sohn (2003)
J Dairy Sci 86, 3128-3137
 |  Abstract »  |  Full Text »  |  PDF »

Lipomannans, But Not Lipoarabinomannans, Purified from Mycobacterium chelonae and Mycobacterium kansasii Induce TNF-{alpha} and IL-8 Secretion by a CD14-Toll-Like Receptor 2-Dependent Mechanism.

C. Vignal, Y. Guerardel, L. Kremer, M. Masson, D. Legrand, J. Mazurier, and E. Elass (2003)
J. Immunol. 171, 2014-2023
 |  Abstract »  |  Full Text »  |  PDF »

The Proteasome as a Lipopolysaccharide-Binding Protein in Macrophages: Differential Effects of Proteasome Inhibition on Lipopolysaccharide-Induced Signaling Events.

N. Qureshi, P.-Y. Perera, J. Shen, G. Zhang, A. Lenschat, G. Splitter, D. C. Morrison, and S. N. Vogel (2003)
J. Immunol. 171, 1515-1525
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide (LPS)-binding Protein Inhibits Responses to Cell-bound LPS.

P. A. Thompson, P. S. Tobias, S. Viriyakosol, T. N. Kirkland, and R. L. Kitchens (2003)
J. Biol. Chem. 278, 28367-28371
 |  Abstract »  |  Full Text »  |  PDF »

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock.

E. S. Van Amersfoort, T. J. C. Van Berkel, and J. Kuiper (2003)
Clin. Microbiol. Rev. 16, 379-414
 |  Abstract »  |  Full Text »  |  PDF »

Safety and Pharmacokinetics of an Endotoxin-Binding Phospholipid Emulsion.

B. R Gordon, T. S Parker, D. M Levine, S. D Saal, L. C. Hudgins, B.-J. Sloan, C. Chu, K. H Stenzel, and A. L Rubin (2003)
Ann. Pharmacother. 37, 943-950
 |  Abstract »  |  Full Text »  |  PDF »

Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex.

A. Bjerre, B. Brusletto, R. Ovstebo, G. B. Joo, P. Kierulf, and P. Brandtzaeg (2003)
Innate Immunity 9, 155-163
 |  Abstract »  |  PDF »

The role of membrane-bound LBP, endotoxin aggregates, and the MaxiK channel in LPS-induced cell activation.

M. Muller, O. Scheel, B. Lindner, T. Gutsmann, and U. Seydel (2003)
Innate Immunity 9, 181-186
 |  Abstract »  |  PDF »

Elevation of Basal Intracellular Calcium as a Central Element in the Activation of Brain Macrophages (Microglia): Suppression of Receptor-Evoked Calcium Signaling and Control of Release Function.

A. Hoffmann, O. Kann, C. Ohlemeyer, U.-K. Hanisch, and H. Kettenmann (2003)
J. Neurosci. 23, 4410-4419
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Single Nucleotide Polymorphism in the Lipopolysaccharide Binding Protein and Its Association with Sepsis.

R. C. Barber and G. E. O'Keefe (2003)
Am. J. Respir. Crit. Care Med. 167, 1316-1320
 |  Abstract »  |  Full Text »  |  PDF »

Lipoteichoic Acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved.

N. W. J. Schroder, S. Morath, C. Alexander, L. Hamann, T. Hartung, U. Zahringer, U. B. Gobel, J. R. Weber, and R. R. Schumann (2003)
J. Biol. Chem. 278, 15587-15594
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors.

K. C. Malcolm and G. S. Worthen (2003)
J. Biol. Chem. 278, 15693-15701
 |  Abstract »  |  Full Text »  |  PDF »

Review: Towards antibacterial strategies: studies on the mechanisms of interaction between antibacterial peptides and model membranes.

A. Wiese, T. Gutsmann, and U. Seydel (2003)
Innate Immunity 9, 67-84
 |  Abstract »  |  PDF »

Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells.

K. L. Lohmann, M. Vandenplas, M. H. Barton, and J. N. Moore (2003)
Innate Immunity 9, 33-37
 |  Abstract »  |  PDF »

To Advertise   |   Find Products