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Science 14 September 1990:
Vol. 249. no. 4974, pp. 1298 - 1300
DOI: 10.1126/science.2399464
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Articles

Science, Vol 249, Issue 4974, 1298-1300
Copyright © 1990 by American Association for the Advancement of Science

articles

NKR-P1, a signal transduction molecule on natural killer cells

R Giorda, WA Rudert, C Vavassori, WH Chambers, JC Hiserodt, and M Trucco

Pittsburgh Cancer Institute, PA.

Natural killer (NK) cells are a subpopulation of large granular lymphocytes characterized by densely staining azurophilic granules. NK cells are able to recognize and lyse various virally infected or neoplastic target cells without previous sensitization or major histocompatibility complex restriction. A 60-kD disulfide-linked dimer, highly expressed on NK cells, was found capable of mediating transmembrane signaling. The gene encoding this signal transduction molecule was cloned and its nucleotide sequence determined. The encoded protein showed significant homology with a number of lectin-related membrane proteins that share receptor characteristics. This protein may function as a receptor able to selectively trigger NK cell activity.


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