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Science 14 September 1990:
Vol. 249. no. 4974, pp. 1266 - 1272
DOI: 10.1126/science.2119054
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Articles

Science, Vol 249, Issue 4974, 1266-1272
Copyright © 1990 by American Association for the Advancement of Science

articles

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element

MI Diamond, JN Miner, SK Yoshinaga, and KR Yamamoto

Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.

The mechanism by which a single factor evokes opposite regulatory effects from a specific DNA sequence is not well understood. In this study, a 25-base pair element that resides upstream of the mouse proliferin gene was examined; it conferred on linked promoters either positive or negative glucocorticoid regulation, depending upon physiological context. This sequence, denoted a "composite" glucocorticoid response element (GRE), was bound selectively in vitro both by the glucocorticoid receptor and by c-Jun and c-Fos, components of the phorbol ester-activated AP-1 transcription factor. Indeed, c-Jun and c-Fos served as selectors of hormone responsiveness: the composite GRE was inactive in the absence of c-Jun, whereas it conferred a positive glucocorticoid effect in the presence of c-Jun, and a negative glucocorticoid effect in the presence of c-Jun and relatively high levels of c-Fos. The receptor also interacted selectively with c-Jun in vitro. A general model for composite GRE action is proposed that invokes both DNA binding and protein-protein interactions by receptor and nonreceptor factors.


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P. M. Yen (2001)
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J. Neurosci. 20, 3843-3852
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J. Immunol. 164, 2479-2486
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X.-M. Ma and G. Aguilera (1999)
Endocrinology 140, 5642-5650
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K. Kageyama, M. J. Bradbury, L. Zhao, A. L. Blount, and W. W. Vale (1999)
Endocrinology 140, 5651-5658
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Independent Promoters Regulate the Expression of Two Amino Terminally Distinct Forms of Latent Transforming Growth Factor-beta Binding Protein-1 (LTBP-1) in a Cell Type-specific Manner.
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Mol. Cell. Biol. 19, 5036-5049
   Abstract »    Full Text »    PDF »
Identification of a Retinoic Acid-Inducible Element in the Murine PTH/PTHrP (Parathyroid Hormone/Parathyroid Hormone-Related Peptide) Receptor Gene.
M. Karperien, H. Farih-Sips, J. A.A. Hendriks, B. Lanske, S. E. Papapoulos, A.-B. Abou-Samra, C. W.G.M. Löwik, and L. H.K. Defize (1999)
Mol. Endocrinol. 13, 1183-1196
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Receptor Interacting Protein RIP140 Inhibits Both Positive and Negative Gene Regulation by Glucocorticoids.
N. Subramaniam, E. Treuter, and S. Okret (1999)
J. Biol. Chem. 274, 18121-18127
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A Two-Hit Mechanism for Vitamin D3-Mediated Transcriptional Repression of the Granulocyte-Macrophage Colony-Stimulating Factor Gene: Vitamin D Receptor Competes for DNA Binding with NFAT1 and Stabilizes c-Jun.
T. L. Towers, T. P. Staeva, and L. P. Freedman (1999)
Mol. Cell. Biol. 19, 4191-4199
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The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region.
G. Perini, E. Oetjen, and M. R. Green (1999)
J. Biol. Chem. 274, 13970-13977
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Cyclic Adenosine-3',5'-Monophosphate-Mediated Activation of a Glutamine Synthetase Composite Glucocorticoid Response Element.
J. Richardson, C. Vinson, and J. Bodwell (1999)
Mol. Endocrinol. 13, 546-554
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Turning a Negative into a Positive: Vitamin D Receptor Interactions with the Avian Parathyroid Hormone Response Element.
N. J. Koszewski, S. Ashok, and J. Russell (1999)
Mol. Endocrinol. 13, 455-465
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An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors.
H. Hong, B. D. Darimont, H. Ma, L. Yang, K. R. Yamamoto, and M. R. Stallcup (1999)
J. Biol. Chem. 274, 3496-3502
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Ligand-Activated Retinoic Acid Receptor Inhibits AP-1 Transactivation by Disrupting c-Jun/c-Fos Dimerization.
X.-F. Zhou, X.-Q. Shen, and L. Shemshedini (1999)
Mol. Endocrinol. 13, 276-285
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Dexamethasone Stimulates Human A1 Adenosine Receptor (A1AR) Gene Expression through Multiple Regulatory Sites in Promoter B.
H. Ren and G. L. Stiles (1999)
Mol. Pharmacol. 55, 309-316
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The Glucocorticoid Receptor Is Tethered to DNA-bound Oct-1 at the Mouse Gonadotropin-releasing Hormone Distal Negative Glucocorticoid Response Element.
U. R. Chandran, B. S. Warren, C. T. Baumann, G. L. Hager, and D. B. DeFranco (1999)
J. Biol. Chem. 274, 2372-2378
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AP-1 and Vitamin D Receptor (VDR) Signaling Pathways Converge at the Rat Osteocalcin VDR Element: Requirement for the Internal Activating Protein-1 Site for Vitamin D-Mediated Trans-Activation.
F. Aslam, L. McCabe, B. Frenkel, A. J. van Wijnen, G. S. Stein, J. B. Lian, and J. L. Stein (1999)
Endocrinology 140, 63-70
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Dysfunctional glucocorticoid receptor with a single point mutation ablates the CCAAT/enhancer binding protein-dependent growth suppression response in a steroid-resistant rat hepatoma cell variant.
R. A. Ramos, W. J. Meilandt, E. C. Wang, and G. L. Firestone (1999)
FASEB J 13, 169-180
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Up- and Down-Regulation by Glucocorticoids of the Constitutive Expression of the Mast Cell Growth Factor Stem Cell Factor by Human Lung Fibroblasts in Culture.
O. Kassel, F. Schmidlin, C. Duvernelle, F. de Blay, and N. Frossard (1998)
Mol. Pharmacol. 54, 1073-1079
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Glucocorticoid Receptor Transcriptional Activity Determined by Spacing of Receptor and Nonreceptor DNA Sites.
D. Pearce, W. Matsui, J. N. Miner, and K. R. Yamamoto (1998)
J. Biol. Chem. 273, 30081-30085
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AF-2-Dependent Potentiation of CCAAT Enhancer Binding Protein {beta}-Mediated Transcriptional Activation by Glucocorticoid Receptor.
M. Boruk, J. G. A. Savory, and R. J. G. Haché (1998)
Mol. Endocrinol. 12, 1749-1763
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Characterization of Functional Domains of an Embryonic Stem Cell Coactivator UTF1 Which Are Conserved and Essential for Potentiation of ATF-2 Activity.
A. Fukushima, A. Okuda, M. Nishimoto, N. Seki, T.-a. Hori, and M. Muramatsu (1998)
J. Biol. Chem. 273, 25840-25849
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