Science 31 August 1990: Vol. 249. no. 4972, pp. 1049 - 1051 DOI: 10.1126/science.2144364

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Articles

TAFII70 Isoform-Specific Growth Suppression Correlates With Its Ability to Complex With the GADD45a Protein.

W. Wang, R. Nahta, G. Huper, and J. R. Marks (2004)
Mol. Cancer Res. 2, 442-452
 |  Abstract »  |  Full Text »  |  PDF »

Prostate-Specific Expression of p53R172L Differentially Regulates p21, Bax, and mdm2 to Inhibit Prostate Cancer Progression and Prolong Survival.

I. Hernandez, L. A. Maddison, Y. Wei, F. DeMayo, T. Petras, B. Li, J. R. Gingrich, J. M. Rosen, and N. M. Greenberg (2003)
Mol. Cancer Res. 1, 1036-1047
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Models to Study the Interaction of Risk Factors for Human Liver Cancer.

S. Sell (2003)
Cancer Res. 63, 7553-7562
 |  Abstract »  |  Full Text »  |  PDF »

The Proteasome Inhibitor Bortezomib Stabilizes a Novel Active Form of p53 in Human LNCaP-Pro5 Prostate Cancer Cells.

S. A. Williams and D. J. McConkey (2003)
Cancer Res. 63, 7338-7344
 |  Abstract »  |  Full Text »  |  PDF »

p53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.

I. H. Chowdhury, M. Radonovich, R. Mahieux, C. Pise-Masison, S. Muralidhar, and J. N. Brady (2003)
J. Gen. Virol. 84, 897-906
 |  Abstract »  |  Full Text »  |  PDF »

A Novel p53 Transcriptional Repressor Element (p53TRE) and the Asymmetrical Contribution of Two p53 Binding Sites Modulate the Response of the Placental Transforming Growth Factor-beta Promoter to p53.

J. Wong, P.-X. Li, and H. J. Klamut (2002)
J. Biol. Chem. 277, 26699-26707
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Relationships of TP53 Codon 72 and HRAS1 Polymorphisms with Lung Cancer Risk in an Ethnically Diverse Population.

L. M. Pierce, L. Sivaraman, W. Chang, A. Lum, T. Donlon, A. Seifried, L. R. Wilkens, A. F. Lau, and L. Le Marchand (2000)
Cancer Epidemiol. Biomarkers Prev. 9, 1199-1204
 |  Abstract »  |  Full Text »

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays.

R. Zhao, K. Gish, M. Murphy, Y. Yin, D. Notterman, W. H. Hoffman, E. Tom, D. H. Mack, and A. J. Levine (2000)
Genes & Dev. 14, 981-993
 |  Abstract »  |  Full Text »

The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and Apoptosis.

X. Zeng, X. Li, A. Miller, Z. Yuan, W. Yuan, R. P. S. Kwok, R. Goodman, and H. Lu (2000)
Mol. Cell. Biol. 20, 1299-1310
 |  Abstract »  |  Full Text »

Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis.

D. Munsch, R. Watanabe-Fukunaga, J.-C. Bourdon, S. Nagata, E. May, E. Yonish-Rouach, and P. Reisdorf (2000)
J. Biol. Chem. 275, 3867-3872
 |  Abstract »  |  Full Text »  |  PDF »

p53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines.

O. N. Aurelio, X.-T. Kong, S. Gupta, and E. J. Stanbridge (2000)
Mol. Cell. Biol. 20, 770-778
 |  Abstract »  |  Full Text »

CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines.

G. Teoh, Y.-T. Tai, M. Urashima, S. Shirahama, M. Matsuzaki, D. Chauhan, S. P. Treon, N. Raje, T. Hideshima, Y. Shima, et al. (2000)
Blood 95, 1039-1046
 |  Abstract »  |  Full Text »  |  PDF »

Identification and classification of p53-regulated genes.

J. Yu, L. Zhang, P. M. Hwang, C. Rago, K. W. Kinzler, and B. Vogelstein (1999)
PNAS 96, 14517-14522
 |  Abstract »  |  Full Text »  |  PDF »

One Mechanism for Cell Type-specific Regulation of the bax Promoter by the Tumor Suppressor p53 Is Dictated by the p53 Response Element.

E. C. Thornborrow and J. J. Manfredi (1999)
J. Biol. Chem. 274, 33747-33756
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-mediated Transfer of p33ING1 with p53 Drastically Augments Apoptosis in Gliomas.

N. Shinoura, Y. Muramatsu, M. Nishimura, Y. Yoshida, A. Saito, T. Yokoyama, T. Furukawa, A. Horii, M. Hashimoto, A. Asai, et al. (1999)
Cancer Res. 59, 5521-5528
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Evolution of the Thermosensitive PAb1620 Epitope of Human p53 by DNA Shuffling.

D. P. Xirodimas and D. P. Lane (1999)
J. Biol. Chem. 274, 28042-28049
 |  Abstract »  |  Full Text »  |  PDF »

Physical Interaction and Functional Antagonism between the RNA Polymerase II Elongation Factor ELL and p53.

N. Shinobu, T. Maeda, T. Aso, T. Ito, T. Kondo, K. Koike, and M. Hatakeyama (1999)
J. Biol. Chem. 274, 17003-17010
 |  Abstract »  |  Full Text »  |  PDF »

Murine Double Minute (MDM2) Blocks p53-coactivator Interaction, a New Mechanism for Inhibition of p53-dependent Gene Expression.

R. Wadgaonkar and T. Collins (1999)
J. Biol. Chem. 274, 13760-13767
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of hTAFII32-binding Implicated in the Transcriptional Repression by Central Regions of Mutant p53 Proteins.

S.-F. Tung, J.-Y. Chuang, C.-T. Lin, M.-Y. Lai, C.-W. Wu, and Y.-S. Lin (1999)
J. Biol. Chem. 274, 7748-7755
 |  Abstract »  |  Full Text »  |  PDF »

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage.

L. Liu, D. M. Scolnick, R. C. Trievel, H. B. Zhang, R. Marmorstein, T. D. Halazonetis, and S. L. Berger (1999)
Mol. Cell. Biol. 19, 1202-1209
 |  Abstract »  |  Full Text »  |  PDF »

p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells.

C. J. Di Como, C. Gaiddon, and C. Prives (1999)
Mol. Cell. Biol. 19, 1438-1449
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2.

K. Iwabuchi, B. Li, H. F. Massa, B. J. Trask, T. Date, and S. Fields (1998)
J. Biol. Chem. 273, 26061-26068
 |  Abstract »  |  Full Text »  |  PDF »

Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53.

X. Zeng, A. J. Levine, and H. Lu (1998)
PNAS 95, 6681-6686
 |  Abstract »  |  Full Text »  |  PDF »

Repression of p53-mediated transcription by MDM2: a dual mechanism.

C. J. Thut, J. A. Goodrich, and R. Tjian (1997)
Genes & Dev. 11, 1974-1986
 |  Abstract »  |  Full Text »  |  PDF »

Co-localization of Endogenous and Exogenous p53 Proteins in Nasopharyngeal Carcinoma Cells.

J.-K. Hwang and C.-T. Lin (1997)
J. Histochem. Cytochem. 45, 991-1004
 |  Abstract »  |  Full Text »

Inhibition of Protein Phosphatase Activity Induces p53-dependent Apoptosis in the Absence of p53 Transactivation.

Y. Yan, J. W. Shay, W. E. Wright, and M. C. Mumby (1997)
J. Biol. Chem. 272, 15220-15226
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a novel p53 functional domain that is necessary for efficient growth suppression.

K. K. Walker and A. J. Levine (1996)
PNAS 93, 15335-15340
 |  Abstract »  |  Full Text »  |  PDF »

p53 and Breast Cancer.

P. Robbins (1996)
International Journal of Surgical Pathology 4, 93-110
 |  Abstract »  |  PDF »

c-Krox Binds to Several Sites in the Promoter of Both Mouse Type I Collagen Genes. STRUCTURE/FUNCTION STUDY AND DEVELOPMENTAL EXPRESSION ANALYSIS.

P. Galera, R.-W. Park, P. Ducy, M.-G. Mattei, and G. Karsenty (1996)
J. Biol. Chem. 271, 21331-21339
 |  Abstract »  |  Full Text »  |  PDF »

Allosteric Regulation of the Thermostability and DNA Binding Activity of Human p53 by Specific Interacting Proteins.

S. Hansen, T. R. Hupp, and D. P. Lane (1996)
J. Biol. Chem. 271, 3917-3924
 |  Abstract »  |  Full Text »  |  PDF »

Transactivation Ability of p53 Transcriptional Activation Domain Is Directly Related to the Binding Affinity to TATA-binding Protein.

J. Chang, D.-H. Kim, S. W. Lee, K. Y. Choi, and Y. C. Sung (1995)
J. Biol. Chem. 270, 25014-25019
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis of Rat Vascular Smooth Muscle Cells Is Regulated by p53-Dependent and -Independent Pathways.

M. R. Bennett, G. I. Evan, and S. M. Schwartz (1995)
Circ. Res. 77, 266-273
 |  Abstract »  |  Full Text »

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.

P. Jeffrey, S Gorina, and N. Pavletich (1995)
Science 267, 1498-1502
 |  Abstract »  |  PDF »

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60.

C. Thut, J. Chen, R Klemm, and R Tjian (1995)
Science 267, 100-104
 |  Abstract »  |  PDF »

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein..

J Lin, J Chen, B Elenbaas, and A J Levine (1994)
Genes & Dev. 8, 1235-1246
 |  Abstract »  |  PDF »

Overexpression of p53 Tumor Suppressor Protein in Porokeratosis.

J. W. Magee, T. H. McCalmont, and P. E. LeBoit (1994)
Arch Dermatol 130, 187-190
 |  Abstract »  |  PDF »

Abnormalities of p53 Protein Expression in Cutaneous Disorders.

N. S. McNutt, C. Saenz-Santamaria, M. Volkenandt, C. R. Shea, and A. P. Albino (1994)
Arch Dermatol 130, 225-232
 |  Abstract »  |  PDF »

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases.

T.R. Hupp and D.P. Lane (1994)
Cold Spring Harb Symp Quant Biol 59, 195-206
 |  Abstract »  |  PDF »

Functions of the p53 Protein in Growth Regulation and Tumor Suppression.

J. Lin, X. Wu, J. Chen, A. Chang, and A.J. Levine (1994)
Cold Spring Harb Symp Quant Biol 59, 215-223
 |  Abstract »  |  PDF »

Control of p53-dependent Apoptosis by E1B, Bcl-2, and Ha-ras Proteins.

E. White, S.-K. Chiou, L. Rao, P. Sabbatini, and H.-J. Lin (1994)
Cold Spring Harb Symp Quant Biol 59, 395-402
 |  Abstract »  |  PDF »

p53 in Low-grade Gliomas.

H.-K. Ng, M. Phil, K.-W. Lo, D. P. Huang, and W.-S. Poon (1994)
International Journal of Surgical Pathology 1, 163-170
 |  Abstract »  |  PDF »

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots..

N P Pavletich, K A Chambers, and C O Pabo (1993)
Genes & Dev. 7, 2556-2564
 |  Abstract »  |  PDF »

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein..

J Bargonetti, J J Manfredi, X Chen, D R Marshak, and C Prives (1993)
Genes & Dev. 7, 2565-2574
 |  Abstract »  |  PDF »

p53 domains: identification and characterization of two autonomous DNA-binding regions..

Y Wang, M Reed, P Wang, J E Stenger, G Mayr, M E Anderson, J F Schwedes, and P Tegtmeyer (1993)
Genes & Dev. 7, 2575-2586
 |  Abstract »  |  PDF »

The p53-mdm-2 autoregulatory feedback loop..

X Wu, J H Bayle, D Olson, and A J Levine (1993)
Genes & Dev. 7, 1126-1132
 |  Abstract »  |  PDF »

Regulation of the human hsp70 promoter by p53.

S. Agoff, J Hou, D. Linzer, and B Wu (1993)
Science 259, 84-87
 |  Abstract »  |  PDF »

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53..

J Bargonetti, I Reynisdottir, P N Friedman, and C Prives (1992)
Genes & Dev. 6, 1886-1898
 |  Abstract »  |  PDF »

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element..

G P Zambetti, J Bargonetti, K Walker, C Prives, and A J Levine (1992)
Genes & Dev. 6, 1143-1152
 |  Abstract »  |  PDF »

Oncogenic forms of p53 inhibit p53-regulated gene expression.

S. Kern, J. Pietenpol, S Thiagalingam, A Seymour, K. Kinzler, and B Vogelstein (1992)
Science 256, 827-830
 |  Abstract »  |  PDF »

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

K. Chin, K Ueda, I Pastan, and M. Gottesman (1992)
Science 255, 459-462
 |  Abstract »  |  PDF »

Tumor suppressor genes.

R. Weinberg (1991)
Science 254, 1138-1146
 |  Abstract »  |  PDF »

Transcriptional repression mediated by the WT1 Wilms tumor gene product.

S. Madden, D. Cook, J. Morris, A Gashler, V. Sukhatme, and F. Rauscher III (1991)
Science 253, 1550-1553
 |  Abstract »  |  PDF »

Identification of p53 as a sequence-specific DNA-binding protein.

S. Kern, K. Kinzler, A Bruskin, D Jarosz, P Friedman, C Prives, and B Vogelstein (1991)
Science 252, 1708-1711
 |  Abstract »  |  PDF »

Functional Consequences of the Interactions of the p53 Tumor Suppressor Protein and SV40 Large Tumor Antigen.

C. Prives, J. Bargonetti, P.N. Friedman, J.J. Manfredi, and E.H. Wang (1991)
Cold Spring Harb Symp Quant Biol 56, 227-235
 |  Abstract »  |  PDF »

Suppression of DNA Repair by Human T Cell Leukemia Virus Type 1 Tax Is Rescued by a Functional p53 Signaling Pathway.

S.-Y. Kao, F. J. Lemoine, and S. J. Marriott (2000)
J. Biol. Chem. 275, 35926-35931
 |  Abstract »  |  Full Text »  |  PDF »

p53 Amino Acids 339-346 Represent the Minimal p53 Repression Domain.

T.-M. Hong, J. J. W. Chen, K. Peck, P.-C. Yang, and C.-W. Wu (2001)
J. Biol. Chem. 276, 1510-1515
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a p53 Response Element in the Promoter Region of the hMSH2 Gene Required for Expression in A2780 Ovarian Cancer Cells.

C. T. Warnick, B. Dabbas, C. D. Ford, and K. A. Strait (2001)
J. Biol. Chem. 276, 27363-27370
 |  Abstract »  |  Full Text »  |  PDF »

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