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Science 31 August 1990:
Vol. 249. no. 4972, pp. 1030 - 1033
DOI: 10.1126/science.1697696
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Articles

Science, Vol 249, Issue 4972, 1030-1033
Copyright © 1990 by American Association for the Advancement of Science

articles

Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110

AS Freedman, JM Munro, GE Rice, MP Bevilacqua, C Morimoto, BW McIntyre, K Rhynhart, JS Pober, and LM Nadler

Division of Tumor Immunology, Dana-Farber Cancer Institute and Boston, MA.

Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.


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