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Science 31 August 1990:
Vol. 249. no. 4972, pp. 1030 - 1033
DOI: 10.1126/science.1697696
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Articles
Science, Vol 249, Issue 4972, 1030-1033
Copyright © 1990 by American Association for the Advancement of Science
Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110
AS Freedman,
JM Munro,
GE Rice,
MP Bevilacqua,
C Morimoto,
BW McIntyre,
K Rhynhart,
JS Pober,
and
LM Nadler
Division of Tumor Immunology, Dana-Farber Cancer Institute and Boston, MA.
Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.
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