Science 31 August 1990: Vol. 249. no. 4972, pp. 1007 - 1011 DOI: 10.1126/science.2204108

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Articles

Case Study: An Evaluation of the Human Relevance of the Synthetic Pyrethroid Metofluthrin-Induced Liver Tumors in Rats Based on Mode of Action.

T. Yamada, S. Uwagawa, Y. Okuno, S. M. Cohen, and H. Kaneko (2009)
Toxicol. Sci. 108, 59-68
 |  Abstract »  |  Full Text »  |  PDF »

Mouse models for the study of colon carcinogenesis.

D. W. Rosenberg, C. Giardina, and T. Tanaka (2009)
Carcinogenesis 30, 183-196
 |  Abstract »  |  Full Text »  |  PDF »

Cell Competition and Its Possible Relation to Cancer.

N. E. Baker and W. Li (2008)
Cancer Res. 68, 5505-5507
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Tobacco Smoke on Gene Expression and Cellular Pathways in a Cellular Model of Oral Leukoplakia.

Z. H. Gumus, B. Du, A. Kacker, J. O. Boyle, J. M. Bocker, P. Mukherjee, K. Subbaramaiah, A. J. Dannenberg, and H. Weinstein (2008)
Cancer Prevention Research 1, 100-111
 |  Abstract »  |  Full Text »  |  PDF »

Donation Frequency, Iron Loss, and Risk of Cancer Among Blood Donors.

G. Edgren, M. Reilly, H. Hjalgrim, T. N. Tran, K. Rostgaard, J. Adami, K. Titlestad, A. Shanwell, M. Melbye, and O. Nyren (2008)
J Natl Cancer Inst 100, 572-579
 |  Abstract »  |  Full Text »  |  PDF »

Antioxidant biofactor, a processed grain food, inhibits iron nitrilotriacetate-induced renal tumorigenesis, hyperproliferative response, and oxidative damage.

A Mizote, Y Okazaki, M Iqbal, and S Okada (2008)
Human and Experimental Toxicology 27, 207-214
 |  Abstract »  |  PDF »

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis.

S. Y. Nam, J. S. Kim, J. M. Kim, J. Y. Lee, N. Kim, H. C. Jung, and I. S. Song (2008)
Experimental Biology and Medicine 233, 180-191
 |  Abstract »  |  Full Text »  |  PDF »

Prior bleeding enhances the sensitivity of peripheral blood and bone marrow micronucleus tests in rats.

A. Vikram, P. Ramarao, and G. Jena (2007)
Mutagenesis 22, 287-291
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Urethane-Induced Carcinogenicity in Cyp2e1-/- in Comparison to Cyp2e1+/+ Mice.

B. I. Ghanayem (2007)
Toxicol. Sci. 95, 331-339
 |  Abstract »  |  Full Text »  |  PDF »

Oral Contraceptive Use as a Risk Factor for Premenopausal Breast Cancer: A Meta-analysis.

C. Kahlenborn, F. Modugno, D. M. Potter, and W. B. Severs (2006)
Mayo Clin. Proc. 81, 1290-1302
 |  Abstract »  |  Full Text »  |  PDF »

Progesterone metabolites in breast cancer..

J. P Wiebe (2006)
Endocr. Relat. Cancer 13, 717-738
 |  Abstract »  |  Full Text »  |  PDF »

Chemopreventive effect of trans-resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis.

M. Sengottuvelan, P. Viswanathan, and N. Nalini (2006)
Carcinogenesis 27, 1038-1046
 |  Abstract »  |  Full Text »  |  PDF »

Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement.

F.-X. Liang, M. C. Bosland, H. Huang, R. Romih, S. Baptiste, F.-M. Deng, X.-R. Wu, E. Shapiro, and T.-T. Sun (2005)
J. Cell Biol. 171, 835-844
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Urinary Bladder Carcinogenicity of Sodium L-Ascorbate in Human c-Ha-ras Proto-Oncogene Transgenic Rats.

K. Morimura, J. S. Kang, M. Wei, H. Wanibuchi, H. Tsuda, and S. Fukushima (2005)
Toxicol Pathol 33, 766-769
 |  Abstract »  |  Full Text »  |  PDF »

Tobacco Smoke Stimulates the Transcription of Amphiregulin in Human Oral Epithelial Cells: Evidence of a Cyclic AMP-Responsive Element Binding Protein-Dependent Mechanism.

B. Du, N. K. Altorki, L. Kopelovich, K. Subbaramaiah, and A. J. Dannenberg (2005)
Cancer Res. 65, 5982-5988
 |  Abstract »  |  Full Text »  |  PDF »

Levels of Cyclooxygenase-2 Are Increased in the Oral Mucosa of Smokers: Evidence for the Role of Epidermal Growth Factor Receptor and Its Ligands.

D. Moraitis, B. Du, M. S. De Lorenzo, J. O. Boyle, B. B. Weksler, E. G. Cohen, J. F. Carew, N. K. Altorki, L. Kopelovich, K. Subbaramaiah, et al. (2005)
Cancer Res. 65, 664-670
 |  Abstract »  |  Full Text »  |  PDF »

Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention.

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois (2005)
J. Clin. Oncol. 23, 254-266
 |  Abstract »  |  Full Text »  |  PDF »

Differential Display in Rat Livers Treated for 13 Weeks with Phenobarbital Implicates a Role for Metabolic and Oxidative Stress in Nongenotoxic Carcinogenicity.

M. M. Elrick, J. A. Kramer, C. L. Alden, E. A. G. Blomme, R. T. Bunch, M. A. Cabonce, S. W. Curtiss, L. D. Kier, K. L. Kolaja, C. P. Rodi, et al. (2005)
Toxicol Pathol 33, 118-126
 |  Abstract »  |  Full Text »  |  PDF »

Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset.

R. B. Conolly, J. S. Kimbell, D. Janszen, P. M. Schlosser, D. Kalisak, J. Preston, and F. J. Miller (2004)
Toxicol. Sci. 82, 279-296
 |  Abstract »  |  Full Text »  |  PDF »

Serum Levels of Insulin Growth Factor (IGF-I) and IGF-Binding Protein Predict Risk of Second Primary Tumors in Patients with Head and Neck Cancer.

X. Wu, H. Zhao, K.-A. Do, M. M. Johnson, Q. Dong, W. K. Hong, and M. R. Spitz (2004)
Clin. Cancer Res. 10, 3988-3995
 |  Abstract »  |  Full Text »  |  PDF »

An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-{alpha} expression and cell proliferation.

M. Kagawa, T. Sano, N. Ishibashi, M. Hashimoto, M. Okuno, H. Moriwaki, R. Suzuki, H. Kohno, and T. Tanaka (2004)
Carcinogenesis 25, 979-985
 |  Abstract »  |  Full Text »  |  PDF »

Elevated Serum Insulin-Like Growth Factor Binding Protein-2 as a Prognostic Marker in Patients with Ovarian Cancer.

S. Baron-Hay, F. Boyle, A. Ferrier, and C. Scott (2004)
Clin. Cancer Res. 10, 1796-1806
 |  Abstract »  |  Full Text »  |  PDF »

Thresholds for the Effects of 2-Acetylaminofluorene in Rat Liver.

G. M. Williams, M. J. Iatropoulos, and A. M. Jeffrey (2004)
Toxicol Pathol 32, 85-91
 |  Abstract »  |  PDF »

Risk Assessment in the Genomic Era.

S. M. Cohen (2004)
Toxicol Pathol 32, 3-8
 |  Abstract »  |  PDF »

Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment.

R. B. Conolly and W. K. Lutz (2004)
Toxicol. Sci. 77, 151-157
 |  Abstract »  |  Full Text »  |  PDF »

Biologically Motivated Computational Modeling of Formaldehyde Carcinogenicity in the F344 Rat.

R. B. Conolly, J. S. Kimbell, D. Janszen, P. M. Schlosser, D. Kalisak, J. Preston, and F. J. Miller (2003)
Toxicol. Sci. 75, 432-447
 |  Abstract »  |  Full Text »  |  PDF »

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor {alpha}-converting Enzyme and Amphiregulin.

H. Lemjabbar, D. Li, M. Gallup, S. Sidhu, E. Drori, and C. Basbaum (2003)
J. Biol. Chem. 278, 26202-26207
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Toxicity as an Early Event in Urinary Bladder Carcinogenesis Induced by Phenethyl Isothiocyanate, Benzyl Isothiocyanate, and Analogues in F344 Rats.

K. Akagi, M. Sano, K. Ogawa, M. Hirose, H. Goshima, and T. Shirai (2003)
Toxicol Pathol 31, 388-396
 |  Abstract »  |  PDF »

Transcription Profiling Distinguishes Dose-Dependent Effects in the Livers of Rats Treated with Clofibrate.

J. A. Kramer, E. A.G. Blomme, R. T. Bunch, J. C. Davila, C. J. Jackson, P. F. Jones, K. L. Kolaja, and S. W. Curtiss (2003)
Toxicol Pathol 31, 417-431
 |  Abstract »  |  PDF »

Stochastic Simulation of Hepatic Preneoplastic Foci Development for Four Chlorobenzene Congeners in a Medium-Term Bioassay.

Y. C. Ou, R. B. Conolly, R. S. Thomas, D. L. Gustafson, M. E. Long, I. D. Dobrev, L. S. Chubb, Y. Xu, S. A. Lapidot, M. E. Andersen, et al. (2003)
Toxicol. Sci. 73, 301-314
 |  Abstract »  |  Full Text »  |  PDF »

Malgun (Clear) Cell Change in Helicobacter pylori Gastritis Reflects Epithelial Genomic Damage and Repair.

J. Jang, S. Lee, Y. Jung, K. Song, M. Fukumoto, V. E. Gould, and I. Lee (2003)
Am. J. Pathol. 162, 1203-1211
 |  Abstract »  |  Full Text »  |  PDF »

Different Effects of the Liver Mitogens Triiodo-Thyronine and Ciprofibrate on the Development of Rat Hepatocellular Carcinoma.

G. M. Ledda-Columbano, A. Perra, D. Concas, C. Cossu, F. Molotzu, C. Sartori, H. Shinozuka, and A. Columbano (2003)
Toxicol Pathol 31, 113-120
 |  Abstract »  |  PDF »

Dopamine Antagonists and the Development of Breast Cancer.

P. S. Wang, A. M. Walker, M. T. Tsuang, E. J. Orav, R. J. Glynn, R. Levin, and J. Avorn (2002)
Arch Gen Psychiatry 59, 1147-1154
 |  Abstract »  |  Full Text »  |  PDF »

Diet, cancer and aging in DNA mismatch repair deficient mice.

J.-L. Tsao, S. Dudley, B. Kwok, A. E. Nickel, P. W. Laird, K. D. Siegmund, R. M. Liskay, and D. Shibata (2002)
Carcinogenesis 23, 1807-1810
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Pathology of Proliferative Lesions of the Urinary Bladder.

S. M. Cohen (2002)
Toxicol Pathol 30, 663-671
 |  Abstract »  |  PDF »

The Effect of Chronic Progressive Nephropathy on the Incidence of Renal Tubule Cell Neoplasms in Control Male F344 Rats.

J. C. Seely, J. K. Haseman, A. Nyska, D. C. Wolf, J. I. Everitt, and J. R. Hailey (2002)
Toxicol Pathol 30, 681-686
 |  Abstract »  |  PDF »

Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility.

S. Yamashita, K. Wakazono, T. Sugimura, and T. Ushijima (2002)
Carcinogenesis 23, 923-928
 |  Abstract »  |  Full Text »  |  PDF »

Time- and Concentration-Dependent Increases in Cell Proliferation in Rats and Mice Administered Vinyl Acetate in Drinking Water.

R. Valentine, J. R. Bamberger, B. Szostek, S. R. Frame, J. F. Hansen, and M. S. Bogdanffy (2002)
Toxicol. Sci. 67, 190-197
 |  Abstract »  |  Full Text »  |  PDF »

Epigenetics and DNA Methylation Come of Age in Toxicology.

R. E. Watson and J. I. Goodman (2002)
Toxicol. Sci. 67, 11-16
 |  Abstract »  |  Full Text »  |  PDF »

Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.

Y. Yanaida, H. Kohno, K. Yoshida, Y. Hirose, Y. Yamada, H. Mori, and T. Tanaka (2002)
Carcinogenesis 23, 787-794
 |  Abstract »  |  Full Text »  |  PDF »

Lung tumors in A/J mice exposed to environmental tobacco smoke: estimated potency and implied human risk.

K. T. Bogen and H. Witschi (2002)
Carcinogenesis 23, 511-519
 |  Abstract »  |  Full Text »  |  PDF »

Breast Cancer Risk in Usual Ductal Hyperplasia Is Defined by Estrogen Receptor-{alpha} and Ki-67 Expression.

A. M. Shaaban, J. P. Sloane, C. R. West, and C. S. Foster (2002)
Am. J. Pathol. 160, 597-604
 |  Abstract »  |  Full Text »  |  PDF »

Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity.

G. M. Williams and M. J. Iatropoulos (2002)
Toxicol Pathol 30, 41-53
 |  Abstract »  |  PDF »

The null oncogene hypothesis and protection from cancer.

M P Davenport, R L Ward, and N J Hawkins (2002)
J. Med. Genet. 39, 12-14
 |  Abstract »  |  Full Text »  |  PDF »

Calorie Restriction Influences Cell Cycle Protein Expression and DNA Synthesis during Liver Regeneration.

A. G. Cuenca, W. D. Cress, R. A. Good, Y. Marikar, and R. W. Engelman (2001)
Experimental Biology and Medicine 226, 1061-1067
 |  Abstract »  |  Full Text »  |  PDF »

Dosimetry Modeling of Inhaled Formaldehyde: Comparisons of Local Flux Predictions in the Rat, Monkey, and Human Nasal Passages.

J. S. Kimbell, R. P. Subramaniam, E. A. Gross, P. M. Schlosser, and K. T. Morgan (2001)
Toxicol. Sci. 64, 100-110
 |  Abstract »  |  Full Text »  |  PDF »

Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay.

W. A. Deutsch, A. Kukreja, B. Shane, and V. Hegde (2001)
Mutagenesis 16, 439-442
 |  Abstract »  |  Full Text »  |  PDF »

Implications of Apoptosis for Toxicity, Carcinogenicity, and Risk Assessment: Fumonisin B1 as an Example.

Y. P. Dragan, W. R. Bidlack, S. M. Cohen, T. L. Goldsworthy, G. C. Hard, P. C. Howard, R. T. Riley, and K. A. Voss (2001)
Toxicol. Sci. 61, 6-17
 |  Abstract »  |  Full Text »  |  PDF »

Genetic and Nongenetic Factors Associated with Variation of Plasma Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor-binding Protein-3 in Healthy Premenopausal Women.

H. Jernström, C. Deal, F. Wilkin, W. Chu, Y. Tao, N. Majeed, T. Hudson, S. A. Narod, and M. Pollak (2001)
Cancer Epidemiol. Biomarkers Prev. 10, 377-384
 |  Abstract »  |  Full Text »

A Clonal Growth Model: Time-course Simulations of Liver Foci Growth following Penta- or Hexachlorobenzene Treatment in a Medium-term Bioassay.

Y. C. Ou, R. B. Conolly, R. S. Thomas, Y. Xu, M. E. Andersen, L. S. Chubb, H. C. Pitot, and R. S. H. Yang (2001)
Cancer Res. 61, 1879-1889
 |  Abstract »  |  Full Text »

Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.

M-W Yu, C-I Pai, S-Y Yang, T-J Hsiao, H-C Chang, S-M Lin, Y-F Liaw, P-J Chen, and C-J Chen (2000)
Gut 47, 703-709
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Rat Liver Foci Growth with a Quantitative Two-Cell Model after Treatment with 2,4,5,3',4'-Pentachlorobiphenyl.

M. Haag-Gronlund, R. Conolly, G. Scheu, L. Warngard, and R. Fransson-Steen (2000)
Toxicol. Sci. 57, 32-42
 |  Abstract »  |  Full Text »  |  PDF »

Toxicity of Tetrafluoroethylene and S-(1,1,2,2-tetrafluoroethyl)-L-cysteine in Rats and Mice.

D. A. Keller, G. L. Kennedy Jr., P. E. Ross, D. P. Kelly, and G. S. Elliott (2000)
Toxicol. Sci. 56, 414-423
 |  Abstract »  |  Full Text »  |  PDF »

Reevaluation of the Cancer Potency Factor of Toxaphene: Recommendations from a Peer Review Panel.

J. I. Goodman, D. J. Brusick, W. M. Busey, S. M. Cohen, J. C. Lamb, and T. B. Starr (2000)
Toxicol. Sci. 55, 3-16
 |  Abstract »  |  Full Text »  |  PDF »

Cell Death and Cell Proliferation in the Control of Normal and Neoplastic Tissue Growth.

J. R. Foster (2000)
Toxicol Pathol 28, 441-446
 |  Abstract »  |  PDF »

Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena.

H.S. Rosenkranz, N. Pollack, and A.R. Cunningham (2000)
Carcinogenesis 21, 1007-1011
 |  Abstract »  |  Full Text »  |  PDF »

Factors Underlying the Cell Growth-related Bystander Responses to {{alpha}} Particles.

R. Iyer and B. E. Lehnert (2000)
Cancer Res. 60, 1290-1298
 |  Abstract »  |  Full Text »

Cell Proliferation Induced by Triiodothyronine in Rat Liver Is Associated with Nodule Regression and Reduction of Hepatocellular Carcinomas.

G. M. Ledda-Columbano, A. Perra, R. Loi, H. Shinozuka, and A. Columbano (2000)
Cancer Res. 60, 603-609
 |  Abstract »  |  Full Text »

Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats.

K. Kawabata, T. Tanaka, T. Murakami, T. Okada, H. Murai, T. Yamamoto, A. Hara, M. Shimizu, Y. Yamada, K. Matsunaga, et al. (1999)
Carcinogenesis 20, 2109-2115
 |  Abstract »  |  Full Text »  |  PDF »

Reduced expression of the CDK inhibitor p27KIP1 in rat two-stage bladder carcinogenesis and its association with expression profiles of p21WAF1/Cip1 and p53.

C. C. R. Lee, T. Ichihara, S. Yamamoto, H. Wanibuchi, K. Sugimura, S. Wada, T. Kishimoto, and S. Fukushima (1999)
Carcinogenesis 20, 1697-1708
 |  Abstract »  |  Full Text »  |  PDF »

Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats.

M. Wei, H. Wanibuchi, S. Yamamoto, W. Li, and S. Fukushima (1999)
Carcinogenesis 20, 1873-1876
 |  Abstract »  |  Full Text »  |  PDF »

Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells.

B. Kroll, S. Kunz, T. Klein, and L. R. Schwarz (1999)
Carcinogenesis 20, 1411-1416
 |  Abstract »  |  Full Text »  |  PDF »

Modifying effects of a flavonoid morin on azoxymethane-induced large bowel tumorigenesis in rats.

T. Tanaka, K. Kawabata, M. Kakumoto, H. Makita, J. Ushida, S. Honjo, A. Hara, H. Tsuda, and H. Mori (1999)
Carcinogenesis 20, 1477-1484
 |  Abstract »  |  Full Text »  |  PDF »

Oxazepam is mutagenic in vivo in Big Blue(R) transgenic mice.

B.S. Shane, J.G. deBoer, B.W. Glickman, and M.L. Cunningham (1999)
Carcinogenesis 20, 1315-1321
 |  Abstract »  |  Full Text »  |  PDF »

Urothelium-specific Expression of an Oncogene in Transgenic Mice Induced the Formation of Carcinoma in Situ and Invasive Transitional Cell Carcinoma.

Z.-T. Zhang, J. Pak, E. Shapiro, T.-T. Sun, and X.-R. Wu (1999)
Cancer Res. 59, 3512-3517
 |  Abstract »  |  Full Text »  |  PDF »

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3.

J. Ma, M. N. Pollak, E. Giovannucci, J. M. Chan, Y. Tao, C. H. Hennekens, and M. J. Stampfer (1999)
J Natl Cancer Inst 91, 620-625
 |  Abstract »  |  Full Text »  |  PDF »

Commentary: Marriage of a Medium-Term Liver Model to Surrogate Markers--A Practical Approach for Risk and Benefit Assessment.

M. A. Moore, H. Tsuda, S. Tamano, A. Hagiwara, K. Imaida, T. Shirai, and N. Ito (1999)
Toxicol Pathol 27, 237-242
 |  Abstract »  |  PDF »

Induced expression of CYP2A5 in inflamed trematode-infested mouse liver.

R. Montero, G.J. Gentile, L. Frederick, J. McMannis, T. Murphy, G. Silva, H. Blankespoor, and J.M. Gentile (1999)
Mutagenesis 14, 217-220
 |  Abstract »  |  Full Text »  |  PDF »

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study.

J. M. Chan, M. J. Stampfer, E. Giovannucci, P. H. Gann, J. Ma, P. Wilkinson, C. H. Hennekens, and M. Pollak (1998)
Science 279, 563-566
 |  Abstract »  |  Full Text »

Urinary Bladder Carcinogenesis.

S. M. Cohen (1998)
Toxicol Pathol 26, 121-127
 |  Abstract »  |  PDF »

Review Article: A Brief Review of Formaldehyde Carcinogenesis in Relation to Rat Nasal Pathology and Human Health Risk Assessment.

K. T. Morgan (1997)
Toxicol Pathol 25, 291-305
 |  Abstract »  |  PDF »

Effects of Diet on Urinary Bladder Carcinogenesis and Cancer Prevention.

S. M. Cohen, T. Masui, E. M. Garland, and L. L. Arnold (1997)
J. Nutr. 127 , 826S
 |  Abstract »  |  Full Text »  |  PDF »

Review : Laboratory Studies in the Prediction of Lung Cancer Risk.

F. J. C. Roe (1996)
Indoor and Built Environment 5, 196-204
 |  Abstract »  |  PDF »

Letter to the Editor.

G. Schauer, H. Blode, and P. Gunzel (1996)
Human and Experimental Toxicology 15, 597-598
 |  PDF »

Irradiation Induces WAF1 Expression through a p53-independent Pathway in KG-1 Cells.

M. Akashi, M. Hachiya, Y. Osawa, K. Spirin, G. Suzuki, and H. P. Koeffler (1995)
J. Biol. Chem. 270, 19181-19187
 |  Abstract »  |  Full Text »  |  PDF »

Mismatch repair deficiency in phenotypically normal human cells.

R Parsons, G. Li, M Longley, P Modrich, B Liu, T Berk, Hamilton SR, K. Kinzler, and B Vogelstein (1995)
Science 268, 738-740
 |  Abstract »  |  PDF »

Relationship of DNA Adducts Derived from 2-Acetylaminofluorene to Cell Proliferation and the Induction of Rodent Liver and Bladder Tumors.

S. M. Cohen and L. B. Ellwein (1995)
Toxicol Pathol 23, 136-142
 |  Abstract »  |  PDF »

A Systemic Exposure-Based Alternative to the Maximum Tolerated Dose for Carcinogenicity Studies of Human Therapeutics.

J. F. Contrera, A. C. Jacobs, H. R. Prasanna, M. Mehta, W. J. Schmidt, and J. de George (1995)
International Journal of Toxicology 14, 1-10
 |  Abstract »  |  PDF »

Demonstration of a Temporal Relationship Between Ethyl Acrylate-Induced Forestomach Cell Proliferation and Carcinogenicity.

B. I. Ghanayem, I. M. Sanchez, H.B. Matthews, and M. R. Elwell (1994)
Toxicol Pathol 22, 497-509
 |  Abstract »  |  PDF »

Eugenol Triggers Different Pathobiological Effects on Human Oral Mucosal Fibroblasts 1.

J.H. Jeng, L.J. Hahn, E. Lu, Y. Wang, and M.Y.P. Kuo (1994)
Journal of Dental Research 73, 1050-1055
 |  Abstract »  |  PDF »

Organ or System Overload and Its Regulatory Implications.

R. Mermelstein, P. E. Morrow, and M. S. Christian (1994)
International Journal of Toxicology 13, 143-147
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Rodent Carcinogenicity Bioassay: Past, Present, and Future.

G. A. Boorman, R. R. Maronpot, and S. L. Eustis (1994)
Toxicol Pathol 22, 105-111
 |  Abstract »  |  PDF »

Current Knowledge of Mechanisms of Carcinogenicity: Genotoxins versus Non-genotoxins.

I.F.H. Purchase (1994)
Human and Experimental Toxicology 13, 17-28
 |  PDF »

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase.

L. Dumenco, E Allay, K Norton, and S. Gerson (1993)
Science 259, 219-222
 |  Abstract »  |  PDF »

Hepatocellular Proliferation in Ibuprofen-Treated Mice.

A. M. Bendele, J. F. Hulman, S. White, C. Brodhecker, and R. A. Bendele (1993)
Toxicol Pathol 21, 15-20
 |  Abstract »  |  PDF »

Review : Acetaldehyde and Formaldehyde: Is There a Cancer Risk for Man?.

F.J.C. Roe and D. Wood (1992)
Indoor and Built Environment 1, 8-15
 |  Abstract »  |  PDF »

A Retrospective Appraisal of the Ability of Animal Tests To Predict Reproductive and Developmental Toxicity in Humans.

T. A. Marks (1991)
International Journal of Toxicology 10, 569-584
 |  Abstract »  |  PDF »

Sustainability of Forestomach Hyperplasia in Rats Treated with Ethyl Acrylate for 13 Weeks and Regression after Cessation of Dosing.

B. I. Ghanayem, H. B. Matthews, and R. R. Maronpot (1991)
Toxicol Pathol 19, 273-279
 |  Abstract »  |  PDF »

Mitogenesis is only one factor in carcinogenesis.

I. Weinstein (1991)
Science 251, 387-388
 |  PDF »

Response.

B. N. AMES and L. S. GOLD (1991)
Science 251, 12-13
 |  PDF »

In Reply: Carcinogens and Human Health: Part 1.

B. N. Ames and L. S. Gold (1990)
Science 250, 1645-1646
 |  PDF »

Animal carcinogen testing challenged.

J Marx (1990)
Science 250, 743-745
 |  PDF »

RETHINKING CARCINOGENESIS AND THE TESTING OF POTENTIAL CARCINOGENS.

(1990)
Journal Watch (General) 1990, 6
 |  Full Text »

Too many rodent carcinogens: mitogenesis increases mutagenesis.

B. Ames and L. Gold (1990)
Science 249, 970-971
 |  PDF »

Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations.

W. Zhang, E. Remenyik, D. Zelterman, D. E. Brash, and N. M. Wikonkal (2001)
PNAS 98, 13948-13953
 |  Abstract »  |  Full Text »  |  PDF »

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