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Science 24 August 1990:
Vol. 249. no. 4971, pp. 924 - 926
DOI: 10.1126/science.2392684
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Articles

Science, Vol 249, Issue 4971, 924-926
Copyright © 1990 by American Association for the Advancement of Science

articles

Inhibition of leishmanias but not host macrophages by the antitubulin herbicide trifluralin

MM Chan and D Fong

Department of Biological Sciences, Rutgers, State University of New Jersey, Piscataway 08855.

The dinitroaniline herbicide trifluralin (alpha, alpha, alpha-trifluoro-2,6-dinitro-N, N-dipropyl-p-toluidine), at micromolar concentrations, selectively inhibited both proliferation and differentiation of the parasitic protozoan Leishmania mexicana amazonensis. In vitro, radioactive trifluralin showed specific binding to leishmania tubulin but not to mammalian tubulin. Because herbicides such as trifluralin are economical and are considered safe for man and domesticated animals, they may serve as useful sources of potential antiparasitic agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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C. Ma, C. Li, L. Ganesan, J. Oak, S. Tsai, D. Sept, and N. S. Morrissette (2007)
Mol. Biol. Cell 18, 4711-4720
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Dinitroanilines Bind {alpha}-Tubulin to Disrupt Microtubules.
N. S. Morrissette, A. Mitra, D. Sept, and L. D. Sibley (2004)
Mol. Biol. Cell 15, 1960-1968
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In Vitro and In Vivo Activities of a Triterpenoid Saponin Extract (PX-6518) from the Plant Maesa balansae against Visceral Leishmania Species.
L. Maes, D. V. Berghe, N. Germonprez, L. Quirijnen, P. Cos, N. De Kimpe, and L. Van Puyvelde (2004)
Antimicrob. Agents Chemother. 48, 130-136
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Selective Antimicrotubule Activity of N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against Kinetoplastid Parasites.
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Paclitaxel Arrests Growth of Intracellular Toxoplasma gondii.
R. Estes, N. Vogel, D. Mack, and R. McLeod (1998)
Antimicrob. Agents Chemother. 42, 2036-2040
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Synthesis and Evaluation of Dinitroanilines for Treatment of Cryptosporidiosis.
J. W. Benbow, E. L. Bernberg, A. Korda, and J. R. Mead (1998)
Antimicrob. Agents Chemother. 42, 339-343
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a-Tubulin Missense Mutations Correlate with Antimicrotubule Drug Resistance in Eleusine indica.
E. Yamamoto, L. Zeng, and W. V. Baird (1998)
PLANT CELL 10, 297-308
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)