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Science 17 August 1990:
Vol. 249. no. 4970, pp. 790 - 793
DOI: 10.1126/science.2167514
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Articles

Science, Vol 249, Issue 4970, 790-793
Copyright © 1990 by American Association for the Advancement of Science

articles

Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice

Y Ito, N Azrolan, A O'Connell, A Walsh, and JL Breslow

Rockefeller University, New York, NY 10021.

Primary and secondary hypertriglyceridemia is common in the general population, but the biochemical basis for this disease is largely unknown. With the use of transgenic technology, two lines of mice were created that express the human apolipoprotein CIII gene. One of these mouse lines with 100 copies of the gene was found to express large amounts of the protein and to be severely hypertriglyceridemic. The other mouse line with one to two copies of the gene expressed low amounts of the protein, but nevertheless manifested mild hypertriglyceridemia. Thus, overexpression of apolipoprotein CIII can be a primary cause of hypertriglyceridemia in vivo and may provide one possible etiology for this common disorder in humans.


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   Abstract »    Full Text »    PDF »
Distal Apolipoprotein C-III Regulatory Elements F to J Act as a General Modular Enhancer for Proximal Promoters That Contain Hormone Response Elements: Synergism Between Hepatic Nuclear Factor-4 Molecules Bound to the Proximal Promoter and Distal Enhancer Sites.
D. Kardassis, I. Tzameli, M. Hadzopoulou-Cladaras, I. Talianidis, and V. Zannis (1997)
Arterioscler Thromb Vasc Biol 17, 222-232
   Abstract »    Full Text »
Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects.
S. H. Hong, W. H. Park, C. C. Lee, J. H. Song, and J. Q Kim (1997)
Clin. Chem. 43, 13-17
   Abstract »    Full Text »    PDF »
Adenovirus-Mediated Gene Transfer as an In Vivo Probe of Lipoprotein Metabolism.
J. M. Leiden (1996)
Circulation 94, 2046-2051
   Full Text »
Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia.
A. P. Surguchov, G. P. Page, L. Smith, W. Patsch, and E. Boerwinkle (1996)
Arterioscler Thromb Vasc Biol 16, 941-947
   Abstract »    Full Text »
Transcriptional Regulation of the Genes Involved in Lipoprotein Transport : The Role of Proximal Promoters and Long-range Regulatory Elements and Factors in Apolipoprotein Gene Regulation.
D. Kardassis, M. Laccotripe, I. Talianidis, and V. Zannis (1996)
Hypertension 27, 980-1008
   Full Text »
Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.
R. H. J. B.-S. and Jacob Bar-Tana and R. Hertz (1995)
J. Biol. Chem. 270, 13470-13475
   Abstract »    Full Text »    PDF »
COOH-terminal Disruption of Lipoprotein Lipase in Mice Is Lethal in Homozygotes, but Heterozygotes Have Elevated Triglycerides and Impaired Enzyme Activity.
T. Coleman, R. L. Seip, J. M. Gimble, D. Lee, N. Maeda, and C. F. Semenkovich (1995)
J. Biol. Chem. 270, 12518-12525
   Abstract »    Full Text »    PDF »
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily..
F M Sladek, W M Zhong, E Lai, and J E Darnell (1990)
Genes & Dev. 4, 2353-2365
   Abstract »    PDF »
Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORalpha.
E. Raspe, H. Duez, P. Gervois, C. Fievet, J.-C. Fruchart, S. Besnard, J. Mariani, A. Tedgui, and B. Staels (2001)
J. Biol. Chem. 276, 2865-2871
   Abstract »    Full Text »    PDF »
A Hormone Response Element in the Human Apolipoprotein CIII (ApoCIII) Enhancer Is Essential for Intestinal Expression of the ApoA-I and ApoCIII Genes and Contributes to the Hepatic Expression of the Two Linked Genes in Transgenic Mice.
H.-Y. Kan, S. Georgopoulos, and V. Zannis (2000)
J. Biol. Chem. 275, 30423-30431
   Abstract »    Full Text »    PDF »
SMAD Proteins Transactivate the Human ApoCIII Promoter by Interacting Physically and Functionally with Hepatocyte Nuclear Factor 4.
D. Kardassis, K. Pardali, and V. I. Zannis (2000)
J. Biol. Chem. 275, 41405-41414
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-activated Receptor alpha Is Not Rate-limiting for the Lipoprotein-lowering Action of Fish Oil.
J. Dallongeville, E. Bauge, A. Tailleux, J. M. Peters, F. J. Gonzalez, J.-C. Fruchart, and B. Staels (2001)
J. Biol. Chem. 276, 4634-4639
   Abstract »    Full Text »    PDF »
Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11beta -Hydroxysteroid Dehydrogenase Type 1 Null Mice.
N. M. Morton, M. C. Holmes, C. Fievet, B. Staels, A. Tailleux, J. J. Mullins, and J. R. Seckl (2001)
J. Biol. Chem. 276, 41293-41300
   Abstract »    Full Text »    PDF »
Adenovirus-mediated Rescue of Lipoprotein Lipase-deficient Mice. LIPOLYSIS OF TRIGLYCERIDE-RICH LIPOPROTEINS IS ESSENTIAL FOR HIGH DENSITY LIPOPROTEIN MATURATION IN MICE.
J. G. Strauss, S. Frank, D. Kratky, G. Hammerle, A. Hrzenjak, G. Knipping, A. von Eckardstein, G. M. Kostner, and R. Zechner (2001)
J. Biol. Chem. 276, 36083-36090
   Abstract »    Full Text »    PDF »


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