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Science 10 August 1990:
Vol. 249. no. 4969, pp. 672 - 674
DOI: 10.1126/science.2382141
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Articles

Science, Vol 249, Issue 4969, 672-674
Copyright © 1990 by American Association for the Advancement of Science

articles

Predominant expression of T cell receptor V alpha 7 in tumor-infiltrating lymphocytes of uveal melanoma

T Nitta, Oksenberg JR, NA Rao, and L Steinman

Department of Genetics, Stanford University Medical Center, CA 94305.

Expression of T cell receptor (TCR) V alpha genes in tumor-infiltrating lymphocytes (TILs) within intraocular melanoma was studied. Primers for 18 different human TCR V alpha families were used to analyze TCR V alpha-C alpha gene rearrangements in TIL in these melanomas obtained at surgery. A limited number of TCR V alpha genes were expressed and rearranged in these tumors, and TILs expressing V alpha 7 were found in seven of eight of these uveal melanomas. TCR gene usage is also restricted in experimental autoimmune disease, in T cells within organs like skin and other epithelial tissues, and in the brain of patients with multiple sclerosis (MS). The restricted usage of TCR genes in TIL may indicate that a specific antigen in these melanomas is targeted.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Infect. Immun. 74, 4757-4765
   Abstract »    Full Text »    PDF »
Expression and Possible Function of IL-2 and IL-15 Receptors on Human Uveal Melanoma Cells.
Y.-G. He, E. Mayhew, J. Mellon, and J. Y. Niederkorn (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4240-4246
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Reduction of Liver Metastasis of Intraocular Melanoma by Interferon-{beta} Gene Transfer.
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Molecular Basis of T Cell-mediated Recognition of Pancreatic Cancer Cells.
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Construction and binding analysis of recombinant single-chain TCR derived from tumor-infiltrating lymphocytes and a cytotoxic T lymphocyte clone directed against MAGE-1.
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Idiopathic Dilated Cardiomyopathy : A Superantigen-Driven Autoimmune Disease.
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In vivo accumulation of the same anti-melanoma T cell clone in two different metastatic sites.
M. Hishii, D. Andrews, L. A. Boyle, J. T. Wong, F. Pandolfi, P. J. van den Elsen, and J. T. Kurnick (1997)
PNAS 94, 1378-1383
   Abstract »    Full Text »    PDF »
Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.
Z. Dembic, K. Schenck, and B. Bogen (2000)
PNAS 97, 2697-2702
   Abstract »    Full Text »    PDF »


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