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Science 10 August 1990:
Vol. 249. no. 4969, pp. 635 - 640
DOI: 10.1126/science.2116664

Articles

Science, Vol 249, Issue 4969, 635-640
Copyright © 1990 by American Association for the Advancement of Science


articles

The cellular functions of small GTP-binding proteins

A Hall

Chester Beatty Laboratories, Institute of Cancer Research, London, Great Britain.

A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.


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Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.
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Protein prenylation: a mediator of protein-protein interactions.
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Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils.
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A Gallo, E Benusiglio, I M Bonapace, A Feliciello, S Cassano, C Garbi, A M Musti, M E Gottesman, and E V Avvedimento (1992)
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Signal Transduction Mechanisms Involved in Salivary Gland Regulated Exocytosis.
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Molecular cloning of a member of a new class of low-molecular-weight GTP-binding proteins..
B H Morimoto, C C Chuang, and D E Koshland (1991)
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Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes.
M Benito, A Porras, A. Nebreda, and E Santos (1991)
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Diversity of G proteins in signal transduction.
M. Simon, M. Strathmann, and N Gautam (1991)
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   Abstract »    PDF »
Antiinflammatory and Antiarteriosclerotic Actions of HMG-CoA Reductase Inhibitors in a Rat Model of Chronic Inhibition of Nitric Oxide Synthesis.
W. Ni, K. Egashira, C. Kataoka, S. Kitamoto, M. Koyanagi, S. Inoue, and A. Takeshita (2001)
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   Abstract »    Full Text »    PDF »



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