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Science 27 July 1990:
Vol. 249. no. 4967, pp. 417 - 420
DOI: 10.1126/science.2165630
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Articles

Science, Vol 249, Issue 4967, 417-420
Copyright © 1990 by American Association for the Advancement of Science

articles

Functional organization of primate visual cortex revealed by high resolution optical imaging

DY Ts'o, RD Frostig, EE Lieke, and A Grinvald

Laboratory of Neurobiology, Rockefeller University, New York, NY 10021.

A high spatial resolution optical imaging system was developed to visualize cerebral cortical activity in vivo. This method is based on activity-dependent intrinsic signals and does not use voltage-sensitive dyes. Images of the living monkey striate (VI) and extrastriate (V2) visual cortex, taken during visual stimulation, were analyzed to yield maps of the distribution of cells with various functional properties. The cytochrome oxidase--rich blobs of V1 and the stripes of V2 were imaged in the living brain. In V2, no ocular dominance organization was seen, while regions of poor orientation tuning colocalized to every other cytochrome oxidase stripe. The orientation tuning of other regions of V2 appeared organized as modules that are larger and more uniform than those in V1.


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