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Science 27 July 1990:
Vol. 249. no. 4967, pp. 406 - 408
DOI: 10.1126/science.2377894
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Articles

Science, Vol 249, Issue 4967, 406-408
Copyright © 1990 by American Association for the Advancement of Science

articles

Polarity and velocity of sliding filaments: control of direction by actin and of speed by myosin

Sellers JR and B Kachar

Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Myosin filaments, which are responsible for a large repertoire of motile activities in muscle and nonmuscle cells, can translocate actin filaments both toward and away from their central bare zone. This bidirectional movement suggests that there is enough flexibility in the head portion of the tightly packed myosin molecules in the native myosin filaments to move actin filaments not only in the expected direction, but also in the direction opposite to that predicted by the regular structure of muscle--away from the center of the myosin filament.


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