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Science 27 July 1990: Vol. 249. no. 4967, pp. 374 - 379 DOI: 10.1126/science.1974085
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Articles
Science, Vol 249, Issue 4967, 374-379
Copyright © 1990 by American Association for the Advancement of Science
Murine developmental control genes
M Kessel
and
P Gruss
Max Planck-Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, FRG.
Various strategies have been used to isolate genes that participate in the regulation of mouse development. Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox (Hox), paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patterns. The functions of these genes can be analyzed molecularly in vitro and in vivo with the use of available mouse mutants or transgenic mice. In addition, it has been possible to generate gain- or loss-of-function mutations by random or targeted introduction of transgenes. Models derived from these studies can reveal the successive steps of developmental control on a genetic level.
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| Abstract »
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| Abstract »
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| Abstract »
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| Abstract »
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| PDF »
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| Abstract »
| PDF »
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- J Whiting, H Marshall, M Cook, R Krumlauf, P W Rigby, D Stott, and R K Allemann (1991)
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| Abstract »
| PDF »
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| Abstract »
| PDF »
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- J Rossant, R Zirngibl, D Cado, M Shago, and V Giguere (1991)
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| Abstract »
| PDF »
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| PDF »
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| Abstract »
| PDF »
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- M Hatano, C. Roberts, M Minden, W. Crist, and S. Korsmeyer (1991)
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| Abstract »
| PDF »
- Molecular basis of mouse developmental mutants..
- A D Reith and A Bernstein (1991)
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| PDF »
- Pattern formation during animal development.
- D. Melton (1991)
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| Abstract »
| PDF »
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- J D Allen, T Lints, N A Jenkins, N G Copeland, A Strasser, R P Harvey, and J M Adams (1991)
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| Abstract »
| PDF »
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- J Treisman, E Harris, and C Desplan (1991)
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| Abstract »
| PDF »
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- H Roelink and R Nusse (1991)
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| Abstract »
| PDF »
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- P J Mitchell, P M Timmons, J M Hebert, P W Rigby, and R Tjian (1991)
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| Abstract »
| PDF »
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- D. B. Edelman, R. Meech, and F. S. Jones (2000)
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| Abstract »
| Full Text »
| PDF »
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