Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 27 July 1990:
Vol. 249. no. 4967, pp. 374 - 379
DOI: 10.1126/science.1974085

Articles

Science, Vol 249, Issue 4967, 374-379
Copyright © 1990 by American Association for the Advancement of Science


articles

Murine developmental control genes

M Kessel and P Gruss

Max Planck-Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, FRG.

Various strategies have been used to isolate genes that participate in the regulation of mouse development. Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox (Hox), paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patterns. The functions of these genes can be analyzed molecularly in vitro and in vivo with the use of available mouse mutants or transgenic mice. In addition, it has been possible to generate gain- or loss-of-function mutations by random or targeted introduction of transgenes. Models derived from these studies can reveal the successive steps of developmental control on a genetic level.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube.
X. Miro, X. Zhou, S. Boretius, T. Michaelis, C. Kubisch, G. Alvarez-Bolado, and P. Gruss (2009)
Dis. Model. Mech. 2, 412-418
   Abstract »    Full Text »    PDF »
Generation of transgenic quail through germ cell-mediated germline transmission.
S. S. Shin, T. M. Kim, S. Y. Kim, T. W. Kim, H. W. Seo, S. K. Lee, S. C. Kwon, G. S. Lee, H. Kim, J. M. Lim, et al. (2008)
FASEB J 22, 2435-2444
   Abstract »    Full Text »    PDF »
Hox patterning of the vertebrate rib cage.
D. C. McIntyre, S. Rakshit, A. R. Yallowitz, L. Loken, L. Jeannotte, M. R. Capecchi, and D. M. Wellik (2007)
Development 134, 2981-2989
   Abstract »    Full Text »    PDF »
Neonatal Loss of Motor Function in Human Spina Bifida Aperta.
D. A. Sival, T. W. v. Weerden, J. S.H. Vles, A. Timmer, W. F.A. d. Dunnen, A.L. Staal-Schreinemachers, E. W. Hoving, K. M. Sollie, V. J.M. Kranen-Mastenbroek, P. J.J. Sauer, et al. (2004)
Pediatrics 114, 427-434
   Abstract »    Full Text »    PDF »
Congenital and Idiopathic Scoliosis: Clinical and Genetic Aspects.
P. F. Giampietro, R. D. Blank, C. L. Raggio, S. Merchant, F. S. Jacobsen, T. Faciszewski, S. K. Shukla, A. R. Greenlee, C. Reynolds, and D. B. Schowalter (2003)
Clin. Med. Res. 1, 125-136
   Abstract »    Full Text »    PDF »
Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands.
P. A. Shaw, X. Zhang, A. F. Russo, B. A. Amendt, S. Henderson, and V. Williams (2003)
J. Histochem. Cytochem. 51, 385-396
   Abstract »    Full Text »    PDF »
The Caudal homeodomain protein activates Drosophila E2F gene expression.
M.-S. Hwang, Y.-S. Kim, N.-H. Choi, J.-H. Park, E.-J. Oh, E.-J. Kwon, M. Yamaguchi, and M.-A. Yoo (2002)
Nucleic Acids Res. 30, 5029-5035
   Abstract »    Full Text »    PDF »
Overexpression of KNAT1 in Lettuce Shifts Leaf Determinate Growth to a Shoot-Like Indeterminate Growth Associated with an Accumulation of Isopentenyl-Type Cytokinins.
G. Frugis, D. Giannino, G. Mele, C. Nicolodi, A. Chiappetta, M. B. Bitonti, A. M. Innocenti, W. Dewitte, H. Van Onckelen, and D. Mariotti (2001)
Plant Physiology 126, 1370-1380
   Abstract »    Full Text »    PDF »
Hoxd10 induction and regionalization in the developing lumbosacral spinal cord.
C. Lance-Jones, N. Omelchenko, A. Bailis, S. Lynch, and K. Sharma (2001)
Development 128, 2255-2268
   Abstract »    Full Text »    PDF »
Hematopoietic Expression of Hoxb4 Is Regulated in Normal and Leukemic Stem Cells through Transcriptional Activation of the Hoxb4 Promoter by Upstream Stimulating Factor (Usf)-1 and Usf-2.
D. M. Giannola, W. D. Shlomchik, M. Jegathesan, D. Liebowitz, C. S. Abrams, T. Kadesch, A. Dancis, and S. G. Emerson (2000)
J. Exp. Med. 192, 1479-1490
   Abstract »    Full Text »    PDF »
The Caudal-related Homeodomain Protein Cdx1 Inhibits Proliferation of Intestinal Epithelial Cells by Down-regulation of D-type Cyclins.
J. Lynch, E.-R. Suh, D. G. Silberg, S. Rulyak, N. Blanchard, and P. G. Traber (2000)
J. Biol. Chem. 275, 4499-4506
   Abstract »    Full Text »    PDF »
Genetic and developmental bases of serial homology in vertebrate limb evolution.
I Ruvinsky and J. Gibson-Brown (2000)
Development 127, 5233-5244
   Abstract »    PDF »
Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation.
R Haraguchi, K Suzuki, R Murakami, M Sakai, M Kamikawa, M Kengaku, K Sekine, H Kawano, S Kato, N Ueno, et al. (2000)
Development 127, 2471-2479
   Abstract »    PDF »
Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium.
H. S. Taylor, P. Igarashi, D. L. Olive, and A. Arici (1999)
J. Clin. Endocrinol. Metab. 84, 1129-1135
   Abstract »    Full Text »
Are Homeobox Knotted-Like Genes and Cytokinins the Leaf Architects?.
G. Frugis, D. Giannino, G. Mele, C. Nicolodi, A. M. Innocenti, A. Chiappetta, M. Beatrice Bitonti, W. Dewitte, H. Van Onckelen, and D. Mariotti (1999)
Plant Physiology 119, 371-374
   Full Text »
Control of GL2 expression in Arabidopsis leaves and trichomes.
D. Szymanski, R. Jilk, S. Pollock, and M. Marks (1998)
Development 125, 1161-1171
   Abstract »    PDF »
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse..
S P Oh and E Li (1997)
Genes & Dev. 11, 1812-1826
   Abstract »    PDF »
Mammalian Homeobox B6 Expression Can Be Correlated With Erythropoietin Production Sites and Erythropoiesis During Development, But Not With Hematopoietic or Nonhematopoietic Stem Cell Populations.
F. Zimmermann and I. N. Rich (1997)
Blood 89, 2723-2735
   Abstract »    Full Text »    PDF »
Mice Bearing a Targeted Interruption of the Homeobox Gene HOXA9 Have Defects in Myeloid, Erythroid, and Lymphoid Hematopoiesis.
H. J. Lawrence, C. D. Helgason, G. Sauvageau, S. Fong, D. J. Izon, R. K. Humphries, and C. Largman (1997)
Blood 89, 1922-1930
   Abstract »    Full Text »    PDF »
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos.
K. Goh, J. Yang, and R. Hynes (1997)
Development 124, 4309-4319
   Abstract »    PDF »
Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.
I Duluc, O Lorentz, C Fritsch, C Leberquier, M Kedinger, and J. Freund (1997)
J. Cell Sci. 110, 1317-1324
   Abstract »    PDF »
Evidence in the mouse for self-renewing stem cells in the formation of a segmented longitudinal structure, the myotome.
J. Nicolas, L Mathis, C Bonnerot, and W Saurin (1996)
Development 122, 2933-2946
   Abstract »    PDF »
Analysis of Hox gene expression in the chick limb bud.
C. Nelson, B. Morgan, A. Burke, E Laufer, E DiMambro, L. Murtaugh, E Gonzales, L Tessarollo, L. Parada, and C Tabin (1996)
Development 122, 1449-1466
   Abstract »    PDF »
Sequence, Genomic Organization, and Expression of the Novel Homeobox Gene Hesx1.
P. Q. Thomas, B. V. Johnson, J. Rathjen, and P. D. Rathjen (1995)
J. Biol. Chem. 270, 3869-3875
   Abstract »    Full Text »    PDF »
Cloning and characterization of a second AP-2 transcription factor: AP-2 beta.
M Moser, A Imhof, A Pscherer, R Bauer, W Amselgruber, F Sinowatz, F Hofstadter, R Schule, and R Buettner (1995)
Development 121, 2779-2788
   Abstract »    PDF »
Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death.
G Yamada, A Mansouri, M Torres, E. Stuart, M Blum, M Schultz, E. De Robertis, and P Gruss (1995)
Development 121, 2917-2922
   Abstract »    PDF »
A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development.
T Knittel, M Kessel, M. Kim, and P Gruss (1995)
Development 121, 1077-1088
   Abstract »    PDF »
Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish.
M. Akimenko, S. Johnson, M Westerfield, and M Ekker (1995)
Development 121, 347-357
   Abstract »    PDF »
Nucleolar localisation of three Hox homeoproteins.
M. Corsetti, G Levi, F Lancia, L Sanseverino, S Ferrini, E Boncinelli, and G Corte (1995)
J. Cell Sci. 108, 187-193
   Abstract »    PDF »
Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing..
J A Epstein, T Glaser, J Cai, L Jepeal, D S Walton, and R L Maas (1994)
Genes & Dev. 8, 2022-2034
   Abstract »    PDF »
The spatial and temporal dynamics of Sax1 (CHox3) homeobox gene expression in the chick's spinal cord.
P Spann, M Ginsburg, Z Rangini, A Fainsod, H Eyal-Giladi, and Y Gruenbaum (1994)
Development 120, 1817-1828
   Abstract »    PDF »
A Chondroitin Sulfate Epitope in Mammalian Dental Pulp and its Developmental Expression in Mouse Dental Papilla.
P. Nieminen, S. Vainio, J. Jernvall, P.-L. Lukinmaa, E. Lehtonen, and I. Thesleff (1993)
Journal of Dental Research 72, 1460-1472
   Abstract »    PDF »
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm.
A. P. Monaghan, K. H. Kaestner, E. Grau, and G. Schutz (1993)
Development 119, 567-578
   Abstract »    PDF »
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.
B. G. Condie and M. R. Capecchi (1993)
Development 119, 579-595
   Abstract »    PDF »
The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.
I. Valarche, J. P. Tissier-Seta, M. R. Hirsch, S. Martinez, C. Goridis, and J. F. Brunet (1993)
Development 119, 881-896
   Abstract »    PDF »
Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation.
V Korzh, T Edlund, and S Thor (1993)
Development 118, 417-425
   Abstract »    PDF »
A Xenopus homebox gene defines dorsal-ventral domains in the developing brain.
M. Saha, R. Michel, K. Gulding, and R. Grainger (1993)
Development 118, 193-202
   Abstract »    PDF »
The mouse NCAM gene displays a biphasic expression pattern during neural tube development.
L Bally-Cuif, C Goridis, and M. Santoni (1993)
Development 117, 543-552
   Abstract »    PDF »
Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation.
M. Shenk, H. Bode, and R. Steele (1993)
Development 117, 657-667
   Abstract »    PDF »
Capacity to form choroid plexus-like cells in vitro is restricted to specific regions of the mouse neural ectoderm.
T. Thomas and M. Dziadek (1993)
Development 117, 253-262
   Abstract »    PDF »
Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system.
A. Zimmer and A. Zimmer (1992)
Development 116, 977-983
   Abstract »    PDF »
Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development.
D. E. Smith, F. Franco del Amo, and T. Gridley (1992)
Development 116, 1033-1039
   Abstract »    PDF »
Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos.
A. F. Candia, J. Hu, J. Crosby, P. A. Lalley, D. Noden, J. H. Nadeau, and C. V. Wright (1992)
Development 116, 1123-1136
   Abstract »    PDF »
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split..
Y Sasai, R Kageyama, Y Tagawa, R Shigemoto, and S Nakanishi (1992)
Genes & Dev. 6, 2620-2634
   Abstract »    PDF »
Peters' Anomaly and Associated Congenital Malformations.
E. I. Traboulsi and I. H. Maumenee (1992)
Arch Ophthalmol 110, 1739-1742
   Abstract »    PDF »
Selective disruption of genes expressed in totipotent embryonal stem cells..
H von Melchner, J V DeGregori, H Rayburn, S Reddy, C Friedel, and H E Ruley (1992)
Genes & Dev. 6, 919-927
   Abstract »    PDF »
Specific activation of mammalian Hox promoters in mosaic transgenic zebrafish..
M Westerfield, J Wegner, B G Jegalian, E M DeRobertis, and A W Puschel (1992)
Genes & Dev. 6, 591-598
   Abstract »    PDF »
A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain..
M L Dirksen and M Jamrich (1992)
Genes & Dev. 6, 599-608
   Abstract »    PDF »
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos..
M Taira, M Jamrich, P J Good, and I B Dawid (1992)
Genes & Dev. 6, 356-366
   Abstract »    PDF »
Homeobox genes go evolutionary.
J Marx (1992)
Science 255, 399-401
   PDF »
Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos.
D. Smith and T Gridley (1992)
Development 116, 555-561
   Abstract »    PDF »
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.
A Poleev, H Fickenscher, S Mundlos, A Winterpacht, B Zabel, A Fidler, P Gruss, and D Plachov (1992)
Development 116, 611-623
   Abstract »    PDF »
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
F. Del Amo, D. Smith, P. Swiatek, M Gendron-Maguire, R. Greenspan, A. McMahon, and T Gridley (1992)
Development 115, 737-744
   Abstract »    PDF »
Current Concepts in Embryonic Craniofacial Development.
G.H. Sperber (1992)
Critical Reviews in Oral Biology & Medicine 4, 67-72
   Full Text »    PDF »
Mediation and Inhibition of Cell Adhesion by Morphoregulatory Molecules.
G.M. Edelman (1992)
Cold Spring Harb Symp Quant Biol 57, 317-325
   Abstract »    PDF »
Of fin and fur: mutational analysis of vertebrate embryonic development..
J Rossant and N Hopkins (1992)
Genes & Dev. 6, 1-13
   PDF »
The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds..
B Robert, G Lyons, B K Simandl, A Kuroiwa, and M Buckingham (1991)
Genes & Dev. 5, 2363-2374
   Abstract »    PDF »
Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression..
J Whiting, H Marshall, M Cook, R Krumlauf, P W Rigby, D Stott, and R K Allemann (1991)
Genes & Dev. 5, 2048-2059
   Abstract »    PDF »
HOX-4 genes and the morphogenesis of mammalian genitalia..
P Dolle, J C Izpisua-Belmonte, J M Brown, C Tickle, and D Duboule (1991)
Genes & Dev. 5, 1767-1776
   Abstract »    PDF »
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis..
J Rossant, R Zirngibl, D Cado, M Shago, and V Giguere (1991)
Genes & Dev. 5, 1333-1344
   Abstract »    PDF »
Oct-3 and the beginning of mammalian development.
M. Rosner, M. Vigano, P. Rigby, H Arnheiter, and L. Staudt (1991)
Science 253, 144-145
   PDF »
Function of the homeodomain protein GHF1 in pituitary cell proliferation.
J. Castrillo, L. Theill, and M Karin (1991)
Science 253, 197-199
   Abstract »    PDF »
Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.
M Hatano, C. Roberts, M Minden, W. Crist, and S. Korsmeyer (1991)
Science 253, 79-82
   Abstract »    PDF »
Molecular basis of mouse developmental mutants..
A D Reith and A Bernstein (1991)
Genes & Dev. 5, 1115-1123
   PDF »
Pattern formation during animal development.
D. Melton (1991)
Science 252, 234-241
   Abstract »    PDF »
Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis..
J D Allen, T Lints, N A Jenkins, N G Copeland, A Strasser, R P Harvey, and J M Adams (1991)
Genes & Dev. 5, 509-520
   Abstract »    PDF »
The paired box encodes a second DNA-binding domain in the paired homeo domain protein..
J Treisman, E Harris, and C Desplan (1991)
Genes & Dev. 5, 594-604
   Abstract »    PDF »
Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube..
H Roelink and R Nusse (1991)
Genes & Dev. 5, 381-388
   Abstract »    PDF »
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis..
P J Mitchell, P M Timmons, J M Hebert, P W Rigby, and R Tjian (1991)
Genes & Dev. 5, 105-119
   Abstract »    PDF »
The Homeodomain Protein Barx2 Contains Activator and Repressor Domains and Interacts with Members of the CREB Family.
D. B. Edelman, R. Meech, and F. S. Jones (2000)
J. Biol. Chem. 275, 21737-21745
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)