Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 July 1990:
Vol. 249. no. 4966, pp. 298 - 301
DOI: 10.1126/science.2374929
Prev | Table of Contents | Next

Articles

Science, Vol 249, Issue 4966, 298-301
Copyright © 1990 by American Association for the Advancement of Science

articles

Angiotensin II-induced calcium mobilization in oocytes by signal transfer through gap junctions

K Sandberg, M Bor, H Ji, A Markwick, MA Millan, and KJ Catt

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

Angiotensin II (AII) stimulates rapid increases in the concentration of cytosolic calcium in follicular oocytes from Xenopus laevis. This calcium response was not present in denuded oocytes, indicating that it is mediated by AII receptors on the adherent follicular cells. The endogenous AII receptors differed in their binding properties from mammalian AII receptors expressed on the oocyte surface after injection of rat adrenal messenger RNA. Also, the calcium responses to activation of the amphibian AII receptor, but not the expressed mammalian AII receptor, were blocked reversibly by octanol and intracellular acidification, treatments that inhibit cell coupling through gap junctions. In addition, AII increased the rate of progesterone-induced maturation. Thus, an AII-induced calcium-mobilizing signal is transferred from follicle cells to the oocyte through gap junctions and may play a physiological role in oocyte maturation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
P. San-Cristobal, D. Pacheco-Alvarez, C. Richardson, A. M. Ring, N. Vazquez, F. H. Rafiqi, D. Chari, K. T. Kahle, Q. Leng, N. A. Bobadilla, et al. (2009)
PNAS 106, 4384-4389
   Abstract »    Full Text »    PDF »
Ionic Currents Activated via Purinergic Receptors in the Cumulus Cell-Enclosed Mouse Oocyte.
R. O. Arellano, A. Martinez-Torres, and E. Garay (2002)
Biol Reprod 67, 837-846
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XXIII. The Angiotensin II Receptors.
M. de Gasparo, K. J. Catt, T. Inagami, J. W. Wright, and Th. Unger (2000)
Pharmacol. Rev. 52, 415-472
   Abstract »    Full Text »    PDF »
Cl- currents activated via purinergic receptors in Xenopus follicles.
R. O. Arellano, E. Garay, and R. Miledi (1998)
Am J Physiol Cell Physiol 274, C333-C340
   Abstract »    Full Text »    PDF »
Averaging and globalising quotients of informetric and scientometric data.
L. Egghe and R. Rousseau (1996)
Journal of Information Science 22, 165-170
   Abstract »    PDF »
Intercellular propagation of calcium waves mediated by inositol trisphosphate.
S Boitano, E. Dirksen, and M. Sanderson (1992)
Science 258, 292-295
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)