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Science 20 July 1990:
Vol. 249. no. 4966, pp. 296 - 298
DOI: 10.1126/science.2374928
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Articles

Science, Vol 249, Issue 4966, 296-298
Copyright © 1990 by American Association for the Advancement of Science

articles

Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor

G Todderud, MI Wahl, SG Rhee, and G Carpenter

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.

Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.


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