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Science 20 July 1990:
Vol. 249. no. 4966, pp. 274 - 277
DOI: 10.1126/science.2142801
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Articles

Science, Vol 249, Issue 4966, 274-277
Copyright © 1990 by American Association for the Advancement of Science

articles

Transmembrane helical interactions and the assembly of the T cell receptor complex

N Manolios, JS Bonifacino, and RD Klausner

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

Studies of the subunit interactions of the multicomponent T cell antigen receptor (TCR) revealed that specific pairs of chains have the ability to assemble after transfection into fibroblasts. For one such pair, TCR-alpha and CD3-delta, their ability to assemble was encoded by their transmembrane domains. The specificity of this interaction suggests that well-defined helical interactions in the membrane can explain the assembly of some multichain membrane complexes.


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