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Science 29 June 1990:
Vol. 248. no. 4963, pp. 1653 - 1656
DOI: 10.1126/science.2163543
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Articles

Science, Vol 248, Issue 4963, 1653-1656
Copyright © 1990 by American Association for the Advancement of Science

articles

Intracellular calcium release mediated by sphingosine derivatives generated in cells

TK Ghosh, J Bian, and DL Gill

Department of Biological Chemistry, University of Maryland School of Medicine, Baltimore 21201.

Soluble and hydrophobic lipid breakdown products have a variety of important signaling roles in cells. Here sphingoid bases derived in cells from sphingolipid breakdown are shown to have a potent and direct effect in mediating calcium release from intracellular stores. Sphingosine must be enzymically converted within the cell to a product believed to be sphingosine-1-phosphate, which thereafter effects calcium release from a pool including the inositol 1,4,5-trisphosphate-sensitive calcium pool. The sensitivity, molecular specificity, and reversibility of the effect on calcium movements closely parallel sphingoid base-mediated inhibition of protein kinase C. Generation of sphingoid bases in cells may activate a dual signaling pathway involving regulation of calcium and protein kinase C, comparable perhaps to the phosphatidylinositol and calcium signaling pathway.


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Ca2+ Entry Mediated by Store Depletion, S-Nitrosylation, and TRP3 Channels. COMPARISON OF COUPLING AND FUNCTION.
D. B. van Rossum, R. L. Patterson, H.-T. Ma, and D. L. Gill (2000)
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Modification of Store-operated Channel Coupling and Inositol Trisphosphate Receptor Function by 2-Aminoethoxydiphenyl Borate in DT40 Lymphocytes.
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